SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l3z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5l3z POLYKETIDE
KETOREDUCTASE SIMC7
(Streptomyces
antibioticus) 		3 / 3 ARG A 130
ILE A 119
TRP A 126
 None
 1.18A 1m8eB-5l3zA:
undetectable		 1m8eB-5l3zA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5l3z POLYKETIDE
KETOREDUCTASE SIMC7
(Streptomyces
antibioticus) 		3 / 3 ARG A 130
ILE A 119
TRP A 126
 None
 1.17A 1qomA-5l3zA:
undetectable		 1qomA-5l3zA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 5l3z POLYKETIDE
KETOREDUCTASE SIMC7
(Streptomyces
antibioticus) 		4 / 6 PRO A  26
LEU A  20
ARG A  28
GLY A  29
 None
 1.06A 2hs2B-5l3zA:
undetectable		 2hs2B-5l3zA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5l3z POLYKETIDE
KETOREDUCTASE SIMC7
(Streptomyces
antibioticus) 		3 / 3 ARG A 130
ILE A 119
TRP A 126
 None
 1.18A 3e6tB-5l3zA:
undetectable		 3e6tB-5l3zA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5l3z POLYKETIDE
KETOREDUCTASE SIMC7
(Streptomyces
antibioticus) 		3 / 3 ARG A 130
ILE A 119
TRP A 126
 None
 1.06A 3nw2A-5l3zA:
undetectable		 3nw2A-5l3zA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5l3z POLYKETIDE
KETOREDUCTASE SIMC7
(Streptomyces
antibioticus) 		5 / 12 LEU A 188
ALA A 187
ILE A  12
LEU A  93
THR A 161
 None
None
NAP  A 500 (-3.8A)
NAP  A 500 (-4.6A)
None
 0.99A 4psyA-5l3zA:
undetectable		 4psyA-5l3zA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5l3z POLYKETIDE
KETOREDUCTASE SIMC7
(Streptomyces
antibioticus) 		5 / 12 LEU A  68
VAL A 115
ILE A  75
LEU A  60
LEU A  56
 None
 1.30A 4yvpB-5l3zA:
undetectable		 4yvpB-5l3zA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 5l3z POLYKETIDE
KETOREDUCTASE SIMC7
(Streptomyces
antibioticus) 		4 / 4 VAL A  46
GLU A  44
GLY A  29
LEU A   4
 None
 1.17A 5g5gC-5l3zA:
undetectable		 5g5gC-5l3zA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5l3z POLYKETIDE
KETOREDUCTASE SIMC7
(Streptomyces
antibioticus) 		5 / 9 ARG A  32
LEU A  93
ILE A  12
GLY A  13
GLY A   7
 NAP  A 500 (-3.5A)
NAP  A 500 (-4.6A)
NAP  A 500 (-3.8A)
None
NAP  A 500 (-3.5A)
 0.93A 5o96A-5l3zA:
2.6
5o96B-5l3zA:
3.4		 5o96A-5l3zA:
22.86
5o96B-5l3zA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5l3z POLYKETIDE
KETOREDUCTASE SIMC7
(Streptomyces
antibioticus) 		4 / 5 ARG A 215
PRO A 156
GLY A 157
TYR A 155
 None
 0.92A 5x80A-5l3zA:
undetectable
5x80B-5l3zA:
undetectable		 5x80A-5l3zA:
26.71
5x80B-5l3zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5l3z POLYKETIDE
KETOREDUCTASE SIMC7
(Streptomyces
antibioticus) 		4 / 7 ARG A 215
PRO A 156
GLY A 157
TYR A 155
 None
 0.92A 5x80C-5l3zA:
undetectable
5x80D-5l3zA:
undetectable		 5x80C-5l3zA:
26.71
5x80D-5l3zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5l3z POLYKETIDE
KETOREDUCTASE SIMC7
(Streptomyces
antibioticus) 		4 / 5 PRO A 156
GLY A 157
TYR A 155
ARG A 215
 None
 0.91A 5x80C-5l3zA:
undetectable
5x80D-5l3zA:
undetectable		 5x80C-5l3zA:
26.71
5x80D-5l3zA:
26.71