SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l44'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		8 / 12 THR A 460
HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 None
ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.46A 1j36A-5l44A:
19.8		 1j36A-5l44A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		8 / 12 THR A 460
HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 None
ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.46A 1j36B-5l44A:
19.6		 1j36B-5l44A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		7 / 11 HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.48A 1j37A-5l44A:
19.6		 1j37A-5l44A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		7 / 11 HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.47A 1j37B-5l44A:
19.7		 1j37B-5l44A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 456
SER A 202
GLU A 234
GLU A 335
 None
 1.13A 1knyA-5l44A:
3.4
1knyB-5l44A:
3.0		 1knyA-5l44A:
16.22
1knyB-5l44A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 9 GLU A 133
LEU A 137
GLU A  69
ALA A  66
LEU A 429
 None
 1.15A 1mj2A-5l44A:
undetectable		 1mj2A-5l44A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 9 GLU A 133
LEU A 137
GLU A  69
ALA A  66
LEU A 429
 None
 1.18A 1mj2C-5l44A:
undetectable		 1mj2C-5l44A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 11 GLU A 133
LEU A 137
GLU A  69
ALA A  66
LEU A 429
 None
 1.17A 1mjlA-5l44A:
undetectable
1mjlB-5l44A:
undetectable		 1mjlA-5l44A:
9.26
1mjlB-5l44A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 9 GLU A 133
LEU A 137
GLU A  69
ALA A  66
LEU A 429
 None
 1.15A 1mjoA-5l44A:
undetectable		 1mjoA-5l44A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 9 GLU A 133
LEU A 137
GLU A  69
ALA A  66
LEU A 429
 None
 1.16A 1mjoB-5l44A:
undetectable		 1mjoB-5l44A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 9 GLU A 133
LEU A 137
GLU A  69
ALA A  66
LEU A 429
 None
 1.16A 1mjoC-5l44A:
undetectable		 1mjoC-5l44A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		7 / 12 HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.44A 1o86A-5l44A:
6.0		 1o86A-5l44A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.86A 1v7zA-5l44A:
undetectable		 1v7zA-5l44A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.86A 1v7zB-5l44A:
undetectable		 1v7zB-5l44A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.86A 1v7zC-5l44A:
undetectable		 1v7zC-5l44A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.89A 1v7zD-5l44A:
undetectable		 1v7zD-5l44A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.89A 1v7zE-5l44A:
undetectable		 1v7zE-5l44A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.87A 1v7zF-5l44A:
undetectable		 1v7zF-5l44A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		3 / 3 PHE A 591
TYR A 544
TYR A 606
 None
None
SO4  A1004 ( 3.7A)
 0.97A 1x70B-5l44A:
undetectable		 1x70B-5l44A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 11 LEU A 472
LEU A 469
VAL A 437
GLY A 406
ARG A 389
 None
 1.33A 1y4lB-5l44A:
undetectable		 1y4lB-5l44A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 12 ALA A 418
GLU A 464
HIS A 467
GLU A 492
TYR A 599
 None
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
None
 1.27A 2c6nA-5l44A:
19.6		 2c6nA-5l44A:
25.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		8 / 12 ALA A 418
HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 None
ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.40A 2c6nA-5l44A:
19.6		 2c6nA-5l44A:
25.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		7 / 12 HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.44A 2c6nB-5l44A:
17.9		 2c6nB-5l44A:
25.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 THR A 460
HIS A 463
GLU A 464
HIS A 467
 None
ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
 0.23A 2jihB-5l44A:
undetectable		 2jihB-5l44A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 7 VAL A  65
THR A  64
PHE A  61
THR A  60
 None
 1.13A 2kotA-5l44A:
undetectable		 2kotA-5l44A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_H_BEZH2001_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 10 PHE A 364
LEU A 359
GLY A 406
ASN A 438
PHE A 465
 None
 1.31A 2ok6A-5l44A:
1.5
2ok6H-5l44A:
undetectable		 2ok6A-5l44A:
21.61
2ok6H-5l44A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 12 PHE A 591
TRP A 608
SER A 605
TYR A 606
VAL A 491
 None
None
None
SO4  A1004 ( 3.7A)
K26  A1005 (-4.7A)
 1.36A 2rguA-5l44A:
undetectable		 2rguA-5l44A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 6 LEU A 167
LEU A 163
ILE A 263
ARG A 262
 None
 1.11A 2rlfB-5l44A:
undetectable
2rlfC-5l44A:
undetectable		 2rlfB-5l44A:
5.65
2rlfC-5l44A:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		7 / 11 HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.40A 2x8zA-5l44A:
19.8		 2x8zA-5l44A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		7 / 12 HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.42A 2x91A-5l44A:
19.8		 2x91A-5l44A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.85A 3a6jA-5l44A:
undetectable		 3a6jA-5l44A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 7 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.82A 3a6jB-5l44A:
undetectable		 3a6jB-5l44A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.83A 3a6jC-5l44A:
undetectable		 3a6jC-5l44A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.86A 3a6jE-5l44A:
undetectable		 3a6jE-5l44A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.83A 3a6jF-5l44A:
undetectable		 3a6jF-5l44A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 7 GLN A  45
GLY A  72
HIS A 113
HIS A 108
 None
 1.23A 3ai8A-5l44A:
undetectable		 3ai8A-5l44A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 11 LEU A 105
PHE A  13
ALA A  37
MET A  42
PHE A  83
 None
 1.44A 3bszF-5l44A:
undetectable		 3bszF-5l44A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 7 TYR A 282
ARG A 140
HIS A 113
ALA A 148
 None
 1.27A 3frqB-5l44A:
undetectable		 3frqB-5l44A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 7 GLU A 543
TYR A 590
TYR A 586
TYR A 603
 None
None
SO4  A1004 (-4.4A)
SO4  A1004 (-4.8A)
 1.28A 3ku9B-5l44A:
2.4		 3ku9B-5l44A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 7 ASN A  11
ALA A  37
PRO A  36
TYR A  34
 None
 0.94A 3twpA-5l44A:
2.2		 3twpA-5l44A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 7 ASN A  11
ALA A  37
PRO A  36
TYR A  34
 None
 0.93A 3twpB-5l44A:
undetectable		 3twpB-5l44A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 7 ASN A  11
ALA A  37
PRO A  36
TYR A  34
 None
 0.93A 3twpC-5l44A:
undetectable		 3twpC-5l44A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 5 ASN A  11
ALA A  37
PRO A  36
TYR A  34
 None
 0.94A 3twpD-5l44A:
undetectable		 3twpD-5l44A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 9 ILE A  52
ARG A 121
LEU A 118
PRO A 479
SER A 427
 None
 1.26A 3w1wB-5l44A:
undetectable		 3w1wB-5l44A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		7 / 11 HIS A 463
GLU A 464
HIS A 467
GLU A 492
HIS A 593
TYR A 603
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
K26  A1005 ( 3.3A)
SO4  A1004 (-4.8A)
SO4  A1004 ( 3.7A)
 0.54A 4c2pA-5l44A:
17.5		 4c2pA-5l44A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		6 / 11 HIS A 463
GLU A 464
HIS A 467
GLU A 492
TYR A 544
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
None
SO4  A1004 ( 3.7A)
 1.49A 4c2pA-5l44A:
17.5		 4c2pA-5l44A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 5 HIS A 279
GLN A 287
GLY A 602
SER A 600
 None
 1.27A 4fu8A-5l44A:
undetectable		 4fu8A-5l44A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 11 LEU A 195
ARG A 243
VAL A 187
ILE A 188
LEU A 215
 None
 1.34A 4lhmA-5l44A:
2.3		 4lhmA-5l44A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 12 HIS A 463
GLU A 464
HIS A 467
GLU A 492
TYR A 606
 ZN  A1001 ( 3.3A)
K26  A1005 (-2.7A)
ZN  A1001 ( 3.4A)
ZN  A1001 ( 2.2A)
SO4  A1004 ( 3.7A)
 0.46A 4r7lA-5l44A:
7.5		 4r7lA-5l44A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 5 TYR A 590
LEU A 572
PRO A 583
LEU A 565
 None
 1.41A 5eshA-5l44A:
undetectable		 5eshA-5l44A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_C_MMZC503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 4 TYR A  34
ASN A  84
SER A  87
SER A  86
 None
None
K26  A1005 ( 4.2A)
None
 1.23A 5gsnC-5l44A:
1.1		 5gsnC-5l44A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 6 VAL A  49
LEU A 105
ILE A 101
PHE A  38
 None
 1.06A 5jw1A-5l44A:
2.3		 5jw1A-5l44A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 6 PHE A 473
LEU A 638
SER A 474
GLY A 642
 None
 1.00A 5o4yF-5l44A:
undetectable		 5o4yF-5l44A:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		4 / 8 SER A 532
GLN A 533
MET A 529
MET A 349
 None
 1.45A 5wqpA-5l44A:
undetectable		 5wqpA-5l44A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 12 TRP A 136
ASP A 286
ALA A 289
ARG A 140
ASP A 646
 None
 1.30A 6clxA-5l44A:
undetectable		 6clxA-5l44A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE
(Astrosporangium
hypotensionis) 		5 / 9 LEU A 639
SER A 640
PHE A 473
GLU A 475
LEU A 401
 None
 1.25A 6ftpA-5l44A:
undetectable
6ftpB-5l44A:
undetectable		 6ftpA-5l44A:
8.84
6ftpB-5l44A:
5.55