SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l3q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 6 LEU B 623
TRP B 441
PHE B 613
VAL B 586
 None
 1.28A 1ibgH-5l3qB:
undetectable		 1ibgH-5l3qB:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 11 LEU B 393
VAL B 354
VAL B 597
GLY B 598
LEU B 362
 None
 1.45A 1lwcA-5l3qB:
undetectable		 1lwcA-5l3qB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 9 LEU B 393
VAL B 354
VAL B 597
GLY B 598
LEU B 362
 None
 1.35A 1lwfA-5l3qB:
undetectable		 1lwfA-5l3qB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 THR B 433
GLY B 430
GLY B 428
VAL B 550
GLY B 617
 GNP  B 705 (-3.6A)
GNP  B 705 (-3.1A)
GNP  B 705 (-3.4A)
None
GNP  B 705 (-3.3A)
 0.96A 1n2xB-5l3qB:
3.6		 1n2xB-5l3qB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 10 GLY B 430
GLU B 552
VAL B 429
GLY B 428
THR B 433
 GNP  B 705 (-3.1A)
None
GNP  B 705 (-4.1A)
GNP  B 705 (-3.4A)
GNP  B 705 (-3.6A)
 1.24A 1pwyE-5l3qB:
undetectable		 1pwyE-5l3qB:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 10 LEU B 393
ALA B 359
ILE B 358
GLY B 598
HIS B 348
 None
 1.41A 2b17A-5l3qB:
undetectable		 2b17A-5l3qB:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 GLY B 523
GLY B 551
GLY B 430
GLY B 428
THR B 588
 GNP  B 705 (-3.7A)
None
GNP  B 705 (-3.1A)
GNP  B 705 (-3.4A)
GNP  B 705 ( 4.6A)
 0.81A 2oxtB-5l3qB:
undetectable		 2oxtB-5l3qB:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 10 ASP B 591
ILE B 585
THR B 592
ILE B 582
GLY B 430
 GNP  B 705 (-2.9A)
None
GNP  B 705 ( 4.7A)
None
GNP  B 705 (-3.1A)
 1.19A 2v0mA-5l3qB:
undetectable		 2v0mA-5l3qB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 11 LEU B 587
VAL B 614
SER B 602
ILE B 611
ALA B 630
 None
 1.14A 2zbzA-5l3qB:
undetectable		 2zbzA-5l3qB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 11 VAL B 597
LEU B 587
VAL B 614
SER B 602
ILE B 611
 None
 1.18A 2zbzA-5l3qB:
undetectable		 2zbzA-5l3qB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 10 LEU B 393
VAL B 354
VAL B 597
GLY B 598
LEU B 362
 None
 1.43A 3qipA-5l3qB:
undetectable		 3qipA-5l3qB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 LEU B 397
GLY B 551
ALA B 553
LEU B 626
GLY B 556
 None
 0.95A 4dc3A-5l3qB:
2.1		 4dc3A-5l3qB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLW_A_TESA1001_1
(ANDROGEN RECEPTOR)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 LEU B 442
ASN B 445
GLY B 446
MET B 486
VAL B 487
 None
 1.18A 4hlwA-5l3qB:
undetectable		 4hlwA-5l3qB:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 7 LEU B 635
GLY B 598
ALA B 599
SER B 602
 None
 0.87A 5f1aB-5l3qB:
undetectable		 5f1aB-5l3qB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 11 LEU B 393
VAL B 354
VAL B 597
GLY B 598
LEU B 362
 None
 1.39A 5hbmA-5l3qB:
undetectable		 5hbmA-5l3qB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 6 GLY B 615
THR B 588
GLY B 551
ASN B 434
 GNP  B 705 (-3.6A)
GNP  B 705 ( 4.6A)
None
GNP  B 705 (-3.7A)
 0.83A 5k4pA-5l3qB:
4.6		 5k4pA-5l3qB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 4 THR B 521
VAL B 519
PRO B 544
THR B 422
 None
 1.46A 5mthA-5l3qB:
undetectable
5mthH-5l3qB:
undetectable		 5mthA-5l3qB:
16.22
5mthH-5l3qB:
16.22