SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l3t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5l3t NUCLEAR MRNA EXPORT
PROTEIN SAC3
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 544
LEU A 532
LEU A 342
LEU A 345
 None
 0.94A 1errA-5l3tA:
undetectable		 1errA-5l3tA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 5l3t NUCLEAR MRNA EXPORT
PROTEIN SAC3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 508
ILE A 498
ILE A 500
PHE A 474
LEU A 477
 None
 1.22A 1xdkB-5l3tA:
undetectable		 1xdkB-5l3tA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5l3t NUCLEAR MRNA EXPORT
PROTEIN SAC3
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 256
ILE A 290
PHE A 282
GLY A 281
LEU A 317
 None
 1.33A 2nyrB-5l3tA:
undetectable		 2nyrB-5l3tA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5l3t NUCLEAR MRNA EXPORT
PROTEIN SAC3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 477
ILE A 490
THR A 510
HIS A 469
THR A 464
 None
 1.12A 4ze2A-5l3tA:
undetectable		 4ze2A-5l3tA:
17.52