SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l2v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5l2v CHITIN-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 5 GLY A 145
ILE A   4
VAL A  32
SER A   9
 None
 1.21A 1rs7A-5l2vA:
undetectable		 1rs7A-5l2vA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5l2v CHITIN-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 8 TRP A  79
TYR A   3
TRP A 147
LEU A 126
 None
P33  A 202 (-4.8A)
None
None
 1.49A 1uw6G-5l2vA:
undetectable
1uw6H-5l2vA:
undetectable		 1uw6G-5l2vA:
21.23
1uw6H-5l2vA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5l2v CHITIN-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 6 ALA A 127
TYR A   3
ILE A   4
LEU A  81
 None
P33  A 202 (-4.8A)
None
None
 0.96A 1xvaA-5l2vA:
undetectable
1xvaB-5l2vA:
undetectable		 1xvaA-5l2vA:
20.13
1xvaB-5l2vA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 5l2v CHITIN-BINDING
PROTEIN
(Listeria
monocytogenes) 		5 / 9 LEU A  13
ILE A  18
GLY A  17
SER A   9
SER A   5
 None
None
P33  A 202 ( 3.7A)
None
None
 1.09A 2qmmA-5l2vA:
undetectable		 2qmmA-5l2vA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5l2v CHITIN-BINDING
PROTEIN
(Listeria
monocytogenes) 		5 / 11 ILE A 116
LEU A  75
ILE A 131
SER A   5
ILE A   4
 None
 1.01A 2w9sA-5l2vA:
undetectable		 2w9sA-5l2vA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 5l2v CHITIN-BINDING
PROTEIN
(Listeria
monocytogenes) 		5 / 12 TYR A 157
GLY A 145
LEU A 144
ALA A 127
LEU A  81
 None
 1.16A 3vywB-5l2vA:
undetectable		 3vywB-5l2vA:
19.17