SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LWE_A_NVPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	5l10	N-ACYLHOMOSERINE LACTONE DEPENDENT REGULATORY PROTEIN (Burkholderia cenocepacia)	4 / 7	VAL A 39 TYR A 40 GLY A 57 TYR A 67	None None None GOL A 201 ( 4.9A)	0.96A	1lweA-5l10A: undetectable	1lweA-5l10A: 14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6D_A_SAMA1350_0 (HYDROXYINDOLE O-METHYLTRANSFERASE)	5l10	N-ACYLHOMOSERINE LACTONE DEPENDENT REGULATORY PROTEIN (Burkholderia cenocepacia)	5 / 12	GLY A 127 GLY A 118 ILE A 79 VAL A 82 ALA A 157	None	1.11A	4a6dA-5l10A: undetectable	4a6dA-5l10A: 20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6E_A_SAMA1349_0 (HYDROXYINDOLE O-METHYLTRANSFERASE)	5l10	N-ACYLHOMOSERINE LACTONE DEPENDENT REGULATORY PROTEIN (Burkholderia cenocepacia)	5 / 12	GLY A 127 GLY A 118 ILE A 79 VAL A 82 ALA A 157	None	1.17A	4a6eA-5l10A: undetectable	4a6eA-5l10A: 20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P6X_E_HCYE900_1 (GLUCOCORTICOID RECEPTOR)	5l10	N-ACYLHOMOSERINE LACTONE DEPENDENT REGULATORY PROTEIN (Burkholderia cenocepacia)	5 / 12	LEU A 129 GLY A 119 MET A 162 LEU A 161 ILE A 78	None FMT A 202 (-3.4A) None None GOL A 201 ( 4.1A)	1.36A	4p6xE-5l10A: undetectable	4p6xE-5l10A: 18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NFP_A_8W5A804_2 (GLUCOCORTICOID RECEPTOR)	5l10	N-ACYLHOMOSERINE LACTONE DEPENDENT REGULATORY PROTEIN (Burkholderia cenocepacia)	4 / 4	LEU A 129 MET A 162 ILE A 78 LEU A 126	None None GOL A 201 ( 4.1A) None	1.26A	5nfpA-5l10A: undetectable	5nfpA-5l10A: 18.21

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1LWE_A_NVPA999_1","HIV-1 REVERSE TRANSCRIPTASE","5l10","N-ACYLHOMOSERINE LACTONE DEPENDENT REGULATORY PROTEIN","Burkholderia cenocepacia",4,"VAL A  39;TYR A  40;GLY A  57;TYR A  67","None;None;None;GOL A 201 ( 4.9A)","0.96A","1lweA-5l10A:undetectable","1lweA-5l10A:14.31"],["4A6D_A_SAMA1350_0","HYDROXYINDOLE O-METHYLTRANSFERASE","5l10","N-ACYLHOMOSERINE LACTONE DEPENDENT REGULATORY PROTEIN","Burkholderia cenocepacia",5,"GLY A 127;GLY A 118;ILE A  79;VAL A  82;ALA A 157","None","1.11A","4a6dA-5l10A:undetectable","4a6dA-5l10A:20.17"],["4A6E_A_SAMA1349_0","HYDROXYINDOLE O-METHYLTRANSFERASE","5l10","N-ACYLHOMOSERINE LACTONE DEPENDENT REGULATORY PROTEIN","Burkholderia cenocepacia",5,"GLY A 127;GLY A 118;ILE A  79;VAL A  82;ALA A 157","None","1.17A","4a6eA-5l10A:undetectable","4a6eA-5l10A:20.17"],["4P6X_E_HCYE900_1","GLUCOCORTICOID RECEPTOR","5l10","N-ACYLHOMOSERINE LACTONE DEPENDENT REGULATORY PROTEIN","Burkholderia cenocepacia",5,"LEU A 129;GLY A 119;MET A 162;LEU A 161;ILE A  78","None;FMT A 202 (-3.4A);None;None;GOL A 201 ( 4.1A)","1.36A","4p6xE-5l10A:undetectable","4p6xE-5l10A:18.70"],["5NFP_A_8W5A804_2","GLUCOCORTICOID RECEPTOR","5l10","N-ACYLHOMOSERINE LACTONE DEPENDENT REGULATORY PROTEIN","Burkholderia cenocepacia",4,"LEU A 129;MET A 162;ILE A  78;LEU A 126","None;None;GOL A 201 ( 4.1A);None","1.26A","5nfpA-5l10A:undetectable","5nfpA-5l10A:18.21"]]