SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J2P_D_SC2D1290_1 (FICOLIN-2)	5l8x	TETRAHYDROMETHANOPTE RIN S-METHYLTRANSFERASE SUBUNIT A (Methanocaldococc us jannaschii)	4 / 5	GLY A 98 TRP A 95 ARG A 127 LEU A 94	None	1.23A	2j2pD-5l8xA: undetectable 2j2pF-5l8xA: undetectable	2j2pD-5l8xA: 18.84 2j2pF-5l8xA: 18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IJD_B_C2FB314_0 (UNCHARACTERIZED PROTEIN)	5l8x	TETRAHYDROMETHANOPTE RIN S-METHYLTRANSFERASE SUBUNIT A (Methanocaldococc us jannaschii)	5 / 12	CYH A 52 VAL A 30 GLY A 50 ILE A 72 ILE A 67	LMR A 201 (-4.6A) None None None None	1.02A	3ijdB-5l8xA: undetectable	3ijdB-5l8xA: 18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C5N_C_PXLC300_1 (PHOSPHOMETHYLPYRIMID INE KINASE)	5l8x	TETRAHYDROMETHANOPTE RIN S-METHYLTRANSFERASE SUBUNIT A (Methanocaldococc us jannaschii)	4 / 8	GLY A 103 ASP A 101 GLY A 100 VAL A 123	None	0.76A	4c5nC-5l8xA: 3.1	4c5nC-5l8xA: 19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I41_A_MIXA501_1 (SERINE/THREONINE-PRO TEIN KINASE PIM-1)	5l8x	TETRAHYDROMETHANOPTE RIN S-METHYLTRANSFERASE SUBUNIT A (Methanocaldococc us jannaschii)	5 / 12	ILE A 149 THR A 146 VAL A 19 ASP A 43 ILE A 42	None	1.40A	4i41A-5l8xA: undetectable	4i41A-5l8xA: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J83_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	5l8x	TETRAHYDROMETHANOPTE RIN S-METHYLTRANSFERASE SUBUNIT A (Methanocaldococc us jannaschii)	5 / 11	ILE A 167 ALA A 122 GLY A 98 ASN A 119 GLU A 60	None	1.46A	4j83A-5l8xA: undetectable	4j83A-5l8xA: 19.69

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2J2P_D_SC2D1290_1","FICOLIN-2;FICOLIN-2","5l8x","TETRAHYDROMETHANOPTERIN S-METHYLTRANSFERASE SUBUNIT A","Methanocaldococcus jannaschii",4,"GLY A  98;TRP A  95;ARG A 127;LEU A  94","None","1.23A","2j2pD-5l8xA:undetectable;2j2pF-5l8xA:undetectable","2j2pD-5l8xA:18.84;2j2pF-5l8xA:18.84"],["3IJD_B_C2FB314_0","UNCHARACTERIZED PROTEIN","5l8x","TETRAHYDROMETHANOPTERIN S-METHYLTRANSFERASE SUBUNIT A","Methanocaldococcus jannaschii",5,"CYH A  52;VAL A  30;GLY A  50;ILE A  72;ILE A  67","LMR A 201 (-4.6A);None;None;None;None","1.02A","3ijdB-5l8xA:undetectable","3ijdB-5l8xA:18.47"],["4C5N_C_PXLC300_1","PHOSPHOMETHYLPYRIMIDINE KINASE","5l8x","TETRAHYDROMETHANOPTERIN S-METHYLTRANSFERASE SUBUNIT A","Methanocaldococcus jannaschii",4,"GLY A 103;ASP A 101;GLY A 100;VAL A 123","None","0.76A","4c5nC-5l8xA:3.1","4c5nC-5l8xA:19.20"],["4I41_A_MIXA501_1","SERINE\/THREONINE-PROTEIN KINASE PIM-1","5l8x","TETRAHYDROMETHANOPTERIN S-METHYLTRANSFERASE SUBUNIT A","Methanocaldococcus jannaschii",5,"ILE A 149;THR A 146;VAL A  19;ASP A  43;ILE A  42","None","1.40A","4i41A-5l8xA:undetectable","4i41A-5l8xA:22.22"],["4J83_A_SAMA401_0","HISTONE-LYSINE N-METHYLTRANSFERASE SETD7","5l8x","TETRAHYDROMETHANOPTERIN S-METHYLTRANSFERASE SUBUNIT A","Methanocaldococcus jannaschii",5,"ILE A 167;ALA A 122;GLY A  98;ASN A 119;GLU A  60","None","1.46A","4j83A-5l8xA:undetectable","4j83A-5l8xA:19.69"]]