SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l6f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
5 / 12 ILE A 219
GLY A 100
ALA A  97
GLY A 161
HIS A 166
FAD  A 501 (-4.8A)
FAD  A 501 ( 3.8A)
None
FAD  A 501 (-3.5A)
FAD  A 501 (-4.6A)
0.87A 1nbiA-5l6fA:
undetectable
1nbiA-5l6fA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
5 / 12 ILE A 219
GLY A 100
ALA A  97
GLY A 161
HIS A 166
FAD  A 501 (-4.8A)
FAD  A 501 ( 3.8A)
None
FAD  A 501 (-3.5A)
FAD  A 501 (-4.6A)
0.87A 1nbiB-5l6fA:
undetectable
1nbiB-5l6fA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 7 THR A 119
THR A 128
SER A 222
VAL A  70
None
1.19A 1tv8A-5l6fA:
undetectable
1tv8A-5l6fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 7 THR A 119
THR A 128
SER A 222
VAL A  70
None
1.20A 1tv8B-5l6fA:
undetectable
1tv8B-5l6fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 6 LEU A 473
SER A 215
ILE A 449
HIS A 166
None
FAD  A 501 (-4.1A)
None
FAD  A 501 (-4.6A)
0.90A 1yajF-5l6fA:
undetectable
1yajF-5l6fA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 8 THR A 119
THR A 128
SER A 222
VAL A  70
None
1.17A 2fb2A-5l6fA:
undetectable
2fb2A-5l6fA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 7 THR A 119
THR A 128
SER A 222
VAL A  70
None
1.16A 2fb2B-5l6fA:
undetectable
2fb2B-5l6fA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
5 / 12 ILE A 331
GLY A  92
GLY A 157
PRO A 131
PHE A 223
None
FAD  A 501 (-3.1A)
None
FAD  A 501 ( 4.9A)
None
1.20A 2okcB-5l6fA:
undetectable
2okcB-5l6fA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 6 PHE A 223
PHE A 225
GLY A 167
GLY A 168
None
None
None
FAD  A 501 (-3.5A)
0.86A 2qr2A-5l6fA:
undetectable
2qr2B-5l6fA:
undetectable
2qr2A-5l6fA:
19.08
2qr2B-5l6fA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 5 GLY A 167
GLY A 168
PHE A 223
PHE A 225
None
FAD  A 501 (-3.5A)
None
None
0.82A 2qr2A-5l6fA:
undetectable
2qr2B-5l6fA:
undetectable
2qr2A-5l6fA:
19.08
2qr2B-5l6fA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 7 GLY A 168
GLY A 214
PHE A 223
PHE A 225
FAD  A 501 (-3.5A)
None
None
None
0.82A 2qwxA-5l6fA:
undetectable
2qwxB-5l6fA:
undetectable
2qwxA-5l6fA:
19.24
2qwxB-5l6fA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 8 PHE A 223
PHE A 225
GLY A 167
GLY A 168
None
None
None
FAD  A 501 (-3.5A)
0.81A 2qx4A-5l6fA:
undetectable
2qx4B-5l6fA:
undetectable
2qx4A-5l6fA:
19.08
2qx4B-5l6fA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 6 PHE A 223
PHE A 225
GLY A 167
GLY A 168
None
None
None
FAD  A 501 (-3.5A)
0.83A 2qx6A-5l6fA:
undetectable
2qx6B-5l6fA:
undetectable
2qx6A-5l6fA:
19.08
2qx6B-5l6fA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 6 GLY A 167
GLY A 214
PHE A 223
PHE A 225
None
0.82A 2qx6A-5l6fA:
undetectable
2qx6B-5l6fA:
undetectable
2qx6A-5l6fA:
19.08
2qx6B-5l6fA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 8 LEU A 429
ASP A 424
GLU A 340
SER A 417
None
None
BXP  A 509 ( 4.8A)
None
0.96A 2zw9A-5l6fA:
undetectable
2zw9A-5l6fA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 6 ARG A 272
PRO A 231
GLY A 319
MET A 317
BXP  A 509 (-2.9A)
None
None
None
1.39A 3aqiA-5l6fA:
undetectable
3aqiA-5l6fA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
5 / 12 MET A 381
LEU A 260
GLY A 264
LEU A 304
ILE A 297
None
None
BXP  A 510 (-3.5A)
None
None
1.25A 3h52A-5l6fA:
undetectable
3h52A-5l6fA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
5 / 12 TYR A 488
SER A  95
ILE A 449
GLY A 212
ALA A 213
FAD  A 501 ( 4.4A)
FAD  A 501 (-4.5A)
None
None
None
1.04A 3kk6A-5l6fA:
undetectable
3kk6A-5l6fA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 5 HIS A 174
SER A 387
THR A 390
GLU A 267
None
1.44A 3tm4B-5l6fA:
undetectable
3tm4B-5l6fA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 7 VAL A 371
TYR A 376
LEU A 429
TYR A 421
None
BXP  A 509 (-4.2A)
None
None
1.14A 4b3qA-5l6fA:
undetectable
4b3qA-5l6fA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 5 HIS A 322
GLN A 283
GLY A 284
SER A 236
PEG  A 513 (-4.3A)
PEG  A 513 (-4.4A)
None
None
1.13A 4fu8A-5l6fA:
undetectable
4fu8A-5l6fA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
5 / 12 ASP A 380
TYR A 382
SER A 398
GLY A 162
SER A 173
None
None
None
FAD  A 501 (-3.2A)
None
1.01A 4kn2A-5l6fA:
undetectable
4kn2A-5l6fA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_1
(FOLATE RECEPTOR BETA)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
5 / 12 ASP A 380
TYR A 382
SER A 398
GLY A 162
SER A 173
None
None
None
FAD  A 501 (-3.2A)
None
1.02A 4kn2C-5l6fA:
undetectable
4kn2C-5l6fA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
5 / 11 GLY A 167
GLY A 168
GLY A 214
PHE A 223
PHE A 225
None
FAD  A 501 (-3.5A)
None
None
None
0.97A 4qoiA-5l6fA:
undetectable
4qoiB-5l6fA:
undetectable
4qoiA-5l6fA:
19.24
4qoiB-5l6fA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
3 / 3 ARG A 416
ASP A 415
ARG A 373
None
0.69A 4wq4B-5l6fA:
undetectable
4wq4B-5l6fA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
3 / 3 ASP A 430
LEU A 456
GLY A 455
BXP  A 511 (-4.6A)
None
BXP  A 511 (-3.3A)
0.55A 4xmfA-5l6fA:
undetectable
4xmfA-5l6fA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 5 PHE A 223
PHE A 150
PHE A 225
VAL A 160
None
1.19A 5a1rA-5l6fA:
0.1
5a1rA-5l6fA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
5 / 12 LEU A  78
GLY A  84
ASN A  88
PHE A 486
VAL A 189
None
1.21A 5d0yA-5l6fA:
undetectable
5d0yA-5l6fA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 4 VAL A 109
GLU A 111
GLY A 100
LEU A 101
None
None
FAD  A 501 ( 3.8A)
None
1.19A 5g5gC-5l6fA:
undetectable
5g5gC-5l6fA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 4 THR A 154
LEU A 135
HIS A 163
GLY A 157
BXP  A 509 ( 3.1A)
None
FAD  A 501 (-3.8A)
None
1.46A 5gwyA-5l6fA:
undetectable
5gwyA-5l6fA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
3 / 3 VAL A 348
LEU A 282
MET A 271
None
0.86A 5ikrA-5l6fA:
undetectable
5ikrA-5l6fA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 9 ILE A 297
VAL A 311
THR A 235
ASN A 289
None
None
None
NAG  A 508 (-1.9A)
0.95A 5lg3I-5l6fA:
undetectable
5lg3I-5l6fA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
5 / 12 PHE A 486
ALA A  87
LEU A 165
ILE A  73
LEU A 210
None
None
FAD  A 501 (-4.8A)
None
None
1.09A 5ljeA-5l6fA:
undetectable
5ljeA-5l6fA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 6 GLY A 335
PRO A 334
THR A  48
GLU A  45
None
1.09A 5ny7A-5l6fA:
undetectable
5ny7A-5l6fA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
5 / 11 ARG A 402
GLY A 177
TRP A 182
TYR A 448
LEU A 410
None
None
None
FAD  A 501 (-4.6A)
None
1.49A 5updA-5l6fA:
undetectable
5updA-5l6fA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 6 GLY A 383
THR A 390
TYR A 399
TYR A 382
None
1.19A 6ag0A-5l6fA:
undetectable
6ag0A-5l6fA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
4 / 6 GLY A 383
THR A 390
TYR A 399
TYR A 382
None
1.24A 6ag0C-5l6fA:
undetectable
6ag0C-5l6fA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB7_A_PARA900_0
(AAC(3)-IIIB PROTEIN)
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila)
5 / 10 TYR A 399
ASN A 469
TYR A 382
HIS A 407
GLY A 446
None
1.48A 6mb7A-5l6fA:
undetectable
6mb7A-5l6fA:
11.69