SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5l5n PLEXIN-A4
(Mus
musculus) 		4 / 6 LEU A 279
GLU A 294
TRP A 384
THR A 197
 LEU  A 279 ( 0.5A)
GLU  A 294 ( 0.5A)
TRP  A 384 ( 0.5A)
THR  A 197 ( 0.8A)
 1.29A 1qvuA-5l5nA:
undetectable		 1qvuA-5l5nA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 5l5n PLEXIN-A4
(Mus
musculus) 		4 / 5 ASP A  76
LEU A  77
LYS A  78
ARG A 503
 ASP  A  76 ( 0.5A)
LEU  A  77 ( 0.5A)
LYS  A  78 ( 0.0A)
ARG  A 503 ( 0.6A)
 1.33A 2gj5A-5l5nA:
undetectable		 2gj5A-5l5nA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 5l5n PLEXIN-A4
(Mus
musculus) 		4 / 5 ASP A 429
SER A 451
LEU A 454
GLY A 448
 ASP  A 429 ( 0.5A)
SER  A 451 ( 0.0A)
LEU  A 454 ( 0.5A)
GLY  A 448 ( 0.0A)
 1.11A 2j2pA-5l5nA:
undetectable
2j2pB-5l5nA:
undetectable		 2j2pA-5l5nA:
11.41
2j2pB-5l5nA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5l5n PLEXIN-A4
(Mus
musculus) 		3 / 3 ARG A 365
GLU A 416
GLN A 361
 ARG  A 365 ( 0.6A)
GLU  A 416 ( 0.5A)
GLN  A 361 ( 0.6A)
 0.82A 2p16A-5l5nA:
undetectable		 2p16A-5l5nA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 5l5n PLEXIN-A4
(Mus
musculus) 		5 / 8 GLY A  65
HIS A  52
ILE A  62
MET A 496
ALA A 128
 GLY  A  65 ( 0.0A)
HIS  A  52 ( 1.0A)
ILE  A  62 ( 0.6A)
MET  A 496 ( 0.0A)
ALA  A 128 ( 0.0A)
 1.10A 2x0pA-5l5nA:
undetectable		 2x0pA-5l5nA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l5n PLEXIN-A4
(Mus
musculus) 		4 / 8 GLU A 498
SER A 497
ARG A 430
VAL A 480
 GLU  A 498 ( 0.5A)
SER  A 497 ( 0.0A)
ARG  A 430 ( 0.6A)
VAL  A 480 ( 0.6A)
 1.33A 3jx1A-5l5nA:
undetectable
3jx1B-5l5nA:
undetectable		 3jx1A-5l5nA:
16.53
3jx1B-5l5nA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 5l5n PLEXIN-A4
(Mus
musculus) 		4 / 5 HIS A 490
LEU A 333
LEU A 314
ASP A 331
 HIS  A 490 ( 1.0A)
LEU  A 333 ( 0.5A)
LEU  A 314 ( 0.5A)
ASP  A 331 ( 0.5A)
 1.26A 4aqlA-5l5nA:
undetectable		 4aqlA-5l5nA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5l5n PLEXIN-A4
(Mus
musculus) 		4 / 8 ASN A 792
LEU A 721
ASN A 796
ILE A 709
 ASN  A 792 ( 0.6A)
LEU  A 721 ( 0.6A)
ASN  A 796 ( 0.6A)
ILE  A 709 ( 0.6A)
 0.93A 4k0bA-5l5nA:
undetectable		 4k0bA-5l5nA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 5l5n PLEXIN-A4
(Mus
musculus) 		3 / 3 ARG A  69
GLU A  45
PHE A  42
 ARG  A  69 ( 0.6A)
GLU  A  45 ( 0.5A)
PHE  A  42 ( 1.3A)
 0.78A 4kszA-5l5nA:
undetectable		 4kszA-5l5nA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5l5n PLEXIN-A4
(Mus
musculus) 		4 / 8 ASN A 792
LEU A 721
ASN A 796
ILE A 709
 ASN  A 792 ( 0.6A)
LEU  A 721 ( 0.6A)
ASN  A 796 ( 0.6A)
ILE  A 709 ( 0.6A)
 0.89A 4l7iA-5l5nA:
undetectable		 4l7iA-5l5nA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5l5n PLEXIN-A4
(Mus
musculus) 		3 / 3 LEU A 118
ILE A 127
ARG A 125
 LEU  A 118 ( 0.5A)
ILE  A 127 ( 0.6A)
ARG  A 125 ( 0.6A)
 0.67A 4mk4B-5l5nA:
undetectable		 4mk4B-5l5nA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5l5n PLEXIN-A4
(Mus
musculus) 		4 / 8 GLY A 804
GLU A 808
LEU A 812
LYS A 815
 GLY  A 804 ( 0.0A)
GLU  A 808 ( 0.5A)
LEU  A 812 ( 0.5A)
LYS  A 815 ( 0.0A)
 0.78A 4mwzB-5l5nA:
undetectable		 4mwzB-5l5nA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5l5n PLEXIN-A4
(Mus
musculus) 		3 / 5 GLY A 867
GLY A 871
GLU A 870
 GLY  A 867 ( 0.0A)
GLY  A 871 ( 0.0A)
GLU  A 870 ( 0.6A)
 0.52A 4z2eA-5l5nA:
undetectable
4z2eD-5l5nA:
undetectable		 4z2eA-5l5nA:
18.05
4z2eD-5l5nA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 5l5n PLEXIN-A4
(Mus
musculus) 		3 / 3 ASP A 368
ASN A 363
PHE A 357
 ASP  A 368 ( 0.5A)
ASN  A 363 ( 0.6A)
PHE  A 357 ( 1.3A)
 0.66A 5dsgB-5l5nA:
undetectable		 5dsgB-5l5nA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 5l5n PLEXIN-A4
(Mus
musculus) 		3 / 3 ASN A 725
SER A 756
SER A 757
 ASN  A 725 ( 0.6A)
SER  A 756 ( 0.0A)
SER  A 757 ( 0.0A)
 0.63A 5gsnA-5l5nA:
undetectable		 5gsnA-5l5nA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5l5n PLEXIN-A4
(Mus
musculus) 		4 / 8 LEU A 444
LEU A 493
THR A 471
GLN A 511
 LEU  A 444 ( 0.5A)
LEU  A 493 ( 0.5A)
THR  A 471 ( 0.8A)
GLN  A 511 ( 0.6A)
 1.19A 5hbsA-5l5nA:
undetectable		 5hbsA-5l5nA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5l5n PLEXIN-A4
(Mus
musculus) 		4 / 5 LEU A 382
LEU A 412
MET A 417
GLN A 259
 LEU  A 382 ( 0.5A)
LEU  A 412 ( 0.5A)
MET  A 417 ( 0.0A)
GLN  A 259 ( 0.6A)
 1.46A 5uc3A-5l5nA:
undetectable		 5uc3A-5l5nA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 5l5n PLEXIN-A4
(Mus
musculus) 		3 / 3 THR A 681
THR A 686
ARG A 677
 THR  A 681 ( 0.8A)
THR  A 686 ( 0.8A)
ARG  A 677 ( 0.6A)
 1.03A 5wm2A-5l5nA:
undetectable		 5wm2A-5l5nA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 5l5n PLEXIN-A4
(Mus
musculus) 		5 / 12 GLY A 420
GLY A 298
GLU A 416
VAL A 293
ILE A 366
 GLY  A 420 ( 0.0A)
GLY  A 298 ( 0.0A)
GLU  A 416 ( 0.5A)
VAL  A 293 ( 0.6A)
ILE  A 366 ( 0.6A)
 0.98A 5wz1A-5l5nA:
undetectable		 5wz1A-5l5nA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 5l5n PLEXIN-A4
(Mus
musculus) 		5 / 12 GLY A 420
GLY A 298
GLU A 416
VAL A 293
ILE A 366
 GLY  A 420 ( 0.0A)
GLY  A 298 ( 0.0A)
GLU  A 416 ( 0.5A)
VAL  A 293 ( 0.6A)
ILE  A 366 ( 0.6A)
 1.00A 5wz1C-5l5nA:
undetectable		 5wz1C-5l5nA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 5l5n PLEXIN-A4
(Mus
musculus) 		5 / 12 GLY A 420
GLY A 298
GLU A 416
VAL A 293
ILE A 366
 GLY  A 420 ( 0.0A)
GLY  A 298 ( 0.0A)
GLU  A 416 ( 0.5A)
VAL  A 293 ( 0.6A)
ILE  A 366 ( 0.6A)
 0.97A 5wz1D-5l5nA:
undetectable		 5wz1D-5l5nA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 5l5n PLEXIN-A4
(Mus
musculus) 		5 / 12 GLY A 420
GLY A 298
GLU A 416
VAL A 293
ILE A 366
 GLY  A 420 ( 0.0A)
GLY  A 298 ( 0.0A)
GLU  A 416 ( 0.5A)
VAL  A 293 ( 0.6A)
ILE  A 366 ( 0.6A)
 1.00A 5wz1E-5l5nA:
undetectable		 5wz1E-5l5nA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 5l5n PLEXIN-A4
(Mus
musculus) 		5 / 12 GLY A 420
GLY A 298
GLU A 416
VAL A 293
ILE A 366
 GLY  A 420 ( 0.0A)
GLY  A 298 ( 0.0A)
GLU  A 416 ( 0.5A)
VAL  A 293 ( 0.6A)
ILE  A 366 ( 0.6A)
 0.97A 5wz1F-5l5nA:
undetectable		 5wz1F-5l5nA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 5l5n PLEXIN-A4
(Mus
musculus) 		5 / 12 GLY A 420
GLY A 298
GLU A 416
VAL A 293
ILE A 366
 GLY  A 420 ( 0.0A)
GLY  A 298 ( 0.0A)
GLU  A 416 ( 0.5A)
VAL  A 293 ( 0.6A)
ILE  A 366 ( 0.6A)
 0.97A 5wz1G-5l5nA:
undetectable		 5wz1G-5l5nA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 5l5n PLEXIN-A4
(Mus
musculus) 		5 / 12 GLY A 420
GLY A 298
GLU A 416
VAL A 293
ILE A 366
 GLY  A 420 ( 0.0A)
GLY  A 298 ( 0.0A)
GLU  A 416 ( 0.5A)
VAL  A 293 ( 0.6A)
ILE  A 366 ( 0.6A)
 0.96A 5wz1H-5l5nA:
undetectable		 5wz1H-5l5nA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 5l5n PLEXIN-A4
(Mus
musculus) 		4 / 5 HIS A 630
ASN A 654
VAL A 619
LEU A 597
 HIS  A 630 ( 1.0A)
ASN  A 654 ( 0.6A)
VAL  A 619 ( 0.6A)
LEU  A 597 ( 0.5A)
 1.38A 5xdhD-5l5nA:
undetectable		 5xdhD-5l5nA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5l5n PLEXIN-A4
(Mus
musculus) 		5 / 12 LEU A 203
ARG A 125
ILE A 172
TYR A 245
ILE A 184
 LEU  A 203 ( 0.5A)
ARG  A 125 ( 0.6A)
ILE  A 172 ( 0.7A)
TYR  A 245 ( 1.3A)
ILE  A 184 ( 0.4A)
 1.21A 5y2tB-5l5nA:
undetectable		 5y2tB-5l5nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 5l5n PLEXIN-A4
(Mus
musculus) 		4 / 8 ASN A 409
LEU A 406
LEU A 397
ILE A 399
 ASN  A 409 ( 0.6A)
LEU  A 406 ( 0.5A)
LEU  A 397 ( 0.5A)
ILE  A 399 ( 0.7A)
 0.92A 6cb4A-5l5nA:
undetectable		 6cb4A-5l5nA:
16.75