SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l73'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 5l73 NEUROPILIN-1
(Homo
sapiens) 		5 / 12 ILE A 793
GLY A 792
GLY A 791
ILE A 683
GLU A 784
 None
 1.03A 1nv8B-5l73A:
undetectable		 1nv8B-5l73A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 5l73 NEUROPILIN-1
(Homo
sapiens) 		5 / 12 ILE A 793
GLY A 792
GLY A 791
ILE A 683
GLU A 784
 None
 1.04A 1sg9B-5l73A:
undetectable		 1sg9B-5l73A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5l73 NEUROPILIN-1
(Homo
sapiens) 		5 / 12 ILE A 793
GLY A 792
GLY A 791
ILE A 683
GLU A 784
 None
 0.93A 1vq1B-5l73A:
undetectable		 1vq1B-5l73A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5l73 NEUROPILIN-1
(Homo
sapiens) 		4 / 6 TRP A 763
GLY A 791
GLY A 681
PHE A 692
 BCN  A 903 (-3.5A)
None
None
None
 0.81A 2qx6A-5l73A:
undetectable
2qx6B-5l73A:
undetectable		 2qx6A-5l73A:
22.08
2qx6B-5l73A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5l73 NEUROPILIN-1
(Homo
sapiens) 		5 / 12 PRO A 682
LEU A 676
GLN A 696
ILE A 683
TYR A 694
 None
 1.38A 4a79A-5l73A:
undetectable		 4a79A-5l73A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5l73 NEUROPILIN-1
(Homo
sapiens) 		5 / 12 PRO A 682
LEU A 676
GLN A 696
ILE A 683
TYR A 694
 None
 1.38A 4a79B-5l73A:
undetectable		 4a79B-5l73A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 5l73 NEUROPILIN-1
(Homo
sapiens) 		5 / 11 ALA A 719
LEU A 770
VAL A 713
LEU A 740
TYR A 742
 None
 1.15A 4g1bB-5l73A:
undetectable		 4g1bB-5l73A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5l73 NEUROPILIN-1
(Homo
sapiens) 		4 / 7 ILE A 798
PHE A 781
ARG A 767
LEU A 770
 None
 0.94A 5iy5N-5l73A:
undetectable
5iy5W-5l73A:
undetectable		 5iy5N-5l73A:
14.03
5iy5W-5l73A:
13.07