SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l35'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		5 / 12 ASP A 148
PRO A 423
GLY A 137
SER A 138
THR A 141
 None
 1.24A 1g60A-5l35A:
undetectable		 1g60A-5l35A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		4 / 8 PHE A 359
ASN A 356
GLU A 163
GLY A 164
 None
 1.09A 1ykiA-5l35A:
undetectable
1ykiB-5l35A:
undetectable		 1ykiA-5l35A:
19.00
1ykiB-5l35A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		4 / 8 PHE A 359
ASN A 356
GLU A 163
GLY A 164
 None
 1.09A 1ykiA-5l35A:
undetectable
1ykiB-5l35A:
undetectable		 1ykiA-5l35A:
19.00
1ykiB-5l35A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		4 / 8 PHE A 359
ASN A 356
GLU A 163
GLY A 164
 None
 1.08A 1ykiC-5l35A:
undetectable
1ykiD-5l35A:
undetectable		 1ykiC-5l35A:
19.00
1ykiD-5l35A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		3 / 3 ASN A  72
LEU A  74
HIS A  54
 None
 0.87A 2q6fB-5l35A:
undetectable		 2q6fB-5l35A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		5 / 10 VAL A 311
PHE A 247
SER A 244
ASN A 131
ALA A 295
 None
 1.34A 2x2iB-5l35A:
undetectable		 2x2iB-5l35A:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		4 / 7 VAL A 268
GLN A 418
GLY A 416
LEU A 156
 None
 0.89A 3bjwB-5l35A:
undetectable		 3bjwB-5l35A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		4 / 6 VAL A 268
GLN A 418
GLY A 416
LEU A 156
 None
 0.87A 3bjwE-5l35A:
undetectable		 3bjwE-5l35A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		5 / 12 ALA A 299
VAL A 268
PHE A 270
VAL A 341
LEU A 251
 None
 1.17A 3hkuA-5l35A:
undetectable		 3hkuA-5l35A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		5 / 12 ALA A 295
GLY A 417
GLY A 416
VAL A 268
VAL A 333
 None
 1.00A 3m6wA-5l35A:
undetectable		 3m6wA-5l35A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		5 / 12 ASN A 352
VAL A  26
LEU A 211
ILE A 143
PHE A 419
 None
 1.39A 3mnoA-5l35A:
undetectable		 3mnoA-5l35A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		5 / 12 ASN A 352
VAL A  26
LEU A 211
ILE A 143
PHE A 419
 None
 1.36A 3mnpA-5l35A:
undetectable		 3mnpA-5l35A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		4 / 5 LEU A 120
ARG A  33
LEU A 404
PRO A 406
 None
 1.37A 3onnA-5l35A:
undetectable		 3onnA-5l35A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		4 / 6 TRP A 275
LEU A 276
SER A 330
THR A 273
 None
 1.41A 3ropA-5l35A:
undetectable		 3ropA-5l35A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		4 / 7 ARG A  52
ILE A  75
ASN A 239
GLN A 278
 None
 1.10A 4g0vA-5l35A:
undetectable		 4g0vA-5l35A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		4 / 7 TYR A 285
GLN A 332
THR A 321
THR A 280
 None
 0.99A 4mbsA-5l35A:
undetectable		 4mbsA-5l35A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		3 / 3 ARG A 386
ASP A 403
ARG A 401
 None
 0.53A 4wq4B-5l35A:
undetectable		 4wq4B-5l35A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		3 / 3 CYH A 360
MET A 128
ASN A 131
 None
 1.09A 5qh8A-5l35A:
undetectable		 5qh8A-5l35A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		4 / 4 PHE A 359
LEU A 216
LEU A 124
VAL A 169
 None
 1.17A 5xxiA-5l35A:
undetectable		 5xxiA-5l35A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		4 / 6 GLY A 206
SER A 154
THR A 152
VAL A 149
 None
 1.24A 5ysiA-5l35A:
undetectable		 5ysiA-5l35A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5l35 GENE 5 PROTEIN
(Shigella
virus
Sf6) 		5 / 9 ASN A  85
ILE A  40
SER A 364
GLY A 363
THR A  44
 None
 1.39A 6awpA-5l35A:
undetectable		 6awpA-5l35A:
22.18