SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		5 / 9 PHE A 361
ILE A 272
ASP A 328
LEU A 329
ASN A 251
 None
 1.47A 1i00B-5l1tA:
undetectable		 1i00B-5l1tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		4 / 6 ARG A 250
GLY A  16
ASP A  13
TYR A 316
 None
 0.81A 1kf6M-5l1tA:
undetectable
1kf6N-5l1tA:
undetectable		 1kf6M-5l1tA:
23.85
1kf6N-5l1tA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		5 / 12 ILE A  14
GLY A 279
GLY A 281
SER A 282
ALA A  18
 None
 1.02A 1vq1B-5l1tA:
undetectable		 1vq1B-5l1tA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		5 / 12 SER A 141
VAL A 396
LEU A 371
LEU A 243
LEU A 373
 None
 1.29A 1ya4B-5l1tA:
undetectable		 1ya4B-5l1tA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		4 / 4 LEU A 368
SER A 130
LEU A 140
LEU A 124
 None
 1.13A 1yajA-5l1tA:
undetectable		 1yajA-5l1tA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		5 / 10 LEU A 249
LEU A 371
LEU A 136
ILE A 394
ALA A 374
 None
 1.14A 2bxeB-5l1tA:
2.4		 2bxeB-5l1tA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		5 / 12 LEU A 247
ILE A 272
PHE A 365
GLU A 271
LEU A 329
 None
 1.30A 2bxfB-5l1tA:
undetectable		 2bxfB-5l1tA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		5 / 12 PHE A 391
GLY A 244
THR A 245
LEU A 273
VAL A 269
 None
 1.12A 2zifA-5l1tA:
undetectable		 2zifA-5l1tA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		5 / 12 PHE A 391
GLY A 244
THR A 245
LEU A 273
VAL A 269
 None
 1.20A 2zifB-5l1tA:
undetectable		 2zifB-5l1tA:
24.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		5 / 12 ILE A  30
ASN A  64
ILE A 294
THR A  51
LEU A 309
 None
 1.20A 3a51D-5l1tA:
42.5		 3a51D-5l1tA:
34.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		3 / 3 HIS A 118
GLU A 122
HIS A 119
 None
 0.76A 3ba0A-5l1tA:
undetectable		 3ba0A-5l1tA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		5 / 12 LEU A 153
VAL A 148
GLY A 349
ILE A 348
VAL A 149
 None
None
HEM  A 402 (-3.6A)
HEM  A 402 ( 4.1A)
None
 1.08A 3gguA-5l1tA:
undetectable		 3gguA-5l1tA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		3 / 3 ARG A 345
MET A  96
ARG A  97
 HEM  A 402 (-3.9A)
HEM  A 402 ( 4.8A)
HEM  A 402 (-3.8A)
 0.95A 3uvvA-5l1tA:
undetectable		 3uvvA-5l1tA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		5 / 9 PHE A 361
ILE A 272
ASP A 328
LEU A 329
ASN A 251
 None
 1.45A 4eb4C-5l1tA:
undetectable		 4eb4C-5l1tA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		5 / 12 GLU A  89
GLY A  83
LEU A  80
SER A  77
HIS A  86
 None
 1.16A 5dpdA-5l1tA:
undetectable		 5dpdA-5l1tA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		5 / 10 ILE A 272
LEU A 248
LEU A 371
LEU A 140
GLU A 117
 None
 1.25A 5y7pG-5l1tA:
undetectable		 5y7pG-5l1tA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGB_B_PQNB844_1
(PSAB)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		5 / 9 ILE A 294
MET A  21
ARG A  32
ALA A  40
ALA A  31
 None
 1.12A 5zgbB-5l1tA:
1.3		 5zgbB-5l1tA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGH_B_PQNB843_1
(PSAB)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		5 / 9 ILE A 294
MET A  21
ARG A  32
ALA A  40
ALA A  31
 None
 1.10A 5zghB-5l1tA:
undetectable		 5zghB-5l1tA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		4 / 6 LEU A 246
VAL A 148
PHE A 391
GLY A 278
 None
 0.87A 6hd4B-5l1tA:
undetectable		 6hd4B-5l1tA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		4 / 8 ASP A  13
TRP A 382
ARG A 250
ASN A 283
 None
None
None
7PF  A 401 (-3.9A)
 1.19A 6hisA-5l1tA:
2.0
6hisB-5l1tA:
2.0		 6hisA-5l1tA:
11.08
6hisB-5l1tA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		4 / 8 ASP A  13
TRP A 382
ARG A 250
ASN A 283
 None
None
None
7PF  A 401 (-3.9A)
 1.19A 6hisB-5l1tA:
2.0
6hisC-5l1tA:
2.0		 6hisB-5l1tA:
11.08
6hisC-5l1tA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		4 / 8 ASP A  13
TRP A 382
ARG A 250
ASN A 283
 None
None
None
7PF  A 401 (-3.9A)
 1.18A 6hisC-5l1tA:
2.0
6hisD-5l1tA:
2.0		 6hisC-5l1tA:
11.08
6hisD-5l1tA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		4 / 8 ASP A  13
TRP A 382
ARG A 250
ASN A 283
 None
None
None
7PF  A 401 (-3.9A)
 1.20A 6hisD-5l1tA:
2.0
6hisE-5l1tA:
2.0		 6hisD-5l1tA:
11.08
6hisE-5l1tA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5l1t PENTALENOLACTONE
SYNTHASE
(Streptomyces
arenae) 		4 / 8 ASN A 283
ASP A  13
TRP A 382
ARG A 250
 7PF  A 401 (-3.9A)
None
None
None
 1.19A 6hisA-5l1tA:
2.0
6hisE-5l1tA:
undetectable		 6hisA-5l1tA:
11.08
6hisE-5l1tA:
11.08