SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5l75 FIG000988: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		4 / 4 THR F  75
LEU F  72
VAL F 284
LEU F 281
 None
 0.93A 1fbmB-5l75F:
undetectable		 1fbmB-5l75F:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB
(Klebsiella
pneumoniae) 		5 / 11 SER A  23
ILE A 192
VAL A  32
ALA A 207
ILE A 209
 None
None
PT  A 301 (-4.9A)
None
None
 1.20A 1uduA-5l75A:
undetectable		 1uduA-5l75A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5l75 FIG000988: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		3 / 3 GLU F  10
THR F  75
LEU F 105
 None
 0.68A 1v8bC-5l75F:
undetectable		 1v8bC-5l75F:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 5l75 FIG000906: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		5 / 12 GLY G  75
ALA G  76
ILE G 296
GLY G  81
ILE G  15
 None
 1.01A 2avsB-5l75G:
undetectable		 2avsB-5l75G:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5l75 FIG000988: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		4 / 6 ARG F 126
GLU F  58
ASN F 116
PRO F  57
 None
 1.26A 2ejfB-5l75F:
undetectable		 2ejfB-5l75F:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB
(Klebsiella
pneumoniae) 		4 / 7 ILE A 105
ARG A 106
PRO A  84
GLY A  81
 None
 1.24A 2pnjB-5l75A:
undetectable		 2pnjB-5l75A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5l75 FIG000906: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		3 / 3 LEU G  78
MET G  82
MET G 107
 None
PT  G 401 ( 4.9A)
None
 1.03A 2vavF-5l75G:
undetectable		 2vavF-5l75G:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5l75 FIG000988: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		3 / 3 LEU F  70
MET F  74
MET F 103
 None
 1.00A 2vavF-5l75F:
undetectable		 2vavF-5l75F:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YHD_A_TESA1920_1
(ANDROGEN RECEPTOR)		 5l75 FIG000906: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		5 / 12 LEU G  74
GLY G  81
GLN G  85
MET G  25
THR G  18
 None
None
PT  G 401 (-3.9A)
None
None
 1.35A 2yhdA-5l75G:
undetectable		 2yhdA-5l75G:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5l75 FIG000906: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		4 / 6 ILE G 279
ILE G 111
LEU G 342
PHE G 280
 None
 1.04A 3adsA-5l75G:
undetectable		 3adsA-5l75G:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 5l75 FIG000906: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		4 / 8 MET G  70
ALA G  71
LEU G  74
ILE G  32
 None
 0.78A 3cldB-5l75G:
undetectable		 3cldB-5l75G:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB
(Klebsiella
pneumoniae) 		4 / 4 ILE A 180
ARG A 143
ILE A 179
THR A 200
 None
 1.13A 3ia4C-5l75A:
2.0		 3ia4C-5l75A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5l75 FIG000906: PREDICTED
PERMEASE
FIG000988: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		4 / 8 LEU G 329
THR F  45
VAL F  48
LEU F  49
 None
 0.90A 3uniB-5l75G:
undetectable		 3uniB-5l75G:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB
(Klebsiella
pneumoniae) 		4 / 6 SER A 133
ASP A 132
SER A  94
ASP A  97
 None
 1.26A 4eysA-5l75A:
undetectable		 4eysA-5l75A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5l75 FIG000906: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		5 / 10 PHE G 319
ALA G  72
LEU G  73
GLY G 316
ALA G 360
 None
 1.11A 4fe1A-5l75G:
undetectable
4fe1J-5l75G:
undetectable		 4fe1A-5l75G:
19.87
4fe1J-5l75G:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5l75 FIG000988: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		5 / 12 MET F  88
LEU F  93
ILE F   3
ILE F   4
LEU F  98
 None
 0.84A 4j24A-5l75F:
undetectable		 4j24A-5l75F:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5l75 FIG000988: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		5 / 12 MET F  88
LEU F  93
ILE F   3
ILE F   4
LEU F  98
 None
 0.83A 4j24B-5l75F:
undetectable		 4j24B-5l75F:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 5l75 FIG000906: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		5 / 12 GLY G  79
GLY G  75
ILE G 296
ALA G 292
ALA G  84
 None
 1.17A 4kicA-5l75G:
undetectable		 4kicA-5l75G:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB
(Klebsiella
pneumoniae) 		5 / 12 PHE A 165
GLY A  33
ARG A 206
CYH A 204
ILE A 180
 None
 0.79A 4krhA-5l75A:
2.5		 4krhA-5l75A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB
(Klebsiella
pneumoniae) 		5 / 12 PHE A 165
GLY A  33
ARG A 206
CYH A 204
ILE A 180
 None
 0.76A 4krhB-5l75A:
2.6		 4krhB-5l75A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)		 5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB
(Klebsiella
pneumoniae) 		5 / 12 VAL A 146
ILE A  89
ARG A 143
SER A  88
VAL A 102
 None
 1.45A 4rujA-5l75A:
undetectable		 4rujA-5l75A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB
(Klebsiella
pneumoniae) 		3 / 3 THR A   3
ASN A  27
SER A  28
 None
 0.77A 4tvtA-5l75A:
undetectable		 4tvtA-5l75A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5l75 FIG000906: PREDICTED
PERMEASE
LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB
(Klebsiella
pneumoniae) 		4 / 6 GLU G  88
TYR G  10
LEU G   7
PHE A  90
 None
 1.25A 4twdF-5l75G:
undetectable
4twdG-5l75G:
2.0		 4twdF-5l75G:
22.49
4twdG-5l75G:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5l75 FIG000906: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		4 / 8 PHE G 319
ALA G  72
LEU G  73
GLY G 316
 None
 0.81A 4xk8a-5l75G:
2.0		 4xk8a-5l75G:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB
(Klebsiella
pneumoniae) 		5 / 11 VAL A 197
ASP A 194
THR A 193
TYR A 234
LEU A 235
 None
 1.23A 5jh7D-5l75A:
undetectable		 5jh7D-5l75A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB
FIG000906: PREDICTED
PERMEASE
(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		5 / 12 VAL G  91
SER A 139
LEU A 138
VAL A 146
LEU A 130
 None
 1.17A 5ubbA-5l75G:
undetectable		 5ubbA-5l75G:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5l75 FIG000988: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		4 / 5 LEU F 300
ALA F 302
LEU F 305
LEU F  73
 None
 0.84A 5vkqA-5l75F:
2.4
5vkqD-5l75F:
2.4		 5vkqA-5l75F:
12.66
5vkqD-5l75F:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5l75 FIG000988: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		4 / 5 LEU F  73
LEU F 300
ALA F 302
LEU F 305
 None
 0.86A 5vkqA-5l75F:
2.4
5vkqB-5l75F:
2.4		 5vkqA-5l75F:
12.66
5vkqB-5l75F:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5l75 FIG000988: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		4 / 5 LEU F  73
LEU F 300
ALA F 302
LEU F 305
 None
 0.82A 5vkqB-5l75F:
2.4
5vkqC-5l75F:
2.4		 5vkqB-5l75F:
12.66
5vkqC-5l75F:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5l75 FIG000988: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		4 / 5 LEU F  73
LEU F 300
ALA F 302
LEU F 305
 None
 0.88A 5vkqC-5l75F:
2.4
5vkqD-5l75F:
2.4		 5vkqC-5l75F:
12.66
5vkqD-5l75F:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 5l75 FIG000906: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		5 / 12 MET G 288
ALA G  72
LEU G 293
ILE G 296
ARG G 308
 None
 1.40A 5vlmE-5l75G:
undetectable		 5vlmE-5l75G:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB
(Klebsiella
pneumoniae) 		5 / 12 LEU A 121
ASN A 155
ILE A 148
ALA A 149
ILE A 159
 None
 1.00A 5xiwD-5l75A:
undetectable		 5xiwD-5l75A:
16.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB
(Klebsiella
pneumoniae) 		8 / 10 LEU A  72
ALA A  76
TYR A  82
PRO A  84
SER A  88
PHE A  90
VAL A 102
ARG A 150
 None
 1.09A 6b89A-5l75A:
32.2		 6b89A-5l75A:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB
(Klebsiella
pneumoniae) 		4 / 6 PHE A  90
ARG A  92
LEU A  93
ALA A 101
 None
 0.73A 6b89B-5l75A:
31.0		 6b89B-5l75A:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB
(Klebsiella
pneumoniae) 		8 / 10 LEU A  72
ALA A  76
TYR A  82
PRO A  84
SER A  88
PHE A  90
VAL A 102
ARG A 150
 None
 1.05A 6b89B-5l75A:
31.0		 6b89B-5l75A:
98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5l75 FIG000906: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		4 / 6 SER G 277
ASP G 247
GLN G  65
THR G 330
 None
 1.36A 6djzA-5l75G:
undetectable		 6djzA-5l75G:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 5l75 FIG000906: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		3 / 3 SER G 294
SER G 352
ALA G 286
 None
 0.62A 6dwnC-5l75G:
undetectable		 6dwnC-5l75G:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 5l75 FIG000988: PREDICTED
PERMEASE
(Klebsiella
pneumoniae) 		4 / 7 ILE F  21
LEU F  22
LEU F  73
MET F  74
 None
 0.71A 6g9bA-5l75F:
undetectable
6g9bB-5l75F:
undetectable		 6g9bA-5l75F:
13.80
6g9bB-5l75F:
11.85