SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l2q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_A_AZMA400_1
(CARBONIC ANHYDRASE
XIV)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		5 / 10 HIS C 195
VAL C 194
LEU C 223
LEU C  96
THR C  92
 None
 1.36A 1rj6A-5l2qC:
undetectable		 1rj6A-5l2qC:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		5 / 10 HIS C 195
VAL C 194
LEU C 223
LEU C  96
THR C  92
 None
 1.34A 1rj6B-5l2qC:
undetectable		 1rj6B-5l2qC:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 8 GLY C  86
ILE C  49
VAL C  46
PRO C  45
 None
 0.94A 1rxcB-5l2qC:
undetectable		 1rxcB-5l2qC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 7 GLY C  86
ILE C  49
VAL C  46
PRO C  45
 None
 1.02A 1rxcC-5l2qC:
undetectable		 1rxcC-5l2qC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 7 GLY C  86
ILE C  49
VAL C  46
PRO C  45
 None
 0.95A 1rxcD-5l2qC:
undetectable		 1rxcD-5l2qC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 8 GLY C  86
ILE C  49
VAL C  46
PRO C  45
 None
 0.95A 1rxcE-5l2qC:
undetectable		 1rxcE-5l2qC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 7 GLY C  86
ILE C  49
VAL C  46
PRO C  45
 None
 0.91A 1rxcF-5l2qC:
undetectable		 1rxcF-5l2qC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 8 GLY C  86
ILE C  49
VAL C  46
PRO C  45
 None
 0.96A 1rxcI-5l2qC:
undetectable		 1rxcI-5l2qC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 8 GLY C  86
ILE C  49
VAL C  46
PRO C  45
 None
 0.94A 1rxcK-5l2qC:
undetectable		 1rxcK-5l2qC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 7 GLY C  86
ILE C  49
VAL C  46
PRO C  45
 None
 0.92A 1rxcL-5l2qC:
undetectable		 1rxcL-5l2qC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		5 / 9 LEU C  96
LEU C  97
PHE C 217
LEU C 188
ILE C 193
 None
 0.95A 2f78A-5l2qC:
undetectable		 2f78A-5l2qC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		5 / 9 LEU C  96
LEU C  97
PHE C 217
LEU C 188
ILE C 193
 None
 0.99A 2f78B-5l2qC:
undetectable		 2f78B-5l2qC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		5 / 9 LEU C  96
LEU C  97
PHE C 217
LEU C 188
ILE C 193
 None
 1.04A 2f7aA-5l2qC:
undetectable		 2f7aA-5l2qC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		5 / 10 LEU C  96
LEU C  97
PHE C 217
LEU C 188
ILE C 193
 None
 1.00A 2f8dB-5l2qC:
undetectable		 2f8dB-5l2qC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		5 / 12 HIS C 189
GLY C 220
LEU C 223
ASP C 197
LEU C  96
 None
 1.23A 3cjtK-5l2qC:
undetectable		 3cjtK-5l2qC:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		5 / 12 HIS C 189
GLY C 220
LEU C 223
ASP C 197
LEU C  97
 None
 1.20A 3cjtK-5l2qC:
undetectable		 3cjtK-5l2qC:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 6 VAL C 106
ILE C 193
HIS C 195
ILE C 214
 None
 0.53A 3hegA-5l2qC:
19.1		 3hegA-5l2qC:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 7 ILE C 278
GLU C 281
PHE C 283
VAL C 262
 None
 1.12A 4a97A-5l2qC:
undetectable		 4a97A-5l2qC:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 7 ILE C 278
GLU C 281
PHE C 283
VAL C 262
 None
 1.08A 4a97D-5l2qC:
undetectable		 4a97D-5l2qC:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 8 GLY C  86
ILE C  49
VAL C  46
PRO C  45
 None
 0.89A 4e1vA-5l2qC:
undetectable		 4e1vA-5l2qC:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 7 GLY C  86
ILE C  49
VAL C  46
PRO C  45
 None
 0.91A 4e1vB-5l2qC:
undetectable		 4e1vB-5l2qC:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 8 GLY C  86
ILE C  49
VAL C  46
PRO C  45
 None
 0.89A 4e1vC-5l2qC:
undetectable		 4e1vC-5l2qC:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 8 GLY C  86
ILE C  49
VAL C  46
PRO C  45
 None
 0.90A 4e1vD-5l2qC:
undetectable		 4e1vD-5l2qC:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 8 GLY C  86
ILE C  49
VAL C  46
PRO C  45
 None
 0.93A 4e1vE-5l2qC:
undetectable		 4e1vE-5l2qC:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 8 GLY C  86
ILE C  49
VAL C  46
PRO C  45
 None
 0.89A 4e1vG-5l2qC:
undetectable		 4e1vG-5l2qC:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 8 GLY C  86
ILE C  49
VAL C  46
PRO C  45
 None
 0.90A 4e1vH-5l2qC:
undetectable		 4e1vH-5l2qC:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		5 / 12 TYR C 239
LEU C 200
ILE C 164
ASP C 296
GLY C 270
 None
 1.25A 4hfpB-5l2qC:
undetectable		 4hfpB-5l2qC:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		5 / 12 VAL C 185
LEU C 328
LEU C 264
ILE C 177
LEU C 159
 None
 1.13A 4ky8E-5l2qC:
undetectable		 4ky8E-5l2qC:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens) 		4 / 4 VAL C 263
ILE C 177
ASN C 158
VAL C 163
 None
 1.21A 5ajqA-5l2qC:
21.4		 5ajqA-5l2qC:
27.57