SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l6s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 5 LEU A 422
VAL A 417
ALA A 365
CYH A 382
 None
 1.10A 1mz9D-5l6sA:
undetectable		 1mz9D-5l6sA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 4 ILE A 414
ASP A 363
LEU A 367
ARG A 409
 None
 1.23A 2a7qA-5l6sA:
undetectable		 2a7qA-5l6sA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTU_A_BCZA801_0
(NEURAMINIDASE)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLU A 311
LEU A 313
ARG A 353
SER A 312
TYR A 309
 None
 1.35A 2htuA-5l6sA:
undetectable		 2htuA-5l6sA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 11 LEU A  25
ASP A 100
ILE A 127
ALA A 120
ILE A  72
 None
 1.08A 2idwA-5l6sA:
undetectable		 2idwA-5l6sA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 9 ILE A 245
ALA A 166
VAL A 165
CYH A 163
 None
 1.07A 2vufB-5l6sA:
undetectable		 2vufB-5l6sA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVO_A_PAUA314_0
(PANTOTHENATE KINASE)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 11 ASP A 289
LEU A 297
TYR A 273
PHE A 351
ILE A  53
 None
 1.44A 3avoA-5l6sA:
undetectable		 3avoA-5l6sA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 9 LEU A 139
VAL A  71
ILE A  84
ILE A  62
ILE A  24
 None
 1.05A 3ekqB-5l6sA:
undetectable		 3ekqB-5l6sA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 9 LEU A 139
VAL A  71
ILE A  84
ALA A  22
ILE A  24
 None
 0.86A 3el0B-5l6sA:
undetectable		 3el0B-5l6sA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 6 LEU A 350
ILE A 362
CYH A 360
PHE A 359
 None
 0.99A 3ko0S-5l6sA:
undetectable		 3ko0S-5l6sA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A  80
ILE A  24
ILE A  84
PHE A  98
TYR A 131
 None
 1.31A 4a79A-5l6sA:
undetectable		 4a79A-5l6sA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A  80
ILE A  24
ILE A  84
PHE A  98
TYR A 131
 None
 1.31A 4a79B-5l6sA:
undetectable		 4a79B-5l6sA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 11 LEU A  80
ILE A  24
ILE A  84
PHE A  98
TYR A 131
 None
 1.30A 4a7aA-5l6sA:
undetectable		 4a7aA-5l6sA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLU A 311
LEU A 313
ARG A 353
SER A 312
TYR A 309
 None
 1.48A 4mx0A-5l6sA:
undetectable		 4mx0A-5l6sA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 PHE A 240
ASP A 276
GLU A 174
ALA A 175
ALA A 211
 None
 1.17A 4pclA-5l6sA:
2.9		 4pclA-5l6sA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 10 VAL A 383
VAL A  45
LEU A  36
GLY A  48
LEU A 368
 None
 1.12A 4ph9A-5l6sA:
undetectable		 4ph9A-5l6sA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 10 VAL A 383
VAL A  45
LEU A  36
GLY A  48
LEU A 368
 None
 1.11A 4ph9B-5l6sA:
undetectable		 4ph9B-5l6sA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 5 SER A 352
GLY A 336
ARG A 353
GLU A 311
 None
 0.87A 4r82A-5l6sA:
undetectable
4r82B-5l6sA:
undetectable		 4r82A-5l6sA:
18.16
4r82B-5l6sA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ILE A  62
GLY A  65
CYH A  61
GLU A  97
VAL A  99
 None
 1.22A 5hw4A-5l6sA:
undetectable		 5hw4A-5l6sA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 11 ILE A  62
GLY A  65
CYH A  61
GLU A  97
VAL A  99
 None
 1.25A 5hw4B-5l6sA:
undetectable		 5hw4B-5l6sA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ILE A  62
GLY A  65
CYH A  61
GLU A  97
VAL A  99
 None
 1.22A 5hw4C-5l6sA:
undetectable		 5hw4C-5l6sA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 11 ILE A 390
ILE A 396
VAL A 373
ILE A 362
ALA A 365
 None
 1.11A 5lg3A-5l6sA:
undetectable		 5lg3A-5l6sA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 10 ILE A 215
ALA A 140
ILE A  24
ALA A  22
ILE A  66
 None
 0.94A 5mvmD-5l6sA:
undetectable
5mvmE-5l6sA:
undetectable		 5mvmD-5l6sA:
12.02
5mvmE-5l6sA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 TYR A 131
PHE A  91
ALA A 220
LEU A  23
ILE A  24
 None
 1.23A 6aybA-5l6sA:
undetectable		 6aybA-5l6sA:
21.85