SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		3 / 3 ASN B 120
ALA B 304
ASN B 187
 None
 0.80A 1n4fA-5l22B:
undetectable		 1n4fA-5l22B:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		4 / 5 GLY B 277
ILE B 279
VAL B 149
SER B  40
 None
 1.00A 1rs7A-5l22B:
undetectable		 1rs7A-5l22B:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		5 / 9 LEU B  73
LEU B  37
LEU B  35
ILE B  34
TYR B 146
 None
 1.20A 2f78A-5l22B:
undetectable		 2f78A-5l22B:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		5 / 9 LEU B  73
LEU B  37
LEU B  35
ILE B  34
TYR B 146
 None
 1.18A 2f78B-5l22B:
undetectable		 2f78B-5l22B:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		5 / 9 LEU B  73
LEU B  37
LEU B  35
ILE B  34
TYR B 146
 None
 1.20A 2f7aA-5l22B:
undetectable		 2f7aA-5l22B:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		5 / 12 ILE B 274
GLY B 260
GLY B 277
ILE B 265
HIS B 154
 None
 0.92A 2fk8A-5l22B:
undetectable		 2fk8A-5l22B:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		5 / 12 LEU B 349
ILE B 522
PRO B 341
PHE B 405
VAL B 409
 None
None
ADP  B 601 (-4.1A)
None
None
 1.07A 2ygqA-5l22B:
undetectable		 2ygqA-5l22B:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		5 / 9 ASP B 493
ILE B 491
ILE B 352
ILE B 356
ILE B 522
 MG  B 602 ( 4.8A)
None
None
None
None
 1.03A 3s45A-5l22B:
undetectable		 3s45A-5l22B:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		5 / 12 ILE B 427
LEU B 418
LEU B 469
ILE B 451
VAL B 450
 None
 0.96A 4c9oA-5l22B:
undetectable		 4c9oA-5l22B:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		4 / 5 GLY B 277
ILE B 279
VAL B 149
SER B  40
 None
 1.11A 4d33A-5l22B:
undetectable		 4d33A-5l22B:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		4 / 6 GLY B 277
ILE B 279
VAL B 149
SER B  40
 None
 1.07A 4d39B-5l22B:
undetectable		 4d39B-5l22B:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		4 / 5 LEU B 375
ILE B 356
ALA B 538
PHE B 548
 None
 1.00A 4dc3B-5l22B:
undetectable		 4dc3B-5l22B:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		5 / 12 GLU B 391
MET B 354
LEU B 334
ILE B 491
ILE B 522
 None
 1.27A 4j26B-5l22B:
undetectable		 4j26B-5l22B:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		4 / 6 GLY B 277
ILE B 279
VAL B 149
SER B  40
 None
 1.06A 4kcnA-5l22B:
undetectable		 4kcnA-5l22B:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		5 / 9 ILE B 332
LEU B 334
THR B 378
ARG B 377
GLY B 381
 None
None
None
ADP  B 601 ( 4.5A)
None
 1.35A 5ifuB-5l22B:
undetectable		 5ifuB-5l22B:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		3 / 3 GLY B 366
GLN B 541
LYS B 372
 None
None
ADP  B 601 (-2.5A)
 0.93A 5imsB-5l22B:
undetectable		 5imsB-5l22B:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		4 / 8 ILE B 137
LEU B 134
MET B  84
LEU B 129
 None
 1.08A 5u4sB-5l22B:
undetectable		 5u4sB-5l22B:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)
(Aquifex
aeolicus) 		3 / 3 SER B 225
LYS B 226
SER B 229
 None
 0.81A 6az3P-5l22B:
undetectable		 6az3P-5l22B:
9.61