SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l46'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 662
ALA A 671
GLY A 681
LEU A 644
GLN A 642
 None
 1.27A 1brpA-5l46A:
undetectable		 1brpA-5l46A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ILE A 698
LEU A 662
VAL A 669
ILE A 667
 None
 0.89A 1fm6D-5l46A:
undetectable		 1fm6D-5l46A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 604
LEU A 581
MET A 570
TYR A 578
 None
 1.10A 1kt3A-5l46A:
undetectable		 1kt3A-5l46A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASN A 453
ARG A 292
TYR A 399
TYR A 312
 None
 1.36A 1nbhB-5l46A:
0.9		 1nbhB-5l46A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ASN A 453
ARG A 292
TYR A 399
TYR A 312
 None
 1.37A 1nbhC-5l46A:
0.9		 1nbhC-5l46A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASN A 453
ARG A 292
TYR A 399
TYR A 312
 None
 1.37A 1nbhD-5l46A:
0.9		 1nbhD-5l46A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 605
ILE A 607
TRP A 606
 None
 1.19A 1qomA-5l46A:
undetectable		 1qomA-5l46A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A 582
ILE A 567
ILE A 674
TYR A 685
THR A 532
 None
 1.13A 1re7A-5l46A:
undetectable		 1re7A-5l46A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 552
ASP A 753
ASN A 557
 None
 0.81A 2bm9D-5l46A:
2.4		 2bm9D-5l46A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 TYR A 299
TYR A 399
TYR A 374
HIS A 270
 None
None
None
FAD  A 901 (-4.8A)
 1.21A 2bteA-5l46A:
undetectable		 2bteA-5l46A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TYR A 299
TYR A 399
TYR A 374
HIS A 270
 None
None
None
FAD  A 901 (-4.8A)
 1.21A 2bytA-5l46A:
undetectable		 2bytA-5l46A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TYR A 299
TYR A 399
TYR A 374
HIS A 270
 None
None
None
FAD  A 901 (-4.8A)
 1.20A 2bytD-5l46A:
undetectable		 2bytD-5l46A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU A 847
GLU A 721
SER A 812
LEU A 813
ASP A 783
 None
 1.26A 2c12F-5l46A:
undetectable		 2c12F-5l46A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 THR A 468
THR A 436
THR A 437
THR A 438
GLY A 465
 None
 0.93A 2f162-5l46A:
undetectable		 2f162-5l46A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 THR A 468
THR A 436
THR A 437
THR A 438
GLY A 465
 None
 0.94A 2f16N-5l46A:
undetectable		 2f16N-5l46A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ILE A 278
PHE A 173
VAL A 358
ALA A 352
LEU A 300
 None
 0.92A 2m9qA-5l46A:
undetectable		 2m9qA-5l46A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 605
ILE A 607
TRP A 606
 None
 1.09A 2nodB-5l46A:
undetectable		 2nodB-5l46A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 VAL A 612
GLU A 608
GLU A 609
 None
 0.80A 2nv4A-5l46A:
undetectable		 2nv4A-5l46A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 400
GLY A 249
ILE A 395
VAL A 268
ILE A 372
 FAD  A 901 (-3.2A)
FAD  A 901 (-3.4A)
None
None
FAD  A 901 (-4.3A)
 0.96A 2pymB-5l46A:
undetectable		 2pymB-5l46A:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 428
THR A 572
PRO A 573
 None
 0.66A 2q64B-5l46A:
undetectable		 2q64B-5l46A:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_D_LEUD1883_0
(AMINOACYL-TRNA
SYNTHETASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 TYR A 299
TYR A 399
TYR A 374
HIS A 270
 None
None
None
FAD  A 901 (-4.8A)
 1.05A 2v0gD-5l46A:
undetectable		 2v0gD-5l46A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LEU A 551
GLY A 589
GLY A 544
GLN A 545
 None
 0.77A 2wd9B-5l46A:
undetectable		 2wd9B-5l46A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 VAL A 612
ASN A 390
TRP A 392
 None
 0.50A 2y00B-5l46A:
undetectable		 2y00B-5l46A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 THR A 438
PRO A 264
THR A 436
 None
 0.91A 316dC-5l46A:
undetectable		 316dC-5l46A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ILE A 402
HIS A 403
TYR A 116
GLY A 406
 FAD  A 901 (-4.6A)
None
None
None
 1.23A 3b9mA-5l46A:
undetectable		 3b9mA-5l46A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 633
LEU A 680
MET A 526
ARG A 673
SER A 675
 None
 1.22A 3bxoA-5l46A:
2.5		 3bxoA-5l46A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 698
LEU A 478
GLU A 683
SER A 472
PRO A 536
 None
 1.16A 3eigA-5l46A:
undetectable		 3eigA-5l46A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLY A 400
GLY A 249
ILE A 395
VAL A 268
ILE A 372
 FAD  A 901 (-3.2A)
FAD  A 901 (-3.4A)
None
None
FAD  A 901 (-4.3A)
 0.99A 3el1A-5l46A:
undetectable		 3el1A-5l46A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU A 845
VAL A 773
CYH A 774
 None
 1.07A 3fbxA-5l46A:
undetectable		 3fbxA-5l46A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ASP A 231
SER A 238
ASP A  48
ASP A  75
 None
 1.24A 3havA-5l46A:
undetectable		 3havA-5l46A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 678
ILE A 567
PHE A 564
PHE A 656
 None
 0.91A 3ko0B-5l46A:
undetectable
3ko0J-5l46A:
undetectable		 3ko0B-5l46A:
9.00
3ko0J-5l46A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 678
ILE A 567
PHE A 564
PHE A 656
 None
 0.98A 3ko0K-5l46A:
undetectable
3ko0S-5l46A:
undetectable		 3ko0K-5l46A:
9.00
3ko0S-5l46A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A 468
THR A 436
THR A 437
THR A 438
GLY A 465
 None
 0.97A 3mg02-5l46A:
undetectable
3mg0V-5l46A:
undetectable		 3mg02-5l46A:
12.56
3mg0V-5l46A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 THR A 468
THR A 436
THR A 437
THR A 438
GLY A 465
 None
 0.97A 3mg0N-5l46A:
undetectable		 3mg0N-5l46A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 605
ILE A 607
TRP A 606
 None
 1.13A 3nw2B-5l46A:
undetectable		 3nw2B-5l46A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A 100
HIS A 403
ILE A 108
 None
 0.85A 3u52A-5l46A:
undetectable
3u52C-5l46A:
undetectable		 3u52A-5l46A:
20.21
3u52C-5l46A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 THR A 582
ILE A 567
ILE A 674
TYR A 685
THR A 532
 None
 1.14A 3um5B-5l46A:
undetectable		 3um5B-5l46A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ASN A 716
MET A 715
GLY A 485
GLN A 492
 None
 0.98A 4af0A-5l46A:
undetectable		 4af0A-5l46A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP A 251
GLU A 254
VAL A 329
TRP A 324
 FAD  A 901 (-3.9A)
None
None
None
 1.35A 4cwxA-5l46A:
undetectable
4cwxB-5l46A:
undetectable		 4cwxA-5l46A:
20.70
4cwxB-5l46A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 VAL A 329
TRP A 324
TRP A 251
GLU A 254
 None
None
FAD  A 901 (-3.9A)
None
 1.33A 4cwyA-5l46A:
undetectable
4cwyB-5l46A:
undetectable		 4cwyA-5l46A:
20.70
4cwyB-5l46A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP A 251
GLU A 254
VAL A 329
TRP A 324
 FAD  A 901 (-3.9A)
None
None
None
 1.33A 4cwyA-5l46A:
undetectable
4cwyB-5l46A:
undetectable		 4cwyA-5l46A:
20.70
4cwyB-5l46A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 VAL A 773
CYH A 774
LEU A 775
THR A 776
GLU A 824
 None
 1.20A 4e0fA-5l46A:
1.5		 4e0fA-5l46A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 198
TYR A 116
THR A  96
GLY A  94
 None
None
None
FAD  A 901 ( 4.4A)
 0.84A 4eq4A-5l46A:
undetectable		 4eq4A-5l46A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 198
TYR A 116
THR A  96
GLY A  94
 None
None
None
FAD  A 901 ( 4.4A)
 0.84A 4eqlA-5l46A:
undetectable		 4eqlA-5l46A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 198
TYR A 116
THR A  96
GLY A  94
 None
None
None
FAD  A 901 ( 4.4A)
 0.85A 4eqlB-5l46A:
undetectable		 4eqlB-5l46A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU A 198
TYR A 116
THR A  96
GLY A  94
 None
None
None
FAD  A 901 ( 4.4A)
 0.91A 4l39A-5l46A:
undetectable		 4l39A-5l46A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 198
TYR A 116
THR A  96
GLY A  94
 None
None
None
FAD  A 901 ( 4.4A)
 0.88A 4l39B-5l46A:
undetectable		 4l39B-5l46A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 423
TRP A 392
SER A 599
 None
 1.01A 4lrhA-5l46A:
undetectable		 4lrhA-5l46A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 394
LEU A 427
GLY A 400
ALA A 404
TYR A 116
 None
None
FAD  A 901 (-3.2A)
None
None
 1.14A 4pclA-5l46A:
3.2		 4pclA-5l46A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A 582
ILE A 567
ILE A 674
TYR A 685
THR A 532
 None
 1.13A 4ptjA-5l46A:
undetectable		 4ptjA-5l46A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU A 460
ARG A 462
GLN A 150
 None
 0.83A 4rtbA-5l46A:
undetectable		 4rtbA-5l46A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 GLY A  58
GLY A  57
GLY A 249
ALA A 248
ILE A 372
TYR A 399
 FAD  A 901 (-3.3A)
FAD  A 901 (-4.5A)
FAD  A 901 (-3.4A)
FAD  A 901 (-4.1A)
FAD  A 901 (-4.3A)
None
 1.31A 4rtmA-5l46A:
2.4		 4rtmA-5l46A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 PRO A 737
VAL A 746
PHE A 754
GLY A 756
ALA A 759
 None
 1.07A 4zjzA-5l46A:
undetectable		 4zjzA-5l46A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 344
TYR A 449
GLU A 313
 None
 0.66A 4zzbE-5l46A:
undetectable		 4zzbE-5l46A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 TYR A 312
GLY A 398
TYR A 299
GLY A  94
 None
FAD  A 901 (-4.4A)
None
FAD  A 901 ( 4.4A)
 0.97A 5ayfA-5l46A:
undetectable		 5ayfA-5l46A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 VAL A  60
VAL A 407
GLY A 406
PHE A 397
 FAD  A 901 (-3.1A)
None
None
None
 1.09A 5d4nA-5l46A:
3.3
5d4nC-5l46A:
3.4		 5d4nA-5l46A:
8.32
5d4nC-5l46A:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 VAL A 407
VAL A  60
GLY A  61
PHE A 397
 None
FAD  A 901 (-3.1A)
None
None
 1.03A 5d4nA-5l46A:
3.3
5d4nC-5l46A:
3.4		 5d4nA-5l46A:
8.32
5d4nC-5l46A:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 402
HIS A 403
GLY A  94
ILE A 193
GLY A  87
 FAD  A 901 (-4.6A)
None
FAD  A 901 ( 4.4A)
None
FAD  A 901 (-3.2A)
 1.02A 5d4uC-5l46A:
undetectable		 5d4uC-5l46A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 169
LEU A 176
ARG A 136
ASN A 187
GLY A 184
 None
 1.33A 5il1A-5l46A:
undetectable		 5il1A-5l46A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A 584
THR A 565
THR A 659
ILE A 594
 None
 0.91A 5jhdE-5l46A:
undetectable
5jhdG-5l46A:
undetectable		 5jhdE-5l46A:
14.22
5jhdG-5l46A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ARG A 344
GLU A 313
GLY A 310
PRO A 311
 None
 0.74A 5kf8A-5l46A:
undetectable		 5kf8A-5l46A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ARG A 344
GLU A 313
GLY A 310
PRO A 311
 None
 0.84A 5kgpA-5l46A:
undetectable		 5kgpA-5l46A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ARG A 344
GLU A 313
GLY A 310
PRO A 311
 None
 0.86A 5kgpB-5l46A:
undetectable		 5kgpB-5l46A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 631
SER A 675
VAL A 664
ALA A 637
LEU A 641
 None
 1.09A 5kocA-5l46A:
2.2		 5kocA-5l46A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 395
GLY A 249
VAL A 329
TYR A 391
MET A 381
 None
FAD  A 901 (-3.4A)
None
None
None
 1.22A 5n0rA-5l46A:
undetectable		 5n0rA-5l46A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 395
GLY A 249
VAL A 329
TYR A 391
MET A 381
 None
FAD  A 901 (-3.4A)
None
None
None
 1.24A 5n0xB-5l46A:
undetectable		 5n0xB-5l46A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 378
HIS A 100
GLY A 398
GLY A 396
HIS A 403
 None
None
FAD  A 901 (-4.4A)
None
None
 1.03A 5nnaA-5l46A:
undetectable		 5nnaA-5l46A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 378
HIS A 100
GLY A 398
GLY A 396
HIS A 403
 None
None
FAD  A 901 (-4.4A)
None
None
 1.00A 5nnaB-5l46A:
undetectable		 5nnaB-5l46A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 378
HIS A 100
GLY A 398
GLY A 396
HIS A 403
 None
None
FAD  A 901 (-4.4A)
None
None
 1.02A 5nnaC-5l46A:
undetectable		 5nnaC-5l46A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 378
HIS A 100
GLY A 398
GLY A 396
HIS A 403
 None
None
FAD  A 901 (-4.4A)
None
None
 1.03A 5nnaD-5l46A:
undetectable		 5nnaD-5l46A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP A 251
GLU A 254
VAL A 329
TRP A 324
 FAD  A 901 (-3.9A)
None
None
None
 1.49A 5uo9A-5l46A:
0.0
5uo9B-5l46A:
undetectable		 5uo9A-5l46A:
18.71
5uo9B-5l46A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP A 251
GLU A 254
VAL A 329
TRP A 324
 FAD  A 901 (-3.9A)
None
None
None
 1.42A 5uo9C-5l46A:
undetectable
5uo9D-5l46A:
undetectable		 5uo9C-5l46A:
18.71
5uo9D-5l46A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 VAL A 329
TRP A 324
TRP A 251
GLU A 254
 None
None
FAD  A 901 (-3.9A)
None
 1.36A 5vv9A-5l46A:
undetectable
5vv9B-5l46A:
undetectable		 5vv9A-5l46A:
20.70
5vv9B-5l46A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 VAL A 329
TRP A 324
TRP A 251
GLU A 254
 None
None
FAD  A 901 (-3.9A)
None
 1.31A 5vvaA-5l46A:
undetectable
5vvaB-5l46A:
undetectable		 5vvaA-5l46A:
20.70
5vvaB-5l46A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP A 251
GLU A 254
VAL A 329
TRP A 324
 FAD  A 901 (-3.9A)
None
None
None
 1.37A 5vvdA-5l46A:
0.0
5vvdB-5l46A:
undetectable		 5vvdA-5l46A:
18.71
5vvdB-5l46A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP A 251
GLU A 254
VAL A 329
TRP A 324
 FAD  A 901 (-3.9A)
None
None
None
 1.36A 6av6A-5l46A:
undetectable
6av6B-5l46A:
undetectable		 6av6A-5l46A:
6.53
6av6B-5l46A:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 485
HIS A 487
LYS A 498
ASP A 708
CYH A 482
 None
 1.25A 6bxlA-5l46A:
3.5		 6bxlA-5l46A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 487
LYS A 498
ASP A 708
CYH A 482
ASP A 533
 None
 1.35A 6bxlA-5l46A:
3.5		 6bxlA-5l46A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 485
HIS A 487
LYS A 498
CYH A 482
ASP A 533
 None
 1.30A 6bxlB-5l46A:
3.5		 6bxlB-5l46A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP A 251
GLU A 254
VAL A 329
TRP A 324
 FAD  A 901 (-3.9A)
None
None
None
 1.37A 6cieA-5l46A:
undetectable
6cieB-5l46A:
undetectable		 6cieA-5l46A:
6.53
6cieB-5l46A:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A  57
GLY A  56
VAL A 255
ASN A 246
GLY A 249
 FAD  A 901 (-4.5A)
FAD  A 901 (-3.3A)
None
None
FAD  A 901 (-3.4A)
 0.97A 6gneA-5l46A:
3.0		 6gneA-5l46A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A  57
GLY A  56
VAL A 255
ASN A 246
GLY A 249
 FAD  A 901 (-4.5A)
FAD  A 901 (-3.3A)
None
None
FAD  A 901 (-3.4A)
 0.99A 6gneB-5l46A:
undetectable		 6gneB-5l46A:
20.31