SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l09'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR
(Yersinia
enterocolitica) 		5 / 12 TYR A 110
THR A 111
TYR A  50
SER A  32
VAL A  69
 None
None
482  A 201 (-4.5A)
482  A 201 (-2.8A)
482  A 201 (-4.6A)
 1.26A 1z9hA-5l09A:
undetectable		 1z9hA-5l09A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR
(Yersinia
enterocolitica) 		5 / 12 TYR A 110
THR A 111
TYR A  50
SER A  32
VAL A  69
 None
None
482  A 201 (-4.5A)
482  A 201 (-2.8A)
482  A 201 (-4.6A)
 1.27A 1z9hB-5l09A:
undetectable		 1z9hB-5l09A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR
(Yersinia
enterocolitica) 		5 / 12 TYR A 110
THR A 111
TYR A  50
SER A  32
VAL A  69
 None
None
482  A 201 (-4.5A)
482  A 201 (-2.8A)
482  A 201 (-4.6A)
 1.26A 1z9hC-5l09A:
undetectable		 1z9hC-5l09A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_1
(HYPOTHETICAL PROTEIN)		 5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR
(Yersinia
enterocolitica) 		4 / 4 GLU A   9
ASP A   7
ASP A  14
TYR A 162
 None
 1.44A 2yvlA-5l09A:
undetectable		 2yvlA-5l09A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR
(Yersinia
enterocolitica) 		5 / 12 ASN A 125
VAL A  69
TYR A  63
PHE A  98
TYR A  50
 482  A 201 (-3.7A)
482  A 201 (-4.6A)
None
482  A 201 (-3.5A)
482  A 201 (-4.5A)
 1.50A 3megA-5l09A:
undetectable		 3megA-5l09A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR
(Yersinia
enterocolitica) 		5 / 12 TYR A  50
LEU A  29
SER A 139
PHE A 112
LEU A 124
 482  A 201 (-4.5A)
None
None
None
None
 1.41A 3vw1B-5l09A:
undetectable		 3vw1B-5l09A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR
(Yersinia
enterocolitica) 		4 / 7 GLY A  27
PHE A 136
ARG A  22
ASP A  28
 None
None
EDO  A 203 (-3.9A)
None
 1.11A 5n5dB-5l09A:
undetectable		 5n5dB-5l09A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR
(Yersinia
enterocolitica) 		4 / 5 GLY A 129
ASN A 128
ASP A 131
ARG A  30
 SO4  A 202 (-3.6A)
None
SO4  A 202 ( 4.3A)
ACY  A 206 ( 3.1A)
 1.30A 6dwdB-5l09A:
undetectable
6dwdD-5l09A:
undetectable		 6dwdB-5l09A:
16.27
6dwdD-5l09A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR
(Yersinia
enterocolitica) 		4 / 6 VAL A  35
LEU A 151
LEU A 114
HIS A 115
 None
 0.96A 6e43D-5l09A:
undetectable		 6e43D-5l09A:
17.63