SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l1x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 5l1x HMPV F1 SUBUNIT
(Human
metapneumovirus) 		4 / 5 ARG B 304
ALA B 288
ASP B 306
GLY B 308
 None
 1.18A 1e7bA-5l1xB:
undetectable		 1e7bA-5l1xB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5l1x HMPV F1 SUBUNIT
(Human
metapneumovirus) 		4 / 7 GLN B 312
THR B 317
TYR B 310
GLN B 346
 None
 1.23A 1eiiA-5l1xB:
undetectable		 1eiiA-5l1xB:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 5l1x HMPV F1 SUBUNIT
HMPV F2 SUBUNIT
(Human
metapneumovirus) 		4 / 7 GLU A  51
LEU A  50
VAL B 203
LEU A  81
 None
 0.97A 1hk3A-5l1xA:
undetectable		 1hk3A-5l1xA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5l1x HMPV F1 SUBUNIT
(Human
metapneumovirus) 		4 / 5 GLY B 393
ILE B 399
VAL B 424
SER B 391
 None
 0.95A 1rs7A-5l1xB:
undetectable		 1rs7A-5l1xB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5l1x HMPV F1 SUBUNIT
(Human
metapneumovirus) 		4 / 6 GLY B 393
ILE B 399
VAL B 424
SER B 391
 None
 1.01A 1rs7B-5l1xB:
undetectable		 1rs7B-5l1xB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 5l1x HMPV F1 SUBUNIT
HMPV F2 SUBUNIT
(Human
metapneumovirus) 		4 / 7 ILE B 217
TYR B 269
PHE A  48
GLU B 226
 None
 1.15A 2qebA-5l1xB:
undetectable		 2qebA-5l1xB:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 5l1x HMPV F1 SUBUNIT
HMPV F2 SUBUNIT
(Human
metapneumovirus) 		4 / 7 ILE B 217
TYR B 269
PHE A  48
GLU B 226
 None
 1.16A 2qebB-5l1xB:
undetectable		 2qebB-5l1xB:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5l1x HMPV F1 SUBUNIT
(Human
metapneumovirus) 		5 / 10 PHE B 334
PHE B 276
ASN B 247
ALA B 249
ILE B 217
 None
 1.45A 3t3qD-5l1xB:
undetectable		 3t3qD-5l1xB:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5l1x HMPV F1 SUBUNIT
(Human
metapneumovirus) 		4 / 5 GLY B 393
ILE B 399
VAL B 424
SER B 391
 None
 1.13A 4d33A-5l1xB:
undetectable		 4d33A-5l1xB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5l1x HMPV F1 SUBUNIT
(Human
metapneumovirus) 		4 / 5 GLY B 393
ILE B 399
VAL B 424
SER B 391
 None
 1.13A 4d33B-5l1xB:
undetectable		 4d33B-5l1xB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5l1x HMPV F1 SUBUNIT
(Human
metapneumovirus) 		4 / 6 GLY B 393
ILE B 399
VAL B 424
SER B 391
 None
 1.11A 4d39B-5l1xB:
undetectable		 4d39B-5l1xB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l1x HMPV F1 SUBUNIT
(Human
metapneumovirus) 		4 / 6 GLY B 393
ILE B 399
VAL B 424
SER B 391
 None
 0.93A 4kcnA-5l1xB:
undetectable		 4kcnA-5l1xB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 5l1x HMPV F1 SUBUNIT
HMPV F2 SUBUNIT
(Human
metapneumovirus) 		3 / 3 LEU A  19
ASP B 331
TYR A  35
 None
 0.64A 4qc6B-5l1xA:
undetectable		 4qc6B-5l1xA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5l1x HMPV F1 SUBUNIT
(Human
metapneumovirus) 		4 / 5 ASP B 306
ILE B 352
ASN B 342
TYR B 310
 None
 1.24A 6a93B-5l1xB:
undetectable		 6a93B-5l1xB:
25.54