SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l16'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE
(Leishmania
major) 		5 / 12 SER A 123
VAL A 122
THR A  27
ILE A  58
SER A  55
 None
 1.41A 2vdyA-5l16A:
undetectable		 2vdyA-5l16A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE
(Leishmania
major) 		4 / 4 LEU A  67
GLY A 115
GLY A 116
THR A  28
 None
 0.91A 3si7A-5l16A:
undetectable		 3si7A-5l16A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE
(Leishmania
major) 		5 / 12 PRO A 244
LEU A 142
VAL A 211
SER A 188
MET A 184
 None
 1.40A 4a84A-5l16A:
undetectable		 4a84A-5l16A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE
(Leishmania
major) 		5 / 12 GLY A 147
ALA A 151
THR A 186
ALA A 252
ASP A 258
 None
 1.43A 4df3A-5l16A:
undetectable		 4df3A-5l16A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE
(Leishmania
major) 		5 / 10 ALA A 151
ILE A 178
ALA A 251
ALA A 252
ILE A 173
 None
 0.97A 4lbgA-5l16A:
undetectable		 4lbgA-5l16A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE
(Leishmania
major) 		5 / 10 GLU A 180
ILE A 178
ALA A 251
ALA A 252
ILE A 173
 None
 1.07A 4lbgA-5l16A:
undetectable		 4lbgA-5l16A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE
(Leishmania
major) 		5 / 9 ALA A 151
ILE A 178
ALA A 251
ALA A 252
ILE A 173
 None
 1.10A 4lbgB-5l16A:
undetectable		 4lbgB-5l16A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE
(Leishmania
major) 		4 / 7 SER A  34
ARG A  93
GLY A  89
GLU A  92
 None
 0.69A 5btaA-5l16A:
undetectable
5btaC-5l16A:
1.5
5btaD-5l16A:
undetectable		 5btaA-5l16A:
21.91
5btaC-5l16A:
21.91
5btaD-5l16A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE
(Leishmania
major) 		4 / 6 SER A  34
ARG A  93
GLY A  89
GLU A  92
 None
 0.68A 5btaA-5l16A:
undetectable
5btaB-5l16A:
undetectable
5btaC-5l16A:
undetectable		 5btaA-5l16A:
21.91
5btaB-5l16A:
22.05
5btaC-5l16A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE
(Leishmania
major) 		4 / 6 SER A  34
ARG A  93
GLY A  89
GLU A  92
 None
 0.68A 5btcA-5l16A:
undetectable
5btcC-5l16A:
1.2
5btcD-5l16A:
undetectable		 5btcA-5l16A:
21.91
5btcC-5l16A:
21.91
5btcD-5l16A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE
(Leishmania
major) 		4 / 6 SER A  34
ARG A  93
GLY A  89
GLU A  92
 None
 0.66A 5btcA-5l16A:
undetectable
5btcB-5l16A:
undetectable
5btcC-5l16A:
undetectable		 5btcA-5l16A:
21.91
5btcB-5l16A:
22.05
5btcC-5l16A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE
(Leishmania
major) 		4 / 7 SER A  34
ARG A  93
GLY A  89
GLU A  92
 None
 0.61A 5btfA-5l16A:
0.6
5btfB-5l16A:
undetectable
5btfC-5l16A:
1.4		 5btfA-5l16A:
21.91
5btfB-5l16A:
22.05
5btfC-5l16A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE
(Leishmania
major) 		4 / 7 SER A  34
ARG A  93
GLY A  89
GLU A  92
 None
 0.69A 5btfA-5l16A:
0.6
5btfC-5l16A:
1.4
5btfD-5l16A:
undetectable		 5btfA-5l16A:
21.91
5btfC-5l16A:
21.91
5btfD-5l16A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 5l16 PUTATIVE
SELENOPHOSPHATE
SYNTHETASE
(Leishmania
major) 		5 / 12 VAL A 211
LEU A 321
GLY A 218
GLY A 147
ILE A 327
 None
 1.15A 5tuiB-5l16A:
undetectable		 5tuiB-5l16A:
22.22