SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 5l7n PLEXIN-A1
(Mus
musculus) 		5 / 10 ALA A 925
ASP A 924
VAL A 900
ILE A 922
GLY A 872
 None
 1.21A 1d4sA-5l7nA:
undetectable		 1d4sA-5l7nA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 5l7n PLEXIN-A1
(Mus
musculus) 		3 / 3 TRP A1003
ARG A1004
PHE A1001
 None
 1.45A 1zeaH-5l7nA:
4.1
1zeaL-5l7nA:
4.7		 1zeaH-5l7nA:
21.97
1zeaL-5l7nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 5l7n PLEXIN-A1
(Mus
musculus) 		5 / 9 ASN A1029
ILE A1028
ASP A 989
GLY A 872
ALA A 986
 None
 1.38A 2dtjA-5l7nA:
undetectable
2dtjB-5l7nA:
undetectable		 2dtjA-5l7nA:
18.27
2dtjB-5l7nA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 5l7n PLEXIN-A1
(Mus
musculus) 		4 / 6 PRO A 907
LEU A 904
ARG A 879
GLY A 877
 None
 1.09A 2hs2B-5l7nA:
undetectable		 2hs2B-5l7nA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5l7n PLEXIN-A1
(Mus
musculus) 		4 / 8 ILE A1079
PHE A1142
GLY A1061
GLY A1060
 None
 0.90A 2qx4A-5l7nA:
undetectable
2qx4B-5l7nA:
undetectable		 2qx4A-5l7nA:
19.76
2qx4B-5l7nA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5l7n PLEXIN-A1
(Mus
musculus) 		5 / 10 GLY A1223
GLY A1061
THR A1062
ASN A1090
ILE A1057
 None
 1.32A 3fw1A-5l7nA:
undetectable		 3fw1A-5l7nA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 5l7n PLEXIN-A1
(Mus
musculus) 		3 / 3 HIS A 899
PHE A 954
PHE A 956
 None
 0.72A 3lk0D-5l7nA:
undetectable		 3lk0D-5l7nA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5l7n PLEXIN-A1
(Mus
musculus) 		5 / 11 PHE A 954
VAL A 957
ILE A 922
ALA A 986
ALA A1031
 None
 1.07A 3mdtB-5l7nA:
undetectable		 3mdtB-5l7nA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5l7n PLEXIN-A1
(Mus
musculus) 		5 / 8 ALA A 986
GLY A 872
THR A 871
ARG A1004
THR A 878
 None
 1.43A 3rglA-5l7nA:
undetectable		 3rglA-5l7nA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 5l7n PLEXIN-A1
(Mus
musculus) 		4 / 5 ILE A1024
ASN A1041
TYR A1042
ILE A 994
 None
NAG  A1303 (-1.9A)
None
None
 0.94A 4jtpA-5l7nA:
undetectable		 4jtpA-5l7nA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_2
(SUGAR KINASE)		 5l7n PLEXIN-A1
(Mus
musculus) 		4 / 4 SER A1056
ILE A1051
TYR A1144
PRO A1053
 None
EDO  A1304 ( 4.6A)
None
None
 1.39A 4k8pA-5l7nA:
0.0		 4k8pA-5l7nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_2
(SUGAR KINASE)		 5l7n PLEXIN-A1
(Mus
musculus) 		4 / 4 SER A1056
ILE A1051
TYR A1144
PRO A1053
 None
EDO  A1304 ( 4.6A)
None
None
 1.40A 4k8pB-5l7nA:
0.0		 4k8pB-5l7nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_2
(SUGAR KINASE)		 5l7n PLEXIN-A1
(Mus
musculus) 		4 / 4 SER A1056
ILE A1051
TYR A1144
PRO A1053
 None
EDO  A1304 ( 4.6A)
None
None
 1.40A 4k8tA-5l7nA:
undetectable		 4k8tA-5l7nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_2
(SUGAR KINASE)		 5l7n PLEXIN-A1
(Mus
musculus) 		4 / 4 SER A1056
ILE A1051
TYR A1144
PRO A1053
 None
EDO  A1304 ( 4.6A)
None
None
 1.38A 4k8tB-5l7nA:
undetectable		 4k8tB-5l7nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_2
(SUGAR KINASE)		 5l7n PLEXIN-A1
(Mus
musculus) 		4 / 4 SER A1056
ILE A1051
TYR A1144
PRO A1053
 None
EDO  A1304 ( 4.6A)
None
None
 1.39A 4k93A-5l7nA:
undetectable		 4k93A-5l7nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_2
(SUGAR KINASE)		 5l7n PLEXIN-A1
(Mus
musculus) 		4 / 4 SER A1056
ILE A1051
TYR A1144
PRO A1053
 None
EDO  A1304 ( 4.6A)
None
None
 1.40A 4k93B-5l7nA:
undetectable		 4k93B-5l7nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_2
(SUGAR KINASE)		 5l7n PLEXIN-A1
(Mus
musculus) 		4 / 4 SER A1056
ILE A1051
TYR A1144
PRO A1053
 None
EDO  A1304 ( 4.6A)
None
None
 1.39A 4k9cA-5l7nA:
undetectable		 4k9cA-5l7nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_2
(SUGAR KINASE)		 5l7n PLEXIN-A1
(Mus
musculus) 		4 / 4 SER A1056
ILE A1051
TYR A1144
PRO A1053
 None
EDO  A1304 ( 4.6A)
None
None
 1.38A 4k9cB-5l7nA:
0.0		 4k9cB-5l7nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_2
(SUGAR KINASE)		 5l7n PLEXIN-A1
(Mus
musculus) 		4 / 4 SER A1056
ILE A1051
TYR A1144
PRO A1053
 None
EDO  A1304 ( 4.6A)
None
None
 1.39A 4k9iA-5l7nA:
0.0		 4k9iA-5l7nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_2
(SUGAR KINASE)		 5l7n PLEXIN-A1
(Mus
musculus) 		4 / 4 SER A1056
ILE A1051
TYR A1144
PRO A1053
 None
EDO  A1304 ( 4.6A)
None
None
 1.39A 4k9iB-5l7nA:
0.0		 4k9iB-5l7nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5l7n PLEXIN-A1
(Mus
musculus) 		4 / 4 SER A1056
ILE A1051
TYR A1144
PRO A1053
 None
EDO  A1304 ( 4.6A)
None
None
 1.39A 4lbxA-5l7nA:
undetectable		 4lbxA-5l7nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5l7n PLEXIN-A1
(Mus
musculus) 		4 / 4 SER A1056
ILE A1051
TYR A1144
PRO A1053
 None
EDO  A1304 ( 4.6A)
None
None
 1.39A 4lbxB-5l7nA:
undetectable		 4lbxB-5l7nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5l7n PLEXIN-A1
(Mus
musculus) 		4 / 4 SER A1056
ILE A1051
TYR A1144
PRO A1053
 None
EDO  A1304 ( 4.6A)
None
None
 1.40A 4lc4A-5l7nA:
undetectable		 4lc4A-5l7nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5l7n PLEXIN-A1
(Mus
musculus) 		4 / 4 SER A1056
ILE A1051
TYR A1144
PRO A1053
 None
EDO  A1304 ( 4.6A)
None
None
 1.41A 4lc4B-5l7nA:
undetectable		 4lc4B-5l7nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5l7n PLEXIN-A1
(Mus
musculus) 		5 / 12 ALA A 925
VAL A 903
LEU A 949
ALA A 933
LEU A 867
 None
 1.12A 4qrcA-5l7nA:
undetectable		 4qrcA-5l7nA:
21.61