SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l5g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5l5g PLEXIN-A2
(Mus
musculus) 		5 / 11 LEU A 198
GLY A 246
GLY A 170
TYR A 243
LEU A 383
 None
 1.16A 1p91A-5l5gA:
undetectable		 1p91A-5l5gA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 6 LYS A 138
LEU A 140
GLU A 150
LEU A 126
 None
 1.17A 1sn5A-5l5gA:
undetectable		 1sn5A-5l5gA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 4 LEU A 371
LEU A 296
SER A 295
LEU A 383
 None
 1.10A 1ya3A-5l5gA:
undetectable		 1ya3A-5l5gA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 7 LEU A 217
PRO A 288
GLY A 180
ASP A 179
 None
 0.90A 2ddwB-5l5gA:
undetectable		 2ddwB-5l5gA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5l5g PLEXIN-A2
(Mus
musculus) 		5 / 12 VAL A 188
ILE A 226
TYR A 243
TYR A 215
SER A 199
 None
 1.36A 2iyfB-5l5gA:
undetectable		 2iyfB-5l5gA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 5l5g PLEXIN-A2
(Mus
musculus) 		5 / 12 PRO A 481
GLY A 449
LEU A 455
ASP A 430
SER A 353
 None
 1.23A 2nv4B-5l5gA:
undetectable		 2nv4B-5l5gA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 7 GLY A 185
THR A 197
MET A 168
SER A 160
 None
 1.24A 2o5yH-5l5gA:
4.9
2o5yL-5l5gA:
5.2		 2o5yH-5l5gA:
11.35
2o5yL-5l5gA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 5l5g PLEXIN-A2
(Mus
musculus) 		5 / 12 THR A 232
LEU A 233
ILE A 241
THR A 167
VAL A 162
 None
 1.16A 3a51B-5l5gA:
undetectable		 3a51B-5l5gA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 5 TYR A 293
ILE A 241
TYR A 243
THR A 167
 None
 1.34A 3dgqA-5l5gA:
undetectable		 3dgqA-5l5gA:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5l5g PLEXIN-A2
(Mus
musculus) 		5 / 12 LEU A  53
TYR A 245
ALA A 436
LEU A 495
ALA A 316
 None
 1.28A 3ou7C-5l5gA:
undetectable		 3ou7C-5l5gA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 8 LEU A 424
ALA A 460
SER A 444
SER A 437
 None
 0.89A 3rodA-5l5gA:
undetectable		 3rodA-5l5gA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 6 LEU A 578
PHE A 596
ALA A 595
LEU A 562
 None
 0.98A 3t3zA-5l5gA:
undetectable		 3t3zA-5l5gA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 6 LEU A 578
PHE A 596
ALA A 595
LEU A 562
 None
 1.00A 3t3zD-5l5gA:
undetectable		 3t3zD-5l5gA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 5l5g PLEXIN-A2
(Mus
musculus) 		3 / 3 LYS A 138
LEU A 140
ALA A 128
 None
 0.60A 4iizA-5l5gA:
undetectable		 4iizA-5l5gA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 8 LYS A 138
LEU A 140
GLU A 150
ALA A 128
 None
 0.82A 4ik6B-5l5gA:
undetectable		 4ik6B-5l5gA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 7 LEU A 159
VAL A 136
PRO A 151
TYR A 215
 None
 0.84A 4lb2A-5l5gA:
0.2		 4lb2A-5l5gA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 7 LEU A 159
VAL A 136
PRO A 151
TYR A 215
 None
 0.96A 4lb2A-5l5gA:
0.2		 4lb2A-5l5gA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5l5g PLEXIN-A2
(Mus
musculus) 		5 / 11 VAL A 188
ILE A 226
TYR A 243
TYR A 215
SER A 199
 None
 1.34A 4m83B-5l5gA:
undetectable		 4m83B-5l5gA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5l5g PLEXIN-A2
(Mus
musculus) 		5 / 11 ALA A 357
GLY A 466
GLY A 467
ALA A 460
SER A 444
 None
 0.97A 4qvlK-5l5gA:
undetectable
4qvlL-5l5gA:
undetectable		 4qvlK-5l5gA:
10.39
4qvlL-5l5gA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5l5g PLEXIN-A2
(Mus
musculus) 		5 / 11 ALA A 357
GLY A 466
GLY A 467
ALA A 460
SER A 444
 None
 0.97A 4qvlY-5l5gA:
undetectable
4qvlZ-5l5gA:
undetectable		 4qvlY-5l5gA:
10.39
4qvlZ-5l5gA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5l5g PLEXIN-A2
(Mus
musculus) 		5 / 10 ALA A 357
GLY A 466
GLY A 467
ALA A 460
SER A 444
 None
 0.95A 4qvmY-5l5gA:
undetectable
4qvmZ-5l5gA:
undetectable		 4qvmY-5l5gA:
10.48
4qvmZ-5l5gA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5l5g PLEXIN-A2
(Mus
musculus) 		5 / 11 ALA A 357
GLY A 466
GLY A 467
ALA A 460
SER A 444
 None
 0.97A 4qw1K-5l5gA:
undetectable
4qw1L-5l5gA:
undetectable		 4qw1K-5l5gA:
10.39
4qw1L-5l5gA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5l5g PLEXIN-A2
(Mus
musculus) 		5 / 12 LEU A 483
SER A 499
LEU A 117
GLY A  65
ALA A  66
 None
 0.97A 4rrwC-5l5gA:
undetectable		 4rrwC-5l5gA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5l5g PLEXIN-A2
(Mus
musculus) 		5 / 12 LEU A 483
SER A 499
LEU A 117
GLY A  65
ALA A  66
 None
 0.97A 4rrzC-5l5gA:
undetectable		 4rrzC-5l5gA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5l5g PLEXIN-A2
(Mus
musculus) 		5 / 11 ALA A 357
GLY A 466
GLY A 467
ALA A 460
SER A 444
 None
 0.96A 5bxnK-5l5gA:
undetectable
5bxnL-5l5gA:
undetectable		 5bxnK-5l5gA:
10.39
5bxnL-5l5gA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5l5g PLEXIN-A2
(Mus
musculus) 		5 / 11 ALA A 357
GLY A 466
GLY A 467
ALA A 460
SER A 444
 None
 0.95A 5bxnY-5l5gA:
undetectable
5bxnZ-5l5gA:
undetectable		 5bxnY-5l5gA:
10.39
5bxnZ-5l5gA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 5l5g PLEXIN-A2
(Mus
musculus) 		3 / 3 ASN A 726
SER A 757
SER A 758
 None
 0.62A 5gsnA-5l5gA:
undetectable		 5gsnA-5l5gA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 4 ASN A  51
SER A  43
ALA A  66
VAL A  70
 None
 1.30A 5nm5A-5l5gA:
undetectable		 5nm5A-5l5gA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 5l5g PLEXIN-A2
(Mus
musculus) 		3 / 3 LYS A 154
HIS A 153
HIS A 157
 None
 1.19A 5oexA-5l5gA:
6.0		 5oexA-5l5gA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 5l5g PLEXIN-A2
(Mus
musculus) 		3 / 3 LYS A 154
HIS A 153
HIS A 157
 None
 1.25A 5oexB-5l5gA:
7.1		 5oexB-5l5gA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 5l5g PLEXIN-A2
(Mus
musculus) 		3 / 3 LYS A 154
HIS A 153
HIS A 157
 None
 1.24A 5oexC-5l5gA:
9.6		 5oexC-5l5gA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 5l5g PLEXIN-A2
(Mus
musculus) 		3 / 3 LYS A 154
HIS A 153
HIS A 157
 None
 1.19A 5oexD-5l5gA:
7.1		 5oexD-5l5gA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 4 VAL A 896
VAL A 930
TYR A 949
GLN A 948
 None
 1.03A 5qgqA-5l5gA:
undetectable		 5qgqA-5l5gA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 4 VAL A 896
VAL A 930
TYR A 949
GLN A 948
 None
 1.08A 5qhbA-5l5gA:
undetectable		 5qhbA-5l5gA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 7 SER A 810
ALA A 911
ILE A 878
LEU A 932
 None
 0.86A 5te8A-5l5gA:
undetectable		 5te8A-5l5gA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 8 ILE A 241
PRO A 263
THR A 262
PRO A 260
 None
 1.05A 5x23A-5l5gA:
undetectable		 5x23A-5l5gA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 5 TYR A  38
VAL A 475
LEU A 455
SER A 510
 None
 1.15A 6a7pA-5l5gA:
undetectable		 6a7pA-5l5gA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 8 ILE A 860
THR A 861
GLN A 859
SER A 810
 None
 1.07A 6c06C-5l5gA:
undetectable		 6c06C-5l5gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 5 SER A 474
VAL A 475
LYS A 454
PRO A 481
 None
 1.35A 6fi4A-5l5gA:
undetectable
6fi4B-5l5gA:
undetectable		 6fi4A-5l5gA:
11.21
6fi4B-5l5gA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5l5g PLEXIN-A2
(Mus
musculus) 		4 / 7 HIS A  56
THR A  59
ARG A 141
ASP A 143
 None
 1.15A 6mn4E-5l5gA:
undetectable		 6mn4E-5l5gA:
11.98