SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l0l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5l0l UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 PHE A 249
ALA A 264
ARG A 143
ASP A 250
 None
 1.21A 2e5dA-5l0lA:
undetectable
2e5dB-5l0lA:
undetectable		 2e5dA-5l0lA:
18.89
2e5dB-5l0lA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5l0l UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 ASP A 250
PHE A 249
ALA A 264
ARG A 143
 None
 1.17A 2e5dA-5l0lA:
undetectable
2e5dB-5l0lA:
undetectable		 2e5dA-5l0lA:
18.89
2e5dB-5l0lA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 5l0l UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 ARG A 227
GLN A 262
PRO A 243
 None
 0.96A 2qhfA-5l0lA:
undetectable		 2qhfA-5l0lA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 5l0l UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 GLU A 295
PHE A 296
GLN A 181
 None
 0.80A 3r55A-5l0lA:
0.6		 3r55A-5l0lA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5l0l UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 8 TYR A 130
VAL A 132
MET A 224
ILE A 144
 None
 0.70A 4a97C-5l0lA:
undetectable		 4a97C-5l0lA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5l0l UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 8 TYR A 130
VAL A 132
MET A 224
ILE A 144
 None
 0.82A 4a97D-5l0lA:
undetectable		 4a97D-5l0lA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5l0l UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 8 TYR A 130
VAL A 132
MET A 224
ILE A 144
 None
 0.77A 4a97G-5l0lA:
undetectable		 4a97G-5l0lA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5l0l UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 8 TYR A 130
VAL A 132
MET A 224
ILE A 144
 None
 0.77A 4a97I-5l0lA:
undetectable		 4a97I-5l0lA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5l0l UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 5 HIS A 129
TYR A 128
TYR A 130
GLU A 168
 None
 1.49A 4ae1B-5l0lA:
undetectable		 4ae1B-5l0lA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 5l0l UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 PHE A 279
ALA A 277
MET A 278
GLY A 237
LEU A 240
 None
 1.19A 4kykA-5l0lA:
undetectable
4kykB-5l0lA:
undetectable		 4kykA-5l0lA:
21.52
4kykB-5l0lA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5l0l UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 11 GLY A 187
GLY A 228
LEU A 188
GLN A 191
TRP A 225
 None
 1.12A 4l8fB-5l0lA:
undetectable		 4l8fB-5l0lA:
21.38