SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l6m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5l6m RIBONUCLEASE VAPC
(Caulobacter
vibrioides) 		5 / 12 ILE B  82
ALA B 100
ALA B  99
GLN B 101
ALA B  75
 None
 1.07A 1fbyA-5l6mB:
undetectable		 1fbyA-5l6mB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5l6m RIBONUCLEASE VAPC
(Caulobacter
vibrioides) 		5 / 12 ILE B  82
ALA B 100
ALA B  99
GLN B 101
ALA B  75
 None
 1.08A 1fbyB-5l6mB:
undetectable		 1fbyB-5l6mB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5l6m RIBONUCLEASE VAPC
(Caulobacter
vibrioides) 		5 / 11 VAL B   9
VAL B 110
TYR B   3
LEU B  66
ILE B  31
 None
None
None
MLI  A 101 (-4.5A)
MLI  A 101 (-4.3A)
 1.36A 1t6zB-5l6mB:
undetectable		 1t6zB-5l6mB:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5l6m RIBONUCLEASE VAPC
(Caulobacter
vibrioides) 		5 / 10 ILE B  82
ALA B 100
ALA B  99
GLN B 101
ALA B  75
 None
 1.09A 2aclC-5l6mB:
undetectable		 2aclC-5l6mB:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5l6m RIBONUCLEASE VAPC
(Caulobacter
vibrioides) 		5 / 11 ILE B  82
ALA B 100
ALA B  99
GLN B 101
ALA B  75
 None
 1.02A 2aclE-5l6mB:
undetectable		 2aclE-5l6mB:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5l6m RIBONUCLEASE VAPC
(Caulobacter
vibrioides) 		3 / 3 ALA B 114
VAL B 110
TRP B 128
 None
 0.88A 2izqA-5l6mB:
undetectable
2izqB-5l6mB:
undetectable		 2izqA-5l6mB:
8.00
2izqB-5l6mB:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5l6m RIBONUCLEASE VAPC
(Caulobacter
vibrioides) 		5 / 12 ILE B  82
ALA B 100
ALA B  99
GLN B 101
ALA B  75
 None
 1.04A 3e00A-5l6mB:
undetectable		 3e00A-5l6mB:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5l6m RIBONUCLEASE VAPC
(Caulobacter
vibrioides) 		5 / 10 ILE B  82
ALA B 100
ALA B  99
GLN B 101
ALA B  75
 None
 1.04A 3falA-5l6mB:
undetectable		 3falA-5l6mB:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_2
(NEURAMINIDASE)		 5l6m RIBONUCLEASE VAPC
VAPB FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 5 LEU A  56
ASP B  15
ARG B  14
ARG B  58
 None
 1.18A 4cpzA-5l6mA:
undetectable		 4cpzA-5l6mA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5l6m RIBONUCLEASE VAPC
(Caulobacter
vibrioides) 		5 / 12 ILE B  82
ALA B 100
ALA B  99
GLN B 101
ALA B  75
 None
 0.92A 4nqaH-5l6mB:
undetectable		 4nqaH-5l6mB:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5l6m RIBONUCLEASE VAPC
VAPB FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 5 ILE B  31
LEU A  56
HIS B  12
VAL B   9
 MLI  A 101 (-4.3A)
None
None
None
 1.20A 5jmnB-5l6mB:
undetectable		 5jmnB-5l6mB:
8.92