SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l7d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		4 / 7 ASP A 209
ARG A 485
VAL A 488
TYR A 207
 None
 1.08A 2yfbA-5l7dA:
5.8		 2yfbA-5l7dA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ASP A 209
ARG A 485
VAL A 488
TYR A 207
 None
 1.09A 2yfbB-5l7dA:
undetectable		 2yfbB-5l7dA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		4 / 4 LEU A 125
PRO A 124
LEU A 146
ARG A 144
 None
 1.22A 3hcoA-5l7dA:
undetectable		 3hcoA-5l7dA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		4 / 7 TYR A 130
VAL A 129
PHE A 166
ILE A 122
 None
 0.97A 3zjqA-5l7dA:
undetectable		 3zjqA-5l7dA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		4 / 7 TYR A 130
VAL A 129
PHE A 166
ILE A 122
 None
 0.98A 3zjqB-5l7dA:
undetectable		 3zjqB-5l7dA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		4 / 8 GLY A 299
GLY A 214
ILE A 215
LEU A 197
 None
 0.83A 4mwzB-5l7dA:
undetectable		 4mwzB-5l7dA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		4 / 6 TYR A 322
LEU A 325
HIS A 470
THR A 466
 None
 1.17A 4paeA-5l7dA:
undetectable		 4paeA-5l7dA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 146
VAL A 182
PRO A 124
TRP A 119
GLY A 111
 None
None
None
None
CLR  A1203 (-4.0A)
 1.31A 4q15A-5l7dA:
undetectable		 4q15A-5l7dA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA A 236
ALA A 524
MET A 525
GLY A 527
PHE A 526
 None
 1.28A 4r29B-5l7dA:
1.1		 4r29B-5l7dA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA A 236
ALA A 524
MET A 525
GLY A 527
PHE A 526
 None
 1.26A 4r29C-5l7dA:
3.1		 4r29C-5l7dA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		5 / 12 SER A  96
ASP A  95
ASP A 172
SER A  89
ARG A 173
 None
CLR  A1203 (-3.7A)
None
None
None
 1.15A 4uroB-5l7dA:
undetectable		 4uroB-5l7dA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		4 / 7 PHE A 268
SER A 259
ALA A 250
LEU A 249
 None
 1.08A 4xk8A-5l7dA:
2.8		 4xk8A-5l7dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		5 / 9 PHE A 460
ALA A 459
PHE A 462
LEU A 412
VAL A 411
 None
 1.49A 4z69A-5l7dA:
undetectable		 4z69A-5l7dA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		10 / 12 ASN A 219
TRP A 281
ASP A 384
SER A 387
TYR A 394
ARG A 400
GLN A 477
GLU A 518
ASN A 521
LEU A 522
 None
 0.68A 5l7iA-5l7dA:
45.1		 5l7iA-5l7dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		8 / 12 ASN A 219
TRP A 281
ASP A 384
SER A 387
TYR A 394
GLN A 477
LEU A 522
MET A 525
 None
 0.86A 5l7iA-5l7dA:
45.1		 5l7iA-5l7dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		5 / 12 GLN A 477
PHE A 484
GLU A 518
ASN A 521
LEU A 522
 None
 0.78A 5l7iA-5l7dA:
45.1		 5l7iA-5l7dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_B_VISB1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		11 / 12 TRP A 281
ASP A 384
SER A 387
TYR A 394
ARG A 400
ASP A 473
GLN A 477
PRO A 513
GLU A 518
ASN A 521
LEU A 522
 None
 0.53A 5l7iB-5l7dA:
40.3		 5l7iB-5l7dA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_B_VISB1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		8 / 12 TRP A 281
ASP A 384
SER A 387
TYR A 394
ASP A 473
PRO A 513
LEU A 522
MET A 525
 None
 0.68A 5l7iB-5l7dA:
40.3		 5l7iB-5l7dA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 146
VAL A 182
PRO A 124
TRP A 119
GLY A 111
 None
None
None
None
CLR  A1203 (-4.0A)
 1.26A 5xipC-5l7dA:
undetectable		 5xipC-5l7dA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ALA A1050
LEU A1053
PHE A1080
ILE A1117
LEU A1025
 None
 1.42A 6h1lA-5l7dA:
undetectable		 6h1lA-5l7dA:
21.43