SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 5l0p TRANSCRIPTION FACTOR
ETV6, TRANSCRIPTION
FACTOR ETV6,
TRANSCRIPTION FACTOR
ETV6, FERRIC UPTAKE
REGULATION PROTEIN
CHIMERA
(Homo
sapiens;
Klebsiella
pneumoniae) 		3 / 3 ASP A  65
LEU A  60
LEU A  61
 None
 0.74A 1np1B-5l0pA:
undetectable		 1np1B-5l0pA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 5l0p TRANSCRIPTION FACTOR
ETV6, TRANSCRIPTION
FACTOR ETV6,
TRANSCRIPTION FACTOR
ETV6, FERRIC UPTAKE
REGULATION PROTEIN
CHIMERA
(Homo
sapiens;
Klebsiella
pneumoniae) 		3 / 3 ASP A 236
LEU A 231
LEU A 232
 None
 0.74A 1np1B-5l0pA:
undetectable		 1np1B-5l0pA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5l0p TRANSCRIPTION FACTOR
ETV6, TRANSCRIPTION
FACTOR ETV6,
TRANSCRIPTION FACTOR
ETV6, FERRIC UPTAKE
REGULATION PROTEIN
CHIMERA
(Homo
sapiens;
Klebsiella
pneumoniae) 		5 / 10 THR A 284
ILE A 290
LEU A 294
VAL A 336
ARG A 287
 None
 1.03A 2wd9C-5l0pA:
undetectable		 2wd9C-5l0pA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5l0p TRANSCRIPTION FACTOR
ETV6, TRANSCRIPTION
FACTOR ETV6,
TRANSCRIPTION FACTOR
ETV6, FERRIC UPTAKE
REGULATION PROTEIN
CHIMERA
(Homo
sapiens;
Klebsiella
pneumoniae) 		5 / 10 THR A 284
ILE A 290
VAL A 336
GLN A 329
ARG A 287
 None
 1.09A 2wd9C-5l0pA:
undetectable		 2wd9C-5l0pA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5l0p TRANSCRIPTION FACTOR
ETV6, TRANSCRIPTION
FACTOR ETV6,
TRANSCRIPTION FACTOR
ETV6, FERRIC UPTAKE
REGULATION PROTEIN
CHIMERA
(Klebsiella
pneumoniae;
Homo
sapiens) 		5 / 12 TRP A 119
PHE A 137
GLY A 141
ILE A 109
LEU A 145
 None
 1.11A 3iv6A-5l0pA:
undetectable		 3iv6A-5l0pA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 5l0p TRANSCRIPTION FACTOR
ETV6, TRANSCRIPTION
FACTOR ETV6,
TRANSCRIPTION FACTOR
ETV6, FERRIC UPTAKE
REGULATION PROTEIN
CHIMERA
(Klebsiella
pneumoniae;
Homo
sapiens) 		4 / 5 GLY A 344
LYS A 345
GLU A 305
GLY A 343
 None
 1.00A 3onnA-5l0pA:
undetectable		 3onnA-5l0pA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 5l0p TRANSCRIPTION FACTOR
ETV6, TRANSCRIPTION
FACTOR ETV6,
TRANSCRIPTION FACTOR
ETV6, FERRIC UPTAKE
REGULATION PROTEIN
CHIMERA
(Klebsiella
pneumoniae;
Homo
sapiens) 		3 / 3 ASP A  75
TRP A  36
SER A  70
 None
 1.06A 4lrhA-5l0pA:
undetectable		 4lrhA-5l0pA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5l0p TRANSCRIPTION FACTOR
ETV6, TRANSCRIPTION
FACTOR ETV6,
TRANSCRIPTION FACTOR
ETV6, FERRIC UPTAKE
REGULATION PROTEIN
CHIMERA
(Klebsiella
pneumoniae;
Homo
sapiens) 		4 / 4 ASP A  28
SER A  26
ASP A  29
HIS A  17
 None
 1.41A 5wyqB-5l0pA:
undetectable		 5wyqB-5l0pA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5l0p TRANSCRIPTION FACTOR
ETV6, TRANSCRIPTION
FACTOR ETV6,
TRANSCRIPTION FACTOR
ETV6, FERRIC UPTAKE
REGULATION PROTEIN
CHIMERA
(Klebsiella
pneumoniae;
Homo
sapiens) 		4 / 6 LYS A 121
GLN A 118
LEU A 166
PHE A 127
 None
 1.26A 6nmpC-5l0pA:
undetectable
6nmpJ-5l0pA:
undetectable		 6nmpC-5l0pA:
20.11
6nmpJ-5l0pA:
11.19