SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l8v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		5 / 9 GLY A 163
GLY A 111
GLY A 127
GLY A 126
ASP A 121
 None
 0.71A 1mxdA-5l8vA:
undetectable		 1mxdA-5l8vA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		5 / 11 GLY A 163
GLY A 111
GLY A 127
GLY A 126
ASP A 121
 None
 0.69A 1mxgA-5l8vA:
1.9		 1mxgA-5l8vA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		5 / 11 THR A 310
VAL A 237
VAL A 279
GLU A 135
LEU A 261
 None
 0.89A 1t6zB-5l8vA:
undetectable		 1t6zB-5l8vA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB201_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		5 / 10 GLU A 195
GLN A 156
MET A 221
MET A 222
SER A 225
 None
 1.45A 1wrkA-5l8vA:
undetectable
1wrkB-5l8vA:
undetectable		 1wrkA-5l8vA:
16.52
1wrkB-5l8vA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF209_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		5 / 10 GLU A 195
GLN A 156
MET A 221
MET A 222
SER A 225
 None
 1.37A 1wrlE-5l8vA:
undetectable
1wrlF-5l8vA:
undetectable		 1wrlE-5l8vA:
16.52
1wrlF-5l8vA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		4 / 5 THR A 176
SER A 239
ASP A 238
SER A 242
 None
 1.21A 2hdnA-5l8vA:
undetectable
2hdnB-5l8vA:
undetectable
2hdnD-5l8vA:
undetectable		 2hdnA-5l8vA:
11.44
2hdnB-5l8vA:
23.38
2hdnD-5l8vA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		4 / 5 SER A 242
THR A 176
SER A 239
ASP A 238
 None
 1.18A 2hdnB-5l8vA:
undetectable
2hdnC-5l8vA:
undetectable
2hdnD-5l8vA:
undetectable		 2hdnB-5l8vA:
23.38
2hdnC-5l8vA:
11.44
2hdnD-5l8vA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		4 / 6 THR A 176
SER A 239
ASP A 238
SER A 242
 None
 1.22A 2hdnI-5l8vA:
undetectable
2hdnJ-5l8vA:
undetectable
2hdnL-5l8vA:
undetectable		 2hdnI-5l8vA:
11.44
2hdnJ-5l8vA:
23.38
2hdnL-5l8vA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		4 / 6 SER A 242
THR A 176
SER A 239
ASP A 238
 None
 1.20A 2hdnJ-5l8vA:
undetectable
2hdnK-5l8vA:
undetectable
2hdnL-5l8vA:
undetectable		 2hdnJ-5l8vA:
23.38
2hdnK-5l8vA:
11.44
2hdnL-5l8vA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		4 / 6 LEU A 311
SER A 117
PHE A 340
ASP A 349
 None
 1.09A 2vn1B-5l8vA:
undetectable		 2vn1B-5l8vA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		5 / 11 VAL A 136
LEU A 120
SER A 142
ILE A 347
ALA A 152
 None
None
PO4  A 401 (-4.8A)
None
None
 1.17A 2zbzA-5l8vA:
undetectable		 2zbzA-5l8vA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		4 / 8 THR A 241
LEU A 261
GLN A 258
HIS A 303
 None
 1.08A 3kp2A-5l8vA:
undetectable
3kp2B-5l8vA:
undetectable		 3kp2A-5l8vA:
20.89
3kp2B-5l8vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		5 / 10 GLU A 135
THR A 241
LEU A 261
GLN A 258
HIS A 303
 None
 1.16A 3kp3A-5l8vA:
0.0
3kp3B-5l8vA:
0.0		 3kp3A-5l8vA:
20.89
3kp3B-5l8vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		5 / 12 VAL A 313
LEU A 124
ALA A 309
VAL A 281
LEU A 147
 None
 1.08A 3ln1A-5l8vA:
undetectable		 3ln1A-5l8vA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		5 / 12 VAL A 313
LEU A 124
ALA A 309
VAL A 281
LEU A 147
 None
 1.08A 3ln1D-5l8vA:
undetectable		 3ln1D-5l8vA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		4 / 7 ILE A 277
ARG A 226
GLY A 166
VAL A 155
 None
 0.98A 4a3uB-5l8vA:
undetectable		 4a3uB-5l8vA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		4 / 6 LEU A 261
LEU A 305
ILE A 304
THR A 310
 None
 0.73A 4do3B-5l8vA:
undetectable		 4do3B-5l8vA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		4 / 7 LEU A 234
THR A 282
THR A 134
VAL A 136
 None
 0.84A 4ik7A-5l8vA:
undetectable		 4ik7A-5l8vA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		5 / 12 LEU A 268
LEU A 147
ILE A 236
VAL A 313
LEU A 124
 None
 0.93A 4y0pA-5l8vA:
undetectable		 4y0pA-5l8vA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		3 / 3 GLU A 180
THR A 145
HIS A 149
 None
PO4  A 401 (-4.3A)
None
 0.79A 4ydqB-5l8vA:
undetectable		 4ydqB-5l8vA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Pyrococcus
furiosus) 		3 / 3 ARG A 257
HIS A 303
ARG A 245
 None
 1.17A 5iaoC-5l8vA:
undetectable		 5iaoC-5l8vA:
25.11