SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l0z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		5 / 12 ILE A 255
ALA A 269
LEU A 266
LEU A 139
ALA A 155
 SAM  A 304 (-3.9A)
SAM  A 304 (-3.6A)
SO4  A 303 (-4.4A)
None
None
 1.24A 1g5yB-5l0zA:
undetectable		 1g5yB-5l0zA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		4 / 8 GLU A 168
GLY A 167
ASP A  42
ASP A 171
 None
 0.88A 1m4iA-5l0zA:
undetectable		 1m4iA-5l0zA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		7 / 12 LEU A 214
GLY A 235
GLY A 240
ILE A 255
SER A 263
LEU A 264
ALA A 269
 SAM  A 304 (-4.3A)
SAM  A 304 (-3.2A)
SAM  A 304 (-3.4A)
SAM  A 304 (-3.9A)
SAM  A 304 (-3.1A)
SAM  A 304 (-3.8A)
SAM  A 304 (-3.6A)
 0.53A 1v2xA-5l0zA:
19.2		 1v2xA-5l0zA:
23.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		7 / 11 THR A 212
GLY A 235
GLY A 240
ILE A 255
SER A 263
LEU A 264
ALA A 269
 SAM  A 304 (-3.7A)
SAM  A 304 (-3.2A)
SAM  A 304 (-3.4A)
SAM  A 304 (-3.9A)
SAM  A 304 (-3.1A)
SAM  A 304 (-3.8A)
SAM  A 304 (-3.6A)
 0.65A 1x7pA-5l0zA:
29.3
1x7pB-5l0zA:
29.5		 1x7pA-5l0zA:
32.67
1x7pB-5l0zA:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		6 / 10 THR A 212
GLY A 235
GLY A 240
ILE A 255
LEU A 264
ALA A 269
 SAM  A 304 (-3.7A)
SAM  A 304 (-3.2A)
SAM  A 304 (-3.4A)
SAM  A 304 (-3.9A)
SAM  A 304 (-3.8A)
SAM  A 304 (-3.6A)
 0.38A 1x7pA-5l0zA:
29.3
1x7pB-5l0zA:
29.5		 1x7pA-5l0zA:
32.67
1x7pB-5l0zA:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		5 / 11 VAL A 142
ILE A 151
GLY A 149
ILE A 190
LEU A 165
 None
 1.07A 1z11B-5l0zA:
undetectable		 1z11B-5l0zA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		5 / 9 THR A 170
PHE A 173
VAL A 142
GLY A 149
ILE A 151
 None
 1.48A 2w98A-5l0zA:
2.4		 2w98A-5l0zA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		6 / 10 LEU A 139
ALA A 267
LEU A 274
VAL A 137
SER A 184
ILE A 188
 None
 1.44A 2w9hA-5l0zA:
undetectable		 2w9hA-5l0zA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		5 / 12 LEU A 165
ALA A 155
THR A 177
ILE A 190
THR A 181
 None
 1.07A 3c6gA-5l0zA:
undetectable		 3c6gA-5l0zA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		5 / 12 LEU A 165
ALA A 155
THR A 177
ILE A 190
THR A 181
 None
 1.13A 3czhB-5l0zA:
undetectable		 3czhB-5l0zA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		6 / 11 THR A 212
GLY A 235
GLY A 240
ILE A 255
LEU A 264
ALA A 269
 SAM  A 304 (-3.7A)
SAM  A 304 (-3.2A)
SAM  A 304 (-3.4A)
SAM  A 304 (-3.9A)
SAM  A 304 (-3.8A)
SAM  A 304 (-3.6A)
 0.47A 3dcmX-5l0zA:
13.8		 3dcmX-5l0zA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		5 / 9 ARG A 278
ALA A 138
VAL A 209
ILE A 128
PRO A 229
 None
 1.04A 3el4B-5l0zA:
undetectable		 3el4B-5l0zA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		4 / 8 ILE A  56
ALA A  84
THR A  87
VAL A 114
 None
 0.80A 3me6B-5l0zA:
undetectable		 3me6B-5l0zA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		6 / 12 ASN A 147
GLY A 235
GLY A 240
ILE A 255
SER A 263
ASN A 265
 SO4  A 303 (-3.8A)
SAM  A 304 (-3.2A)
SAM  A 304 (-3.4A)
SAM  A 304 (-3.9A)
SAM  A 304 (-3.1A)
SO4  A 303 (-3.9A)
 0.60A 3nk7A-5l0zA:
23.9		 3nk7A-5l0zA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		6 / 12 GLY A 235
GLU A 237
GLY A 240
ILE A 255
SER A 263
ASN A 265
 SAM  A 304 (-3.2A)
SO4  A 303 ( 4.8A)
SAM  A 304 (-3.4A)
SAM  A 304 (-3.9A)
SAM  A 304 (-3.1A)
SO4  A 303 (-3.9A)
 1.22A 3nk7A-5l0zA:
23.9		 3nk7A-5l0zA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		6 / 12 ASN A 147
GLY A 235
GLY A 240
ILE A 255
SER A 263
LEU A 264
 SO4  A 303 (-3.8A)
SAM  A 304 (-3.2A)
SAM  A 304 (-3.4A)
SAM  A 304 (-3.9A)
SAM  A 304 (-3.1A)
SAM  A 304 (-3.8A)
 0.65A 3nk7B-5l0zA:
24.7		 3nk7B-5l0zA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		6 / 12 GLY A 235
GLU A 237
GLY A 240
ILE A 255
SER A 263
LEU A 264
 SAM  A 304 (-3.2A)
SO4  A 303 ( 4.8A)
SAM  A 304 (-3.4A)
SAM  A 304 (-3.9A)
SAM  A 304 (-3.1A)
SAM  A 304 (-3.8A)
 0.97A 3nk7B-5l0zA:
24.7		 3nk7B-5l0zA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		4 / 7 MET A 273
ARG A 254
VAL A 210
GLU A 276
 None
 1.11A 4jseA-5l0zA:
undetectable
4jseB-5l0zA:
undetectable		 4jseA-5l0zA:
21.70
4jseB-5l0zA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		4 / 7 GLU A 276
MET A 273
ARG A 254
VAL A 210
 None
 1.19A 4jseA-5l0zA:
undetectable
4jseB-5l0zA:
undetectable		 4jseA-5l0zA:
21.70
4jseB-5l0zA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		4 / 7 VAL A  97
ILE A 105
ARG A  33
ILE A  32
 None
 0.92A 4lv9B-5l0zA:
undetectable		 4lv9B-5l0zA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		3 / 3 ASP A  31
HIS A  40
LYS A  30
 CO  A 301 ( 4.6A)
CO  A 301 (-3.1A)
None
 0.93A 4qzuD-5l0zA:
undetectable		 4qzuD-5l0zA:
17.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		12 / 12 THR A 212
LEU A 214
GLY A 235
GLY A 240
ARG A 254
ILE A 255
GLN A 257
ASP A 262
SER A 263
LEU A 264
LEU A 266
ALA A 269
 SAM  A 304 (-3.7A)
SAM  A 304 (-4.3A)
SAM  A 304 (-3.2A)
SAM  A 304 (-3.4A)
None
SAM  A 304 (-3.9A)
SAM  A 304 (-4.0A)
SAM  A 304 (-3.0A)
SAM  A 304 (-3.1A)
SAM  A 304 (-3.8A)
SO4  A 303 (-4.4A)
SAM  A 304 (-3.6A)
 0.00A 5l0zA-5l0zA:
44.4		 5l0zA-5l0zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		9 / 10 THR A 212
GLY A 235
GLY A 240
ILE A 255
GLN A 257
SER A 263
LEU A 264
LEU A 266
ALA A 269
 SAM  A 304 (-3.7A)
SAM  A 304 (-3.2A)
SAM  A 304 (-3.4A)
SAM  A 304 (-3.9A)
SAM  A 304 (-4.0A)
SAM  A 304 (-3.1A)
SAM  A 304 (-3.8A)
SO4  A 303 (-4.4A)
SAM  A 304 (-3.6A)
 0.47A 5l0zB-5l0zA:
39.2		 5l0zB-5l0zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		8 / 10 THR A 212
LEU A 214
GLY A 235
GLY A 240
ILE A 255
GLN A 257
LEU A 266
ALA A 269
 SAM  A 304 (-3.7A)
SAM  A 304 (-4.3A)
SAM  A 304 (-3.2A)
SAM  A 304 (-3.4A)
SAM  A 304 (-3.9A)
SAM  A 304 (-4.0A)
SO4  A 303 (-4.4A)
SAM  A 304 (-3.6A)
 0.80A 5l0zB-5l0zA:
39.2		 5l0zB-5l0zA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY
(Sinorhizobium
meliloti) 		5 / 10 HIS A 213
GLY A 235
GLY A 240
LEU A 264
ALA A 269
 None
SAM  A 304 (-3.2A)
SAM  A 304 (-3.4A)
SAM  A 304 (-3.8A)
SAM  A 304 (-3.6A)
 0.57A 5o96C-5l0zA:
13.8
5o96D-5l0zA:
14.0		 5o96C-5l0zA:
22.48
5o96D-5l0zA:
22.48