SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q0Y_H_MOIH401_1 (FAB 9B1, HEAVY CHAIN FAB 9B1, LIGHT CHAIN)	5l08	CASPASE-8 (Homo sapiens)	4 / 7	GLU A 89 GLU A 64 ILE A 98 LEU A 75	None	1.47A	1q0yH-5l08A: undetectable 1q0yL-5l08A: undetectable	1q0yH-5l08A: 20.43 1q0yL-5l08A: 17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TW4_B_CHDB1130_0 (FATTY ACID-BINDING PROTEIN)	5l08	CASPASE-8 (Homo sapiens)	5 / 12	LEU A 160 LEU A 157 ILE A 142 ILE A 174 LEU A 171	None	1.25A	1tw4B-5l08A: undetectable	1tw4B-5l08A: 23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Y7I_A_SALA501_1 (SALICYLIC ACID-BINDING PROTEIN 2)	5l08	CASPASE-8 (Homo sapiens)	5 / 9	GLY A 11 ALA A 41 LEU A 14 PHE A 45 LEU A 22	None	1.28A	1y7iA-5l08A: undetectable	1y7iA-5l08A: 23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P7N_A_GCSA703_1 (POLY-BETA-1,6-N-ACET YL-D-GLUCOSAMINE N-DEACETYLASE)	5l08	CASPASE-8 (Homo sapiens)	4 / 4	LEU A 27 PHE A 24 LEU A 152 GLU A 147	None	1.45A	4p7nA-5l08A: undetectable	4p7nA-5l08A: 18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TVT_A_ASCA302_0 (THAUMATIN-1)	5l08	CASPASE-8 (Homo sapiens)	3 / 3	ARG A 162 GLN A 166 GLU A 126	None	0.93A	4tvtA-5l08A: undetectable	4tvtA-5l08A: 19.34

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Q0Y_H_MOIH401_1","FAB 9B1, HEAVY CHAIN;FAB 9B1, LIGHT CHAIN","5l08","CASPASE-8","Homo sapiens",4,"GLU A  89;GLU A  64;ILE A  98;LEU A  75","None","1.47A","1q0yH-5l08A:undetectable;1q0yL-5l08A:undetectable","1q0yH-5l08A:20.43;1q0yL-5l08A:17.67"],["1TW4_B_CHDB1130_0","FATTY ACID-BINDING PROTEIN","5l08","CASPASE-8","Homo sapiens",5,"LEU A 160;LEU A 157;ILE A 142;ILE A 174;LEU A 171","None","1.25A","1tw4B-5l08A:undetectable","1tw4B-5l08A:23.17"],["1Y7I_A_SALA501_1","SALICYLIC ACID-BINDING PROTEIN 2","5l08","CASPASE-8","Homo sapiens",5,"GLY A  11;ALA A  41;LEU A  14;PHE A  45;LEU A  22","None","1.28A","1y7iA-5l08A:undetectable","1y7iA-5l08A:23.53"],["4P7N_A_GCSA703_1","POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINE N-DEACETYLASE","5l08","CASPASE-8","Homo sapiens",4,"LEU A  27;PHE A  24;LEU A 152;GLU A 147","None","1.45A","4p7nA-5l08A:undetectable","4p7nA-5l08A:18.35"],["4TVT_A_ASCA302_0","THAUMATIN-1","5l08","CASPASE-8","Homo sapiens",3,"ARG A 162;GLN A 166;GLU A 126","None","0.93A","4tvtA-5l08A:undetectable","4tvtA-5l08A:19.34"]]