SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		3 / 3 ALA A 123
VAL A 128
TRP A 131
 None
 0.88A 1tkqB-5l25A:
undetectable		 1tkqB-5l25A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		5 / 10 ASP A 237
GLY A 239
ILE A  43
MET A 363
ALA A  46
 None
 1.16A 1x7pA-5l25A:
undetectable
1x7pB-5l25A:
undetectable		 1x7pA-5l25A:
19.82
1x7pB-5l25A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		4 / 8 SER A 125
TYR A 103
LEU A 339
LEU A 136
 None
 0.95A 2bfpA-5l25A:
undetectable		 2bfpA-5l25A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		4 / 8 SER A 125
TYR A 103
LEU A 339
LEU A 136
 None
 0.88A 2bfpD-5l25A:
undetectable		 2bfpD-5l25A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		4 / 7 ARG A 222
ALA A  46
ASP A 237
TYR A  42
 None
 1.23A 2e5dA-5l25A:
undetectable
2e5dB-5l25A:
undetectable		 2e5dA-5l25A:
21.63
2e5dB-5l25A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		4 / 7 ASP A 237
TYR A  42
ARG A 222
ALA A  46
 None
 1.24A 2e5dA-5l25A:
undetectable
2e5dB-5l25A:
undetectable		 2e5dA-5l25A:
21.63
2e5dB-5l25A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		5 / 12 MET A 499
ALA A 315
LEU A 318
ALA A 319
THR A 365
 None
 1.26A 2jjpA-5l25A:
undetectable		 2jjpA-5l25A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		4 / 6 ILE A 513
ARG A 512
LEU A 516
LEU A 161
 None
 1.04A 2rlfA-5l25A:
undetectable
2rlfD-5l25A:
undetectable		 2rlfA-5l25A:
5.08
2rlfD-5l25A:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		5 / 12 ILE A  77
GLY A 347
GLY A 350
ALA A  73
ALA A 123
 None
 1.19A 2yvlD-5l25A:
undetectable		 2yvlD-5l25A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		4 / 6 GLU A  56
LYS A 489
ASP A 177
LYS A 173
 None
 1.45A 3pocB-5l25A:
2.1		 3pocB-5l25A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		3 / 3 LYS A  91
SER A 466
GLN A 470
 None
 1.27A 3si7A-5l25A:
undetectable		 3si7A-5l25A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM0_B_KANB302_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		5 / 11 TYR A 103
THR A  99
TYR A 308
LEU A 339
VAL A  95
 None
 1.47A 4em0B-5l25A:
undetectable		 4em0B-5l25A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 158
LEU A 555
ARG A 581
THR A 561
MET A 165
 None
 1.38A 4okxA-5l25A:
undetectable		 4okxA-5l25A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		3 / 3 LEU A 307
ASP A 311
TYR A 308
 None
 0.60A 4qc6B-5l25A:
undetectable		 4qc6B-5l25A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		4 / 7 SER A 354
HIS A  82
GLY A  79
LEU A 339
 None
 1.06A 6btxA-5l25A:
2.7		 6btxA-5l25A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		3 / 3 VAL A 357
ALA A  96
GLN A 360
 None
 0.70A 6gb9A-5l25A:
undetectable		 6gb9A-5l25A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		4 / 6 GLY A 215
LEU A 216
VAL A 250
PHE A 209
 None
 1.03A 6h7lA-5l25A:
undetectable		 6h7lA-5l25A:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5l25 BORON TRANSPORTER 1
(Arabidopsis
thaliana) 		4 / 6 GLY A 215
LEU A 216
VAL A 250
PHE A 209
 None
 1.05A 6h7lB-5l25A:
undetectable		 6h7lB-5l25A:
8.26