SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		5 / 9 GLY A 240
ASP A 213
ILE A  99
PHE A 269
ILE A 243
 None
 1.20A 1cetA-5l3sA:
3.4		 1cetA-5l3sA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 5l3s SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Sulfolobus
acidocaldarius) 		5 / 10 LEU B 106
VAL B 111
ILE B 119
GLU B 152
VAL B 363
 None
 1.07A 1cqpA-5l3sB:
undetectable
1cqpB-5l3sB:
2.0		 1cqpA-5l3sB:
23.00
1cqpB-5l3sB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 6 LEU B 302
ASP A  38
LEU B 291
HIS B 307
 None
 1.18A 1errB-5l3sB:
undetectable		 1errB-5l3sB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Sulfolobus
solfataricus;
Sulfolobus
acidocaldarius) 		5 / 10 ARG A 136
ALA B 215
GLY A 147
ALA B 214
THR A 110
 GNP  B 401 (-3.2A)
None
None
GOL  A 306 (-4.1A)
MG  A 302 ( 3.1A)
 1.22A 1gtnB-5l3sA:
undetectable
1gtnC-5l3sA:
undetectable		 1gtnB-5l3sA:
17.33
1gtnC-5l3sA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Sulfolobus
solfataricus;
Sulfolobus
acidocaldarius) 		5 / 10 ARG A 136
ALA B 215
GLY A 147
ALA B 214
THR A 110
 GNP  B 401 (-3.2A)
None
None
GOL  A 306 (-4.1A)
MG  A 302 ( 3.1A)
 1.20A 1gtnH-5l3sA:
undetectable
1gtnI-5l3sA:
undetectable		 1gtnH-5l3sA:
17.33
1gtnI-5l3sA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		4 / 7 PHE A  82
PHE A 287
VAL A  39
LEU A  78
 None
 1.03A 1hk3A-5l3sA:
4.2		 1hk3A-5l3sA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		4 / 6 LEU A 101
LEU A 129
GLY A 128
ILE A 181
 None
 0.88A 1mt1G-5l3sA:
undetectable
1mt1J-5l3sA:
undetectable		 1mt1G-5l3sA:
10.96
1mt1J-5l3sA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		4 / 8 LEU A  78
VAL A  39
GLY A 254
LEU A  47
 None
 1.01A 1s1xA-5l3sA:
undetectable		 1s1xA-5l3sA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 5 LEU B 302
ASP A  38
LEU B 291
HIS B 307
 None
 1.14A 2jfaA-5l3sB:
undetectable		 2jfaA-5l3sB:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		4 / 7 ILE A 181
LEU A 101
LEU A 129
GLY A 128
 None
 0.86A 2qqcD-5l3sA:
undetectable
2qqcE-5l3sA:
undetectable		 2qqcD-5l3sA:
17.18
2qqcE-5l3sA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		4 / 8 ILE A 181
LEU A 101
LEU A 129
GLY A 128
 None
 0.87A 2qqdB-5l3sA:
undetectable
2qqdC-5l3sA:
undetectable		 2qqdB-5l3sA:
16.49
2qqdC-5l3sA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 5 LEU B 302
ASP A  38
LEU B 291
HIS B 307
 None
 1.17A 2qxsA-5l3sB:
undetectable		 2qxsA-5l3sB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 5 LEU B 302
ASP A  38
LEU B 291
HIS B 307
 None
 1.16A 2qxsB-5l3sB:
undetectable		 2qxsB-5l3sB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 5l3s SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Sulfolobus
acidocaldarius) 		5 / 12 LEU B 102
ILE B  99
LEU B 123
ASP B 122
SER B 112
 None
 1.18A 3ko0M-5l3sB:
undetectable
3ko0N-5l3sB:
undetectable
3ko0O-5l3sB:
undetectable
3ko0P-5l3sB:
undetectable		 3ko0M-5l3sB:
14.58
3ko0N-5l3sB:
14.58
3ko0O-5l3sB:
14.58
3ko0P-5l3sB:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 5l3s SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Sulfolobus
acidocaldarius) 		5 / 12 SER B 112
LEU B 123
ASP B 122
LEU B 102
ILE B  99
 None
 1.15A 3ko0M-5l3sB:
undetectable
3ko0N-5l3sB:
undetectable
3ko0O-5l3sB:
undetectable
3ko0P-5l3sB:
undetectable		 3ko0M-5l3sB:
14.58
3ko0N-5l3sB:
14.58
3ko0O-5l3sB:
14.58
3ko0P-5l3sB:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		4 / 6 ALA A 167
ILE A 164
VAL A 134
ASN A 162
 None
 1.21A 3nneG-5l3sA:
2.8		 3nneG-5l3sA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		4 / 6 GLU A  53
LYS A  57
LYS A  50
GLU A  77
 None
 1.49A 4a7tF-5l3sA:
undetectable		 4a7tF-5l3sA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		4 / 6 THR A 111
GLY A 114
ILE A 150
LEU A 279
 GNP  A 301 (-3.7A)
None
None
None
 0.94A 4ac9C-5l3sA:
7.4		 4ac9C-5l3sA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		4 / 6 THR A 111
GLY A 114
ILE A 150
LEU A 279
 GNP  A 301 (-3.7A)
None
None
None
 1.02A 4acbC-5l3sA:
7.1		 4acbC-5l3sA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		5 / 11 GLY A 253
GLY A 254
ILE A 222
GLY A 249
ILE A 244
 None
 1.18A 4qoiA-5l3sA:
3.1
4qoiB-5l3sA:
3.2		 4qoiA-5l3sA:
20.60
4qoiB-5l3sA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		4 / 7 ILE A 267
PHE A 287
VAL A 242
ILE A 218
 None
 0.96A 4zzbC-5l3sA:
2.5
4zzbD-5l3sA:
2.6		 4zzbC-5l3sA:
22.95
4zzbD-5l3sA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		5 / 12 GLY B 348
ILE A 244
GLY A 253
GLY A 255
HIS A 190
 GNP  B 401 (-3.4A)
None
None
None
GNP  B 401 (-4.4A)
 0.99A 5eqbA-5l3sB:
undetectable		 5eqbA-5l3sB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5l3s SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Sulfolobus
acidocaldarius) 		5 / 12 VAL B 115
GLU B 114
LEU B 319
LEU B 334
LEU B 293
 None
 1.14A 5hnwB-5l3sB:
undetectable		 5hnwB-5l3sB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5l3s SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Sulfolobus
acidocaldarius) 		5 / 12 VAL B 115
GLU B 114
LEU B 319
LEU B 334
LEU B 293
 None
 1.10A 5hnyB-5l3sB:
undetectable		 5hnyB-5l3sB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 5l3s SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Sulfolobus
acidocaldarius) 		5 / 9 MET B 196
VAL B 193
ILE B 176
TYR B 314
LEU B 334
 None
 1.34A 5iepA-5l3sB:
undetectable		 5iepA-5l3sB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ONL_A_010A302_0
(YNDL)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		4 / 5 GLU A  53
LYS A  57
GLU A  58
GLU A  77
 None
 1.34A 5onlA-5l3sA:
undetectable		 5onlA-5l3sA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 5l3s SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Sulfolobus
acidocaldarius) 		5 / 12 ILE B 150
LEU B 334
PHE B 362
LEU B 120
LEU B 102
 None
 1.24A 5tiwA-5l3sB:
3.6		 5tiwA-5l3sB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		5 / 10 GLY A 255
GLY A 223
LEU A  47
ILE A  35
LEU A  34
 None
 0.91A 5vm8B-5l3sA:
2.2		 5vm8B-5l3sA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		4 / 6 ASN A 162
PRO A 163
ILE A 164
GLU A 204
 None
 1.17A 6h7uA-5l3sA:
undetectable		 6h7uA-5l3sA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HRJ_A_010A302_0
(YNDL)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		4 / 5 GLU A  53
LYS A  57
GLU A  58
GLU A  77
 None
 1.37A 6hrjA-5l3sA:
undetectable		 6hrjA-5l3sA:
22.26