SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 4 HIS B 481
LEU B 529
LEU B 497
LEU B 470
 None
 1.25A 1a4lD-5l3xB:
undetectable		 1a4lD-5l3xB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		5 / 12 ALA B 361
LEU B 341
PHE B 337
ILE B 310
LEU B 305
 None
 1.21A 1ddrB-5l3xB:
undetectable		 1ddrB-5l3xB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens;
Homo
sapiens) 		4 / 6 VAL B 247
MET B 244
ILE A  96
ASN A 107
 None
 0.84A 1e06A-5l3xB:
undetectable		 1e06A-5l3xB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 7 GLU B 406
LEU B 407
VAL B 450
LEU B 443
 None
 0.98A 1hk3A-5l3xB:
undetectable		 1hk3A-5l3xB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU B 239
LEU A  61
LEU A  75
PRO A 101
VAL A  68
 None
 1.23A 1hrkA-5l3xB:
undetectable		 1hrkA-5l3xB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		5 / 12 ALA B 361
LEU B 341
PHE B 337
ILE B 310
LEU B 305
 None
 1.16A 1jolA-5l3xB:
undetectable		 1jolA-5l3xB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		5 / 12 ALA B 361
LEU B 341
PHE B 337
ILE B 310
LEU B 305
 None
 1.15A 1jolB-5l3xB:
undetectable		 1jolB-5l3xB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		5 / 11 ALA B 361
LEU B 341
PHE B 337
ILE B 310
LEU B 305
 None
 1.15A 1jomA-5l3xB:
undetectable		 1jomA-5l3xB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 4 LEU B 205
VAL B 231
CYH B 232
ALA B 269
 None
 1.28A 1mz9E-5l3xB:
undetectable		 1mz9E-5l3xB:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		5 / 12 ALA B 361
LEU B 341
PHE B 337
ILE B 310
LEU B 305
 None
 1.17A 1tdrA-5l3xB:
undetectable		 1tdrA-5l3xB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 4 LEU B 529
SER B 528
TYR B 532
LEU B 497
 None
 1.05A 1xz1A-5l3xB:
undetectable		 1xz1A-5l3xB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 4 LEU B 529
SER B 528
TYR B 532
LEU B 497
 None
 1.05A 1xz3A-5l3xB:
undetectable		 1xz3A-5l3xB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 6 LEU B 554
ARG B 531
THR B 535
LEU B 538
 None
 1.06A 2dysN-5l3xB:
2.3
2dysW-5l3xB:
undetectable		 2dysN-5l3xB:
21.91
2dysW-5l3xB:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 7 LEU B 554
ARG B 531
THR B 535
LEU B 538
 None
 1.04A 2eikA-5l3xB:
undetectable
2eikJ-5l3xB:
undetectable		 2eikA-5l3xB:
21.91
2eikJ-5l3xB:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 6 LEU B 554
ARG B 531
THR B 535
LEU B 538
 None
 1.05A 2eilA-5l3xB:
undetectable
2eilJ-5l3xB:
undetectable		 2eilA-5l3xB:
21.91
2eilJ-5l3xB:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens;
Homo
sapiens) 		5 / 11 LEU B 239
LEU A  61
LEU A  75
PRO A 101
VAL A  68
 None
 1.26A 2po5B-5l3xB:
undetectable		 2po5B-5l3xB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU B 239
LEU A  61
LEU A  75
PRO A 101
VAL A  68
 None
 1.25A 2po7B-5l3xB:
undetectable		 2po7B-5l3xB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU B 239
LEU A  61
LEU A  75
PRO A 101
VAL A  68
 None
 1.35A 2qd4A-5l3xB:
undetectable		 2qd4A-5l3xB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU B 239
LEU A  61
LEU A  75
PRO A 101
VAL A  68
 None
 1.26A 2qd4B-5l3xB:
undetectable		 2qd4B-5l3xB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens;
Homo
sapiens) 		5 / 10 LEU B 213
VAL A 128
GLY A 129
GLY B 216
ALA B 257
 None
 0.95A 2v3kA-5l3xB:
undetectable		 2v3kA-5l3xB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		3 / 3 PHE B 578
CYH B 582
PHE B 586
 None
None
CL  B 601 ( 4.8A)
 0.96A 3cr5X-5l3xB:
undetectable		 3cr5X-5l3xB:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		5 / 12 LEU B 283
ALA B 276
HIS B 236
LEU A  97
ALA B 282
 None
 1.14A 3dfrA-5l3xB:
undetectable		 3dfrA-5l3xB:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 5 ASP B 321
ILE B 378
VAL B 325
THR B 285
 None
 1.18A 3eigA-5l3xB:
undetectable		 3eigA-5l3xB:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		5 / 12 ALA B 361
LEU B 341
PHE B 337
ILE B 310
LEU B 305
 None
 1.26A 3ia4C-5l3xB:
undetectable		 3ia4C-5l3xB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 6 MET B 245
TRP A  89
GLN B 242
TYR B 238
 None
 1.44A 3mnoA-5l3xB:
undetectable		 3mnoA-5l3xB:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 6 MET B 245
TRP A  89
GLN B 242
TYR B 238
 None
 1.42A 3mnpA-5l3xB:
undetectable		 3mnpA-5l3xB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 6 MET B 245
TRP A  89
MET A  92
GLN B 242
 None
 1.48A 3mnpA-5l3xB:
undetectable		 3mnpA-5l3xB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens;
Homo
sapiens) 		4 / 5 GLU A  22
LEU A  23
HIS B 274
GLY B 234
 None
 1.18A 3pp1A-5l3xA:
undetectable		 3pp1A-5l3xA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		5 / 12 ALA B 361
LEU B 341
PHE B 337
ILE B 310
LEU B 305
 None
 1.20A 3ql0A-5l3xB:
undetectable		 3ql0A-5l3xB:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 6 ILE B 579
ARG B 531
THR B 535
LEU B 538
 None
 1.05A 3wg7N-5l3xB:
2.3
3wg7W-5l3xB:
undetectable		 3wg7N-5l3xB:
21.91
3wg7W-5l3xB:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 6 PHE B 333
TYR B 356
HIS B 354
VAL B 390
 None
 1.10A 4a97I-5l3xB:
undetectable		 4a97I-5l3xB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 5l3x NEGATIVE ELONGATION
FACTOR A
(Homo
sapiens) 		3 / 3 LYS A   6
THR A   9
ILE A  38
 None
 0.92A 4e0fB-5l3xA:
undetectable		 4e0fB-5l3xA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 6 LEU A  61
LEU B 283
PHE B 227
MET B 230
 None
 0.96A 4o1zA-5l3xA:
undetectable		 4o1zA-5l3xA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		5 / 11 ALA B 361
LEU B 341
PHE B 337
ILE B 310
LEU B 305
 None
 1.20A 4qlfA-5l3xB:
undetectable		 4qlfA-5l3xB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 5 PHE B 553
PHE A 163
PHE B 549
VAL B 537
 None
 0.86A 5a1rA-5l3xB:
undetectable		 5a1rA-5l3xB:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 8 LEU B 281
GLY B 297
ALA B 298
SER B 301
 None
 0.52A 5f1aA-5l3xB:
1.6		 5f1aA-5l3xB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 7 LEU B 281
GLY B 297
ALA B 298
SER B 301
 None
 0.51A 5f1aB-5l3xB:
undetectable		 5f1aB-5l3xB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 6 VAL B 431
HIS B 451
CYH B 397
LEU B 414
 None
 1.18A 5hrqB-5l3xB:
undetectable
5hrqI-5l3xB:
undetectable
5hrqJ-5l3xB:
undetectable		 5hrqB-5l3xB:
6.79
5hrqI-5l3xB:
4.69
5hrqJ-5l3xB:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 6 VAL B 431
HIS B 451
CYH B 397
LEU B 414
 None
 1.17A 5hrqH-5l3xB:
undetectable
5hrqK-5l3xB:
undetectable
5hrqL-5l3xB:
undetectable		 5hrqH-5l3xB:
6.79
5hrqK-5l3xB:
4.69
5hrqL-5l3xB:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 8 GLN B 442
TYR B 440
LEU B 492
LEU B 484
 None
 0.94A 5hs6A-5l3xB:
undetectable		 5hs6A-5l3xB:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 5 ILE B 418
LEU A 178
HIS B 451
VAL B 431
 None
 1.21A 5jmnB-5l3xB:
3.7		 5jmnB-5l3xB:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		5 / 12 PHE B 317
ILE B 359
ALA B 308
VAL B 312
ILE B 310
 None
 1.25A 5mlmA-5l3xB:
undetectable		 5mlmA-5l3xB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens;
Homo
sapiens) 		3 / 3 TYR B 238
SER B 277
TRP A  24
 None
 0.86A 5n8jB-5l3xB:
undetectable		 5n8jB-5l3xB:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens;
Homo
sapiens) 		3 / 3 TYR B 238
SER B 277
TRP A  24
 None
 0.86A 5n8jD-5l3xB:
undetectable		 5n8jD-5l3xB:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		5 / 12 LEU B 313
ILE B 310
PHE B 337
LEU B 336
VAL B 330
 None
 1.34A 5uanB-5l3xB:
undetectable		 5uanB-5l3xB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 7 ASP B 335
ARG B 267
GLU B 271
GLU B 221
 None
 1.24A 6mn5B-5l3xB:
undetectable		 6mn5B-5l3xB:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens) 		4 / 5 LEU B 554
ARG B 531
THR B 535
LEU B 538
 None
 0.91A 6nmpN-5l3xB:
undetectable
6nmpW-5l3xB:
undetectable		 6nmpN-5l3xB:
21.91
6nmpW-5l3xB:
13.27