SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l2r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		3 / 3 GLU A 226
TYR A 224
PHE A 239
 None
 0.69A 1eqbB-5l2rA:
undetectable		 1eqbB-5l2rA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		3 / 3 GLU A 226
TYR A 224
PHE A 239
 None
 0.70A 1eqbA-5l2rA:
undetectable		 1eqbA-5l2rA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		3 / 3 GLU A 226
TYR A 224
PHE A 239
 None
 0.69A 1eqbD-5l2rA:
undetectable		 1eqbD-5l2rA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		3 / 3 GLU A 226
TYR A 224
PHE A 239
 None
 0.70A 1eqbC-5l2rA:
undetectable		 1eqbC-5l2rA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		5 / 12 GLN A 316
GLY A 314
GLY A  97
ALA A 115
VAL A 114
 None
 1.12A 1jg4A-5l2rA:
undetectable		 1jg4A-5l2rA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		4 / 7 SER A 132
PRO A 131
ALA A 517
ALA A 348
 None
None
None
SF4  A 608 (-3.5A)
 1.01A 1k5qA-5l2rA:
undetectable
1k5qB-5l2rA:
undetectable		 1k5qA-5l2rA:
14.61
1k5qB-5l2rA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		3 / 3 SER A 217
GLY A 216
ARG A 350
 SF4  A 608 ( 4.5A)
LMR  A 601 (-3.1A)
SF4  A 608 ( 4.5A)
 0.66A 1t9wA-5l2rA:
undetectable		 1t9wA-5l2rA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		4 / 4 LEU A 159
SER A 160
TYR A 158
LEU A  75
 None
 1.30A 1xz1A-5l2rA:
undetectable		 1xz1A-5l2rA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		4 / 4 LEU A 159
SER A 160
TYR A 158
LEU A  75
 None
 1.30A 1xz3A-5l2rA:
undetectable		 1xz3A-5l2rA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		4 / 8 PRO A 446
LEU A 510
GLY A 511
LEU A 413
 None
 0.74A 1ya4A-5l2rA:
undetectable		 1ya4A-5l2rA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		4 / 7 PRO A 446
LEU A 510
GLY A 511
LEU A 413
 None
 0.79A 1ya4B-5l2rA:
undetectable		 1ya4B-5l2rA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		4 / 6 GLU A 367
TYR A 373
ASP A  93
ARG A 279
 None
 1.21A 2a3bB-5l2rA:
undetectable		 2a3bB-5l2rA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y4N_B_PACB503_0
(PHENYLACETATE-COENZY
ME A LIGASE)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		4 / 4 SER A 347
GLY A 248
GLY A 492
LYS A 491
 None
None
None
LMR  A 601 ( 2.6A)
 0.92A 2y4nB-5l2rA:
2.3		 2y4nB-5l2rA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		5 / 11 VAL A 273
ILE A 261
GLY A 262
LEU A 259
LEU A 342
 None
 1.16A 3kw2A-5l2rA:
2.5		 3kw2A-5l2rA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		6 / 12 ALA A 308
GLY A 318
GLY A 312
ASP A 109
ARG A 112
TYR A 321
 None
 1.44A 3o7wA-5l2rA:
undetectable		 3o7wA-5l2rA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		4 / 5 ILE A 329
THR A 272
THR A 269
PHE A  35
 None
None
None
GOL  A 607 (-4.3A)
 1.16A 3snfA-5l2rA:
undetectable		 3snfA-5l2rA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		5 / 12 GLY A 214
GLY A 137
ASP A 135
ALA A 218
ASN A 219
 SF4  A 608 (-3.4A)
None
LMR  A 601 ( 3.6A)
None
LMR  A 602 (-4.5A)
 0.93A 3t7sA-5l2rA:
undetectable		 3t7sA-5l2rA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		5 / 12 GLY A 214
GLY A 137
ASP A 135
ALA A 218
ASN A 219
 SF4  A 608 (-3.4A)
None
LMR  A 601 ( 3.6A)
None
LMR  A 602 (-4.5A)
 0.94A 3t7sB-5l2rA:
undetectable		 3t7sB-5l2rA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		5 / 12 GLY A 214
GLY A 137
ASP A 135
ALA A 218
ASN A 219
 SF4  A 608 (-3.4A)
None
LMR  A 601 ( 3.6A)
None
LMR  A 602 (-4.5A)
 0.87A 3t7sD-5l2rA:
undetectable		 3t7sD-5l2rA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		4 / 5 LEU A 520
PHE A 464
PRO A 466
ALA A 450
 None
 1.38A 3vm4A-5l2rA:
undetectable		 3vm4A-5l2rA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		3 / 3 ASP A 155
GLU A 154
GLY A 152
 None
 0.63A 3w9tA-5l2rA:
undetectable		 3w9tA-5l2rA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		6 / 11 LEU A 489
ALA A 551
VAL A 389
VAL A 411
PHE A 549
LEU A 391
 None
 1.01A 4agdA-5l2rA:
undetectable		 4agdA-5l2rA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		5 / 12 LEU A 244
ILE A 240
ILE A 257
ALA A 258
GLY A 262
 None
 1.10A 4enhA-5l2rA:
undetectable		 4enhA-5l2rA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		4 / 8 PHE A 208
ILE A 361
PHE A 210
GLY A 162
 None
 1.01A 4fgjA-5l2rA:
undetectable
4fgjB-5l2rA:
undetectable		 4fgjA-5l2rA:
17.58
4fgjB-5l2rA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		5 / 12 GLY A 216
GLY A 215
GLY A 214
SER A 345
ALA A 250
 LMR  A 601 (-3.1A)
LMR  A 601 ( 4.3A)
SF4  A 608 (-3.4A)
None
LMR  A 602 ( 3.8A)
 0.97A 4htfA-5l2rA:
undetectable		 4htfA-5l2rA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		5 / 12 GLY A 216
GLY A 215
GLY A 214
SER A 345
ALA A 250
 LMR  A 601 (-3.1A)
LMR  A 601 ( 4.3A)
SF4  A 608 (-3.4A)
None
LMR  A 602 ( 3.8A)
 0.99A 4htfB-5l2rA:
undetectable		 4htfB-5l2rA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		4 / 6 ASN A 493
TYR A 255
LEU A 247
PHE A 322
 None
 1.22A 4twdI-5l2rA:
undetectable
4twdJ-5l2rA:
undetectable		 4twdI-5l2rA:
19.93
4twdJ-5l2rA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		4 / 6 ALA A 371
GLN A 372
LEU A 374
LEU A  95
 None
 1.19A 4xp3A-5l2rA:
undetectable		 4xp3A-5l2rA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		5 / 12 LEU A 531
VAL A 541
LEU A 489
ILE A 447
VAL A 546
 None
 1.04A 4y0pA-5l2rA:
undetectable		 4y0pA-5l2rA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		5 / 12 GLY A 465
TYR A 449
SER A 524
ALA A 517
ASN A 121
 None
 1.42A 4ymgA-5l2rA:
undetectable		 4ymgA-5l2rA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		5 / 12 GLY A 465
TYR A 449
SER A 524
ALA A 517
ASN A 121
 None
 1.38A 4ymgB-5l2rA:
undetectable		 4ymgB-5l2rA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		4 / 8 PHE A  89
SER A 132
ALA A 125
LEU A 366
 None
 1.08A 5dzkd-5l2rA:
undetectable
5dzkr-5l2rA:
undetectable		 5dzkd-5l2rA:
15.89
5dzkr-5l2rA:
1.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		5 / 10 ALA A 258
LEU A 342
LEU A 244
GLU A 301
ILE A 240
 None
 1.10A 5v02B-5l2rA:
undetectable
5v02R-5l2rA:
undetectable		 5v02B-5l2rA:
10.26
5v02R-5l2rA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		4 / 8 GLY A 483
GLU A 440
ILE A 395
GLN A 400
 None
 1.00A 5vlmD-5l2rA:
undetectable		 5vlmD-5l2rA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5l2r FUMARATE HYDRATASE
(Leishmania
major) 		3 / 3 SER A 485
HIS A 425
TYR A 449
 None
 1.03A 5y2tA-5l2rA:
undetectable		 5y2tA-5l2rA:
undetectable