SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l2l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DMA_A_NCAA700_0 (EXOTOXIN A)	5l2l	NAB2P (Saccharomyces cerevisiae)	4 / 7	HIS A 430 GLY A 418 TYR A 428 GLU A 413	ZN A 501 (-3.3A) None A G 3 ( 3.9A) ZN A 504 (-2.6A)	0.71A	1dmaA-5l2lA: undetectable	1dmaA-5l2lA: 15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DMA_B_NCAB700_0 (EXOTOXIN A)	5l2l	NAB2P (Saccharomyces cerevisiae)	4 / 6	HIS A 430 GLY A 418 TYR A 428 GLU A 413	ZN A 501 (-3.3A) None A G 3 ( 3.9A) ZN A 504 (-2.6A)	0.88A	1dmaB-5l2lA: undetectable	1dmaB-5l2lA: 15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P9G_A_ACTA42_0 (EAFP 2)	5l2l	NAB2P (Saccharomyces cerevisiae)	3 / 3	CYH A 464 ARG A 477 CYH A 469	ZN A 503 (-2.3A) ZN A 503 ( 4.7A) ZN A 503 (-2.3A)	1.41A	1p9gA-5l2lA: undetectable	1p9gA-5l2lA: 26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IWK_A_CUA1599_0 (NITROUS OXIDE REDUCTASE)	5l2l	NAB2P (Saccharomyces cerevisiae)	3 / 3	CYH A 426 CYH A 415 HIS A 430	ZN A 501 (-2.3A) ZN A 501 (-2.3A) ZN A 501 (-3.3A)	0.82A	2iwkA-5l2lA: undetectable	2iwkA-5l2lA: 7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IWK_A_CUA1599_0 (NITROUS OXIDE REDUCTASE)	5l2l	NAB2P (Saccharomyces cerevisiae)	3 / 3	CYH A 448 CYH A 437 HIS A 452	ZN A 502 (-2.3A) ZN A 502 (-2.4A) ZN A 502 (-3.3A)	0.80A	2iwkA-5l2lA: undetectable	2iwkA-5l2lA: 7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IWK_A_CUA1599_0 (NITROUS OXIDE REDUCTASE)	5l2l	NAB2P (Saccharomyces cerevisiae)	3 / 3	CYH A 469 CYH A 458 HIS A 473	ZN A 503 (-2.3A) ZN A 503 (-2.3A) ZN A 503 (-3.3A)	0.79A	2iwkA-5l2lA: undetectable	2iwkA-5l2lA: 7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IWK_B_CUB1599_0 (NITROUS OXIDE REDUCTASE)	5l2l	NAB2P (Saccharomyces cerevisiae)	3 / 3	CYH A 426 CYH A 415 HIS A 430	ZN A 501 (-2.3A) ZN A 501 (-2.3A) ZN A 501 (-3.3A)	0.80A	2iwkB-5l2lA: undetectable	2iwkB-5l2lA: 7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IWK_B_CUB1599_0 (NITROUS OXIDE REDUCTASE)	5l2l	NAB2P (Saccharomyces cerevisiae)	3 / 3	CYH A 448 CYH A 437 HIS A 452	ZN A 502 (-2.3A) ZN A 502 (-2.4A) ZN A 502 (-3.3A)	0.79A	2iwkB-5l2lA: undetectable	2iwkB-5l2lA: 7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IWK_B_CUB1599_0 (NITROUS OXIDE REDUCTASE)	5l2l	NAB2P (Saccharomyces cerevisiae)	3 / 3	CYH A 469 CYH A 458 HIS A 473	ZN A 503 (-2.3A) ZN A 503 (-2.3A) ZN A 503 (-3.3A)	0.78A	2iwkB-5l2lA: undetectable	2iwkB-5l2lA: 7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DTU_B_CUB1022_0 (CYTOCHROME C OXIDASE SUBUNIT 2)	5l2l	NAB2P (Saccharomyces cerevisiae)	3 / 3	CYH A 469 CYH A 458 HIS A 473	ZN A 503 (-2.3A) ZN A 503 (-2.3A) ZN A 503 (-3.3A)	0.87A	3dtuB-5l2lA: undetectable	3dtuB-5l2lA: 10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DTU_D_CUD3_0 (CYTOCHROME C OXIDASE SUBUNIT 2)	5l2l	NAB2P (Saccharomyces cerevisiae)	3 / 3	CYH A 469 CYH A 458 HIS A 473	ZN A 503 (-2.3A) ZN A 503 (-2.3A) ZN A 503 (-3.3A)	0.86A	3dtuD-5l2lA: undetectable	3dtuD-5l2lA: 10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AE1_A_NCAA1536_0 (DIPHTHERIA TOXIN)	5l2l	NAB2P (Saccharomyces cerevisiae)	4 / 6	HIS A 430 GLY A 418 TYR A 428 GLU A 413	ZN A 501 (-3.3A) None A G 3 ( 3.9A) ZN A 504 (-2.6A)	0.70A	4ae1A-5l2lA: undetectable	4ae1A-5l2lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AE1_B_NCAB1536_0 (DIPHTHERIA TOXIN)	5l2l	NAB2P (Saccharomyces cerevisiae)	4 / 5	HIS A 430 GLY A 418 TYR A 428 GLU A 413	ZN A 501 (-3.3A) None A G 3 ( 3.9A) ZN A 504 (-2.6A)	0.61A	4ae1B-5l2lA: undetectable	4ae1B-5l2lA: 8.72

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DMA_A_NCAA700_0","EXOTOXIN A","5l2l","NAB2P","Saccharomyces cerevisiae",4,"HIS A 430;GLY A 418;TYR A 428;GLU A 413"," ZN A 501 (-3.3A);None;  A G   3 ( 3.9A); ZN A 504 (-2.6A)","0.71A","1dmaA-5l2lA:undetectable","1dmaA-5l2lA:15.57"],["1DMA_B_NCAB700_0","EXOTOXIN A","5l2l","NAB2P","Saccharomyces cerevisiae",4,"HIS A 430;GLY A 418;TYR A 428;GLU A 413"," ZN A 501 (-3.3A);None;  A G   3 ( 3.9A); ZN A 504 (-2.6A)","0.88A","1dmaB-5l2lA:undetectable","1dmaB-5l2lA:15.57"],["1P9G_A_ACTA42_0","EAFP 2","5l2l","NAB2P","Saccharomyces cerevisiae",3,"CYH A 464;ARG A 477;CYH A 469"," ZN A 503 (-2.3A); ZN A 503 ( 4.7A); ZN A 503 (-2.3A)","1.41A","1p9gA-5l2lA:undetectable","1p9gA-5l2lA:26.56"],["2IWK_A_CUA1599_0","NITROUS OXIDE REDUCTASE","5l2l","NAB2P","Saccharomyces cerevisiae",3,"CYH A 426;CYH A 415;HIS A 430"," ZN A 501 (-2.3A); ZN A 501 (-2.3A); ZN A 501 (-3.3A)","0.82A","2iwkA-5l2lA:undetectable","2iwkA-5l2lA:7.73"],["2IWK_A_CUA1599_0","NITROUS OXIDE REDUCTASE","5l2l","NAB2P","Saccharomyces cerevisiae",3,"CYH A 448;CYH A 437;HIS A 452"," ZN A 502 (-2.3A); ZN A 502 (-2.4A); ZN A 502 (-3.3A)","0.80A","2iwkA-5l2lA:undetectable","2iwkA-5l2lA:7.73"],["2IWK_A_CUA1599_0","NITROUS OXIDE REDUCTASE","5l2l","NAB2P","Saccharomyces cerevisiae",3,"CYH A 469;CYH A 458;HIS A 473"," ZN A 503 (-2.3A); ZN A 503 (-2.3A); ZN A 503 (-3.3A)","0.79A","2iwkA-5l2lA:undetectable","2iwkA-5l2lA:7.73"],["2IWK_B_CUB1599_0","NITROUS OXIDE REDUCTASE","5l2l","NAB2P","Saccharomyces cerevisiae",3,"CYH A 426;CYH A 415;HIS A 430"," ZN A 501 (-2.3A); ZN A 501 (-2.3A); ZN A 501 (-3.3A)","0.80A","2iwkB-5l2lA:undetectable","2iwkB-5l2lA:7.73"],["2IWK_B_CUB1599_0","NITROUS OXIDE REDUCTASE","5l2l","NAB2P","Saccharomyces cerevisiae",3,"CYH A 448;CYH A 437;HIS A 452"," ZN A 502 (-2.3A); ZN A 502 (-2.4A); ZN A 502 (-3.3A)","0.79A","2iwkB-5l2lA:undetectable","2iwkB-5l2lA:7.73"],["2IWK_B_CUB1599_0","NITROUS OXIDE REDUCTASE","5l2l","NAB2P","Saccharomyces cerevisiae",3,"CYH A 469;CYH A 458;HIS A 473"," ZN A 503 (-2.3A); ZN A 503 (-2.3A); ZN A 503 (-3.3A)","0.78A","2iwkB-5l2lA:undetectable","2iwkB-5l2lA:7.73"],["3DTU_B_CUB1022_0","CYTOCHROME C OXIDASE SUBUNIT 2","5l2l","NAB2P","Saccharomyces cerevisiae",3,"CYH A 469;CYH A 458;HIS A 473"," ZN A 503 (-2.3A); ZN A 503 (-2.3A); ZN A 503 (-3.3A)","0.87A","3dtuB-5l2lA:undetectable","3dtuB-5l2lA:10.65"],["3DTU_D_CUD3_0","CYTOCHROME C OXIDASE SUBUNIT 2","5l2l","NAB2P","Saccharomyces cerevisiae",3,"CYH A 469;CYH A 458;HIS A 473"," ZN A 503 (-2.3A); ZN A 503 (-2.3A); ZN A 503 (-3.3A)","0.86A","3dtuD-5l2lA:undetectable","3dtuD-5l2lA:10.65"],["4AE1_A_NCAA1536_0","DIPHTHERIA TOXIN","5l2l","NAB2P","Saccharomyces cerevisiae",4,"HIS A 430;GLY A 418;TYR A 428;GLU A 413"," ZN A 501 (-3.3A);None;  A G   3 ( 3.9A); ZN A 504 (-2.6A)","0.70A","4ae1A-5l2lA:undetectable","4ae1A-5l2lA:undetectable"],["4AE1_B_NCAB1536_0","DIPHTHERIA TOXIN","5l2l","NAB2P","Saccharomyces cerevisiae",4,"HIS A 430;GLY A 418;TYR A 428;GLU A 413"," ZN A 501 (-3.3A);None;  A G   3 ( 3.9A); ZN A 504 (-2.6A)","0.61A","4ae1B-5l2lA:undetectable","4ae1B-5l2lA:8.72"]]