SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l6q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  59
VAL A  17
GLU A  81
 None
None
None
ZN  A 203 (-2.5A)
 1.25A 1zzrA-5l6qA:
undetectable
1zzrB-5l6qA:
undetectable		 1zzrA-5l6qA:
15.06
1zzrB-5l6qA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  59
VAL A  17
GLU A  81
 None
None
None
ZN  A 203 (-2.5A)
 1.25A 1zzuA-5l6qA:
undetectable
1zzuB-5l6qA:
undetectable		 1zzuA-5l6qA:
15.06
1zzuB-5l6qA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 GLU A  81
VAL A 106
ARG A  59
VAL A  17
 ZN  A 203 (-2.5A)
None
None
None
 1.25A 1zzuA-5l6qA:
undetectable
1zzuB-5l6qA:
undetectable		 1zzuA-5l6qA:
15.06
1zzuB-5l6qA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  59
VAL A  17
GLU A  81
 None
None
None
ZN  A 203 (-2.5A)
 1.20A 3jx2A-5l6qA:
undetectable
3jx2B-5l6qA:
undetectable		 3jx2A-5l6qA:
14.99
3jx2B-5l6qA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 GLU A  81
VAL A 106
ARG A  59
VAL A  17
 ZN  A 203 (-2.5A)
None
None
None
 1.26A 3jx2A-5l6qA:
undetectable
3jx2B-5l6qA:
undetectable		 3jx2A-5l6qA:
14.99
3jx2B-5l6qA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  59
VAL A  17
GLU A  81
 None
None
None
ZN  A 203 (-2.5A)
 1.25A 3jx3A-5l6qA:
undetectable
3jx3B-5l6qA:
undetectable		 3jx3A-5l6qA:
14.99
3jx3B-5l6qA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 GLU A  81
VAL A 106
ARG A  59
VAL A  17
 ZN  A 203 (-2.5A)
None
None
None
 1.23A 3jx3A-5l6qA:
undetectable
3jx3B-5l6qA:
undetectable		 3jx3A-5l6qA:
14.99
3jx3B-5l6qA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  59
VAL A  17
GLU A  81
 None
None
None
ZN  A 203 (-2.5A)
 1.23A 3jx5A-5l6qA:
undetectable
3jx5B-5l6qA:
undetectable		 3jx5A-5l6qA:
14.99
3jx5B-5l6qA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  59
VAL A  17
GLU A  81
 None
None
None
ZN  A 203 (-2.5A)
 1.19A 3jx6A-5l6qA:
undetectable
3jx6B-5l6qA:
undetectable		 3jx6A-5l6qA:
15.01
3jx6B-5l6qA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5l6q H5AL
(Homo
sapiens) 		5 / 12 PHE A  60
ILE A  73
GLY A  75
ALA A  76
LEU A  13
 None
 1.21A 3n8xA-5l6qA:
undetectable		 3n8xA-5l6qA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5l6q H5AL
(Homo
sapiens) 		5 / 12 PHE A  60
ILE A  73
GLY A  75
ALA A  76
LEU A  13
 None
 1.11A 3n8xB-5l6qA:
undetectable		 3n8xB-5l6qA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  59
VAL A  17
GLU A  81
 None
None
None
ZN  A 203 (-2.5A)
 1.20A 3nljA-5l6qA:
undetectable
3nljB-5l6qA:
undetectable		 3nljA-5l6qA:
15.01
3nljB-5l6qA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  59
VAL A  17
GLU A  81
 None
None
None
ZN  A 203 (-2.5A)
 1.21A 3nlpA-5l6qA:
undetectable
3nlpB-5l6qA:
undetectable		 3nlpA-5l6qA:
14.99
3nlpB-5l6qA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 GLU A  81
VAL A 106
ARG A  59
VAL A  17
 ZN  A 203 (-2.5A)
None
None
None
 1.27A 3nlpA-5l6qA:
undetectable
3nlpB-5l6qA:
undetectable		 3nlpA-5l6qA:
14.99
3nlpB-5l6qA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 8 VAL A 106
ARG A  59
VAL A  17
GLU A  81
 None
None
None
ZN  A 203 (-2.5A)
 1.19A 3nlqA-5l6qA:
undetectable
3nlqB-5l6qA:
undetectable		 3nlqA-5l6qA:
14.99
3nlqB-5l6qA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  59
VAL A  17
GLU A  81
 None
None
None
ZN  A 203 (-2.5A)
 1.22A 3nlrA-5l6qA:
undetectable
3nlrB-5l6qA:
undetectable		 3nlrA-5l6qA:
14.99
3nlrB-5l6qA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  59
VAL A  17
GLU A  81
 None
None
None
ZN  A 203 (-2.5A)
 1.26A 4cx3A-5l6qA:
undetectable
4cx3B-5l6qA:
undetectable		 4cx3A-5l6qA:
14.99
4cx3B-5l6qA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 GLU A  81
VAL A 106
ARG A  59
VAL A  17
 ZN  A 203 (-2.5A)
None
None
None
 1.25A 4cx3A-5l6qA:
undetectable
4cx3B-5l6qA:
undetectable		 4cx3A-5l6qA:
14.99
4cx3B-5l6qA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  59
VAL A  17
GLU A  81
 None
None
None
ZN  A 203 (-2.5A)
 1.26A 4cx4A-5l6qA:
undetectable
4cx4B-5l6qA:
undetectable		 4cx4A-5l6qA:
14.99
4cx4B-5l6qA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 GLU A  81
VAL A 106
ARG A  59
VAL A  17
 ZN  A 203 (-2.5A)
None
None
None
 1.26A 4cx4A-5l6qA:
undetectable
4cx4B-5l6qA:
undetectable		 4cx4A-5l6qA:
14.99
4cx4B-5l6qA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 SER A  88
TYR A  29
ARG A  89
VAL A  97
 None
 1.22A 4l64A-5l6qA:
undetectable		 4l64A-5l6qA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 GLU A  81
VAL A 106
ARG A  59
VAL A  17
 ZN  A 203 (-2.5A)
None
None
None
 1.23A 5addA-5l6qA:
undetectable
5addB-5l6qA:
undetectable		 5addA-5l6qA:
14.99
5addB-5l6qA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5l6q H5AL
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  59
VAL A  17
GLU A  81
 None
None
None
ZN  A 203 (-2.5A)
 1.26A 5g0pA-5l6qA:
undetectable
5g0pB-5l6qA:
undetectable		 5g0pA-5l6qA:
14.99
5g0pB-5l6qA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 5l6q H5AL
(Homo
sapiens) 		4 / 5 ARG A  18
SER A  70
SER A  63
SER A  61
 None
 1.47A 5hswA-5l6qA:
undetectable		 5hswA-5l6qA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 5l6q H5AL
(Homo
sapiens) 		3 / 3 LYS A  49
TRP A  33
SER A  30
 None
 1.06A 5nwwA-5l6qA:
undetectable		 5nwwA-5l6qA:
17.57