SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		5 / 11 MET A 528
GLY A 456
VAL A 479
MET A 532
ILE A 481
 None
 1.24A 1pk9C-5l8sA:
2.1		 1pk9C-5l8sA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		5 / 11 MET A 528
GLY A 456
VAL A 479
MET A 532
ILE A 481
 None
 1.22A 1vhwA-5l8sA:
2.1
1vhwD-5l8sA:
undetectable		 1vhwA-5l8sA:
19.21
1vhwD-5l8sA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		5 / 11 MET A 528
GLY A 456
VAL A 479
MET A 532
ILE A 481
 None
 1.25A 1vhwC-5l8sA:
undetectable
1vhwE-5l8sA:
2.0		 1vhwC-5l8sA:
19.21
1vhwE-5l8sA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		5 / 11 MET A 528
GLY A 456
VAL A 479
MET A 532
ILE A 481
 None
 1.26A 1vhwA-5l8sA:
2.1
1vhwD-5l8sA:
undetectable		 1vhwA-5l8sA:
19.21
1vhwD-5l8sA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		5 / 11 MET A 528
GLY A 456
VAL A 479
MET A 532
ILE A 481
 None
 1.22A 1vhwC-5l8sA:
undetectable
1vhwE-5l8sA:
2.0		 1vhwC-5l8sA:
19.21
1vhwE-5l8sA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		3 / 3 MET A 341
ASN A 331
GLN A 327
 None
 0.93A 1xoqB-5l8sA:
undetectable		 1xoqB-5l8sA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 6 LEU A 272
TYR A 261
ILE A 305
GLY A 301
 None
 0.95A 2du8A-5l8sA:
undetectable		 2du8A-5l8sA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 6 LEU A 272
TYR A 261
ILE A 305
GLY A 301
 None
 0.94A 2du8B-5l8sA:
undetectable		 2du8B-5l8sA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 4 PRO A 430
TYR A 459
GLY A 410
THR A 419
 None
 1.04A 3ib0A-5l8sA:
undetectable		 3ib0A-5l8sA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 8 TYR A 179
GLU A 198
SER A 155
ILE A 501
 None
 0.94A 3jz0B-5l8sA:
undetectable		 3jz0B-5l8sA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 6 GLY A 379
GLY A 380
SER A 458
HIS A 572
 None
 0.82A 3o9mB-5l8sA:
16.7		 3o9mB-5l8sA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		5 / 12 VAL A 478
ILE A 535
PHE A 396
ILE A 374
TYR A 401
 None
 1.31A 3q5pA-5l8sA:
undetectable		 3q5pA-5l8sA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 5 GLY A 571
ASP A 540
ARG A 542
MET A 388
 None
 1.30A 3qx3A-5l8sA:
undetectable		 3qx3A-5l8sA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 5 GLY A 571
ASP A 540
ARG A 542
MET A 388
 None
 1.28A 3qx3B-5l8sA:
undetectable		 3qx3B-5l8sA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9X_B_ACTB502_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 4 LYS A 128
GLU A 108
GLN A  87
TYR A 110
 None
 1.36A 3r9xB-5l8sA:
4.2		 3r9xB-5l8sA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		5 / 12 TYR A 275
LEU A 227
VAL A 240
THR A 213
THR A 209
 None
 1.28A 4fiaA-5l8sA:
undetectable		 4fiaA-5l8sA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		5 / 12 TYR A 275
LEU A 227
VAL A 240
THR A 213
THR A 209
 None
 1.28A 4fiaA-5l8sA:
undetectable		 4fiaA-5l8sA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 8 SER A 247
GLN A 249
VAL A 202
THR A 178
 None
 1.15A 4lnwA-5l8sA:
undetectable		 4lnwA-5l8sA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 6 SER A 247
GLN A 249
VAL A 202
THR A 178
 None
 1.26A 4lnxA-5l8sA:
undetectable		 4lnxA-5l8sA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 4 TYR A 171
THR A 157
GLY A 152
LEU A 148
 None
 1.48A 4w5nA-5l8sA:
4.2		 4w5nA-5l8sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 6 ASP A 369
LYS A 451
THR A 402
THR A 373
 SO4  A 701 (-3.7A)
None
SO4  A 701 ( 4.9A)
None
 1.20A 4w5qA-5l8sA:
4.4		 4w5qA-5l8sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 6 ASP A 369
LYS A 451
THR A 402
THR A 373
 SO4  A 701 (-3.7A)
None
SO4  A 701 ( 4.9A)
None
 1.24A 4w5rA-5l8sA:
4.3		 4w5rA-5l8sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 6 ASP A 369
LYS A 451
THR A 402
THR A 373
 SO4  A 701 (-3.7A)
None
SO4  A 701 ( 4.9A)
None
 1.26A 4w5tA-5l8sA:
2.3		 4w5tA-5l8sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 7 PHE A 183
GLU A 153
THR A 136
PHE A 133
 None
 1.06A 4wnvD-5l8sA:
undetectable		 4wnvD-5l8sA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		3 / 3 SER A  25
ALA A 298
VAL A 297
 None
 0.56A 4x1iA-5l8sA:
4.0		 4x1iA-5l8sA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 5 VAL A 422
ASP A 425
PHE A 408
GLY A 429
 None
 1.19A 4xp6A-5l8sA:
undetectable		 4xp6A-5l8sA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 6 ASP A 369
LYS A 451
THR A 402
THR A 373
 SO4  A 701 (-3.7A)
None
SO4  A 701 ( 4.9A)
None
 1.26A 4z4cA-5l8sA:
2.2		 4z4cA-5l8sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 6 ASP A 369
LYS A 451
THR A 402
THR A 373
 SO4  A 701 (-3.7A)
None
SO4  A 701 ( 4.9A)
None
 1.25A 4z4fA-5l8sA:
2.1		 4z4fA-5l8sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 6 ASP A 369
LYS A 451
THR A 402
THR A 373
 SO4  A 701 (-3.7A)
None
SO4  A 701 ( 4.9A)
None
 1.26A 4z4iA-5l8sA:
4.4		 4z4iA-5l8sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 6 GLY A 413
THR A 412
SER A 247
VAL A 265
 None
 1.12A 5ewuB-5l8sA:
undetectable		 5ewuB-5l8sA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		3 / 3 SER A  25
ALA A 298
VAL A 297
 None
 0.53A 5eypA-5l8sA:
3.4		 5eypA-5l8sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		5 / 12 ILE A 292
GLY A 307
HIS A 314
VAL A 312
ILE A 271
 None
 1.01A 5n0sA-5l8sA:
undetectable		 5n0sA-5l8sA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		5 / 12 ILE A 292
GLY A 307
HIS A 314
VAL A 312
ILE A 271
 None
 1.02A 5n0tA-5l8sA:
undetectable		 5n0tA-5l8sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		5 / 12 ILE A 292
GLY A 307
HIS A 314
VAL A 312
ILE A 271
 None
 0.99A 5n0tB-5l8sA:
2.4		 5n0tB-5l8sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		5 / 12 ILE A 292
GLY A 307
HIS A 314
VAL A 312
ILE A 271
 None
 0.98A 5n0wB-5l8sA:
2.1		 5n0wB-5l8sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		5 / 12 ILE A 292
GLY A 307
HIS A 314
VAL A 312
ILE A 271
 None
 0.98A 5n0xA-5l8sA:
undetectable		 5n0xA-5l8sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		5 / 12 ILE A 292
GLY A 307
HIS A 314
VAL A 312
ILE A 271
 None
 0.97A 5n4iA-5l8sA:
undetectable		 5n4iA-5l8sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		3 / 3 ARG A 409
ARG A 431
ARG A 515
 None
 0.94A 5vcgA-5l8sA:
undetectable		 5vcgA-5l8sA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 5 GLY A 571
ASP A 540
ARG A 542
MET A 388
 None
 1.37A 5zrfB-5l8sA:
2.7		 5zrfB-5l8sA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 4 GLY A 571
ASP A 540
ARG A 542
MET A 388
 None
 1.39A 5zrfA-5l8sA:
1.2		 5zrfA-5l8sA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 5 GLN A  11
VAL A 333
PRO A   7
THR A 311
 None
 1.12A 6cduA-5l8sA:
undetectable
6cduB-5l8sA:
undetectable		 6cduA-5l8sA:
18.30
6cduB-5l8sA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5l8s AMINO ACYL PEPTIDASE
(Sporosarcina
psychrophila) 		4 / 5 GLN A  11
VAL A 333
PRO A   7
THR A 311
 None
 1.21A 6cduI-5l8sA:
undetectable
6cduJ-5l8sA:
undetectable		 6cduI-5l8sA:
18.30
6cduJ-5l8sA:
18.30