SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 5l2x DNA-DIRECTED
PRIMASE/POLYMERASE
PROTEIN
(Homo
sapiens) 		4 / 4 THR A 307
GLY A 127
ASP A 126
ALA A 132
 None
 0.84A 1sg9A-5l2xA:
undetectable		 1sg9A-5l2xA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 5l2x DNA-DIRECTED
PRIMASE/POLYMERASE
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 134
ILE A 135
CYH A 139
TYR A 284
CYH A 150
 None
 0.80A 2bxeB-5l2xA:
undetectable		 2bxeB-5l2xA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 5l2x DNA-DIRECTED
PRIMASE/POLYMERASE
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 134
ILE A 135
CYH A 139
TYR A 284
CYH A 150
 None
 0.83A 2bxfB-5l2xA:
undetectable		 2bxfB-5l2xA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5l2x DNA-DIRECTED
PRIMASE/POLYMERASE
PROTEIN
(Homo
sapiens) 		4 / 8 LEU A 134
LEU A 142
VAL A 185
GLY A 186
 None
 1.00A 2po5A-5l2xA:
undetectable		 2po5A-5l2xA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5l2x DNA-DIRECTED
PRIMASE/POLYMERASE
PROTEIN
(Homo
sapiens) 		3 / 3 TYR A 293
SER A 295
TRP A  87
 None
 1.02A 5n8jB-5l2xA:
undetectable		 5n8jB-5l2xA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5l2x DNA-DIRECTED
PRIMASE/POLYMERASE
PROTEIN
(Homo
sapiens) 		3 / 3 TYR A 293
SER A 295
TRP A  87
 None
 0.96A 5n8jA-5l2xA:
undetectable		 5n8jA-5l2xA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5l2x DNA-DIRECTED
PRIMASE/POLYMERASE
PROTEIN
(Homo
sapiens) 		3 / 3 TYR A 293
SER A 295
TRP A  87
 None
 0.99A 5n8jD-5l2xA:
undetectable		 5n8jD-5l2xA:
20.96