SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5l7k PROTEIN UNC-119
HOMOLOG A
(Homo
sapiens) 		3 / 3 PHE A 196
TYR A 236
TYR A 234
 None
 0.95A 1x70B-5l7kA:
undetectable		 1x70B-5l7kA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5l7k PROTEIN UNC-119
HOMOLOG A
(Homo
sapiens) 		5 / 12 PHE A  91
SER A 218
HIS A 165
TYR A 234
TYR A 194
 None
 1.28A 2prgB-5l7kA:
undetectable		 2prgB-5l7kA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5l7k PROTEIN UNC-119
HOMOLOG A
(Homo
sapiens) 		5 / 12 ILE A 105
PHE A 133
PHE A 137
SER A 218
TYR A 131
 None
 1.47A 3apwA-5l7kA:
undetectable		 3apwA-5l7kA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5l7k PROTEIN UNC-119
HOMOLOG A
(Homo
sapiens) 		5 / 12 PHE A  91
SER A 218
HIS A 165
TYR A 234
TYR A 194
 None
 1.29A 3dzyD-5l7kA:
undetectable		 3dzyD-5l7kA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5l7k PROTEIN UNC-119
HOMOLOG A
(Homo
sapiens) 		4 / 8 ALA A 232
SER A 216
SER A 218
TYR A 131
 None
 1.11A 3rodA-5l7kA:
undetectable		 3rodA-5l7kA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 5l7k PROTEIN UNC-119
HOMOLOG A
(Homo
sapiens) 		4 / 4 HIS A 192
GLU A 163
HIS A 165
LEU A 140
 None
 1.44A 4m2rA-5l7kA:
undetectable		 4m2rA-5l7kA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 5l7k PROTEIN UNC-119
HOMOLOG A
(Homo
sapiens) 		3 / 3 HIS A 165
LYS A 173
PHE A 175
 None
 1.34A 5klaA-5l7kA:
undetectable		 5klaA-5l7kA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5l7k PROTEIN UNC-119
HOMOLOG A
(Homo
sapiens) 		4 / 6 PHE A  91
SER A 218
HIS A 165
TYR A 194
 None
 1.17A 5ycnA-5l7kA:
undetectable		 5ycnA-5l7kA:
22.06