SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l7l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 5l7l ELP3 FAMILY, ELP3
FAMILY
(Dehalococcoides
mccartyi) 		3 / 3 THR A  41
PRO A  37
TYR A 231
 None
 0.86A 2dxrA-5l7lA:
undetectable		 2dxrA-5l7lA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2001_1
(SERUM ALBUMIN)		 5l7l ELP3 FAMILY, ELP3
FAMILY
(Dehalococcoides
mccartyi) 		5 / 12 LEU A 361
TYR A 429
ILE A 419
TYR A 428
GLY A 422
 None
 1.48A 2vufA-5l7lA:
undetectable		 2vufA-5l7lA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5l7l ELP3 FAMILY, ELP3
FAMILY
(Dehalococcoides
mccartyi) 		4 / 7 LEU A 401
GLU A 405
ILE A 419
ARG A 364
 None
 0.85A 2xkwA-5l7lA:
undetectable		 2xkwA-5l7lA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5l7l ELP3 FAMILY, ELP3
FAMILY
(Dehalococcoides
mccartyi) 		4 / 5 ARG A 147
PHE A  98
PHE A  87
LEU A  88
 None
 1.39A 3abmC-5l7lA:
undetectable
3abmJ-5l7lA:
undetectable		 3abmC-5l7lA:
20.62
3abmJ-5l7lA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GF2_A_SALA147_1
(146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR)		 5l7l ELP3 FAMILY, ELP3
FAMILY
(Dehalococcoides
mccartyi) 		4 / 4 TYR A 440
LEU A 383
ARG A 364
TYR A 190
 None
 1.46A 3gf2A-5l7lA:
0.0		 3gf2A-5l7lA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 5l7l ELP3 FAMILY, ELP3
FAMILY
(Dehalococcoides
mccartyi) 		3 / 3 HIS A 195
ARG A 155
GLU A 386
 None
 0.90A 3qf1A-5l7lA:
undetectable		 3qf1A-5l7lA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 5l7l ELP3 FAMILY, ELP3
FAMILY
(Dehalococcoides
mccartyi) 		5 / 12 GLY A 382
LEU A 370
TYR A 190
ALA A 408
LEU A 363
 None
 1.14A 3vywD-5l7lA:
undetectable		 3vywD-5l7lA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5l7l ELP3 FAMILY, ELP3
FAMILY
(Dehalococcoides
mccartyi) 		5 / 12 LEU A 401
ILE A 419
ALA A 418
GLY A 413
ALA A 404
 None
 0.82A 4enhA-5l7lA:
undetectable		 4enhA-5l7lA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 5l7l ELP3 FAMILY, ELP3
FAMILY
(Dehalococcoides
mccartyi) 		3 / 3 VAL A 156
PHE A  87
ARG A 147
 None
 0.87A 4xr4B-5l7lA:
undetectable		 4xr4B-5l7lA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 5l7l ELP3 FAMILY, ELP3
FAMILY
(Dehalococcoides
mccartyi) 		4 / 4 LEU A 228
ILE A 275
PRO A 270
LEU A 268
 None
ZN  A 501 (-3.8A)
None
None
 0.87A 5eb3A-5l7lA:
undetectable		 5eb3A-5l7lA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 5l7l ELP3 FAMILY, ELP3
FAMILY
(Dehalococcoides
mccartyi) 		3 / 3 GLY A  25
CYH A  30
CYH A  27
 None
FES  A 502 (-2.3A)
FES  A 502 (-2.3A)
 0.85A 5inzB-5l7lA:
undetectable		 5inzB-5l7lA:
5.13