SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l0w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 5l0w SEC71
SEC72
(Chaetomium
thermophilum) 		4 / 8 GLN A  32
LEU B  44
LEU B  12
LEU B  28
 None
 1.16A 1hk2A-5l0wA:
undetectable		 1hk2A-5l0wA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5l0w SEC71
SEC72
(Chaetomium
thermophilum) 		5 / 12 VAL A 115
LEU A  64
LEU A  63
LEU A  39
GLU B  40
 None
 1.26A 1mmkA-5l0wA:
undetectable		 1mmkA-5l0wA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5l0w SEC72
(Chaetomium
thermophilum) 		5 / 12 GLY B  93
ALA B 132
ASP B  94
ALA B  95
TYR B  99
 None
 1.40A 2avdB-5l0wB:
undetectable		 2avdB-5l0wB:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5l0w SEC71
SEC72
(Chaetomium
thermophilum) 		5 / 11 SER A  57
TRP A 126
ILE A  59
ALA A  62
LEU B  44
 None
 1.15A 3n8yA-5l0wA:
undetectable		 3n8yA-5l0wA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5l0w SEC71
(Chaetomium
thermophilum) 		5 / 12 LEU A  63
ALA A  62
LEU A  39
LEU A  40
HIS A  30
 None
 1.31A 3olsB-5l0wA:
undetectable		 3olsB-5l0wA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5l0w SEC71
SEC72
(Chaetomium
thermophilum) 		5 / 12 ILE B  55
ALA B 111
LEU B  47
LEU A  64
ILE A 137
 None
 0.97A 3uvvA-5l0wB:
undetectable		 3uvvA-5l0wB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5l0w SEC71
SEC72
(Chaetomium
thermophilum) 		5 / 9 ALA A 134
ASN A 120
VAL A 123
GLY A 127
VAL B  61
 None
 1.18A 4r20B-5l0wA:
undetectable		 4r20B-5l0wA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5l0w SEC72
(Chaetomium
thermophilum) 		5 / 12 GLY B  93
ALA B 132
ASP B  94
ALA B  95
TYR B  99
 None
 1.37A 4ymgB-5l0wB:
undetectable		 4ymgB-5l0wB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5l0w SEC71
(Chaetomium
thermophilum) 		4 / 6 TYR A  36
ILE A  59
ALA A 121
MET A 117
 None
 1.03A 6hu9m-5l0wA:
undetectable
6hu9q-5l0wA:
undetectable		 6hu9m-5l0wA:
15.36
6hu9q-5l0wA:
23.28