SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l94'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		4 / 6 PRO A  37
PHE A  50
GLU A  30
GLN A  39
 None
 1.47A 1l2iB-5l94A:
undetectable		 1l2iB-5l94A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		4 / 7 LEU A 227
GLN A 226
LEU A 217
PHE A 235
 None
 1.02A 2einC-5l94A:
undetectable
2einJ-5l94A:
undetectable		 2einC-5l94A:
19.00
2einJ-5l94A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		4 / 6 LEU A 227
GLN A 226
LEU A 217
PHE A 235
 None
 0.97A 2einP-5l94A:
undetectable
2einW-5l94A:
undetectable		 2einP-5l94A:
19.00
2einW-5l94A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 12 PRO A 386
PHE A  23
GLU A 260
PHE A 382
TRP A 378
 None
 1.49A 2oa1A-5l94A:
undetectable		 2oa1A-5l94A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2003_0
(TRYPTOPHAN
HALOGENASE)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 12 PRO A 386
PHE A  23
GLU A 260
PHE A 382
TRP A 378
 None
 1.48A 2oa1B-5l94A:
undetectable		 2oa1B-5l94A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		4 / 8 ALA A  79
TYR A 199
GLY A 234
ILE A 237
 None
 0.79A 2zm9A-5l94A:
undetectable		 2zm9A-5l94A:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		6 / 12 ILE A  85
LYS A 187
LEU A 238
ILE A 241
ALA A 242
THR A 246
 HEM  A 501 (-4.4A)
None
HEM  A 501 (-4.4A)
TES  A 502 (-4.0A)
HEM  A 501 (-3.5A)
HEM  A 501 (-3.4A)
 0.47A 3a50A-5l94A:
49.2		 3a50A-5l94A:
34.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 11 ILE A  85
LYS A 187
LEU A 238
ILE A 241
THR A 246
 HEM  A 501 (-4.4A)
None
HEM  A 501 (-4.4A)
TES  A 502 (-4.0A)
HEM  A 501 (-3.4A)
 0.45A 3a50B-5l94A:
49.7		 3a50B-5l94A:
34.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 11 ILE A  85
LYS A 187
LEU A 238
ILE A 241
THR A 246
 HEM  A 501 (-4.4A)
None
HEM  A 501 (-4.4A)
TES  A 502 (-4.0A)
HEM  A 501 (-3.4A)
 0.36A 3a50C-5l94A:
49.8		 3a50C-5l94A:
34.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 12 ILE A  85
LYS A 187
ILE A 241
ALA A 242
THR A 246
 HEM  A 501 (-4.4A)
None
TES  A 502 (-4.0A)
HEM  A 501 (-3.5A)
HEM  A 501 (-3.4A)
 0.44A 3a50D-5l94A:
49.6		 3a50D-5l94A:
34.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 12 ILE A  85
LYS A 187
LEU A 238
ILE A 241
THR A 246
 HEM  A 501 (-4.4A)
None
HEM  A 501 (-4.4A)
TES  A 502 (-4.0A)
HEM  A 501 (-3.4A)
 0.37A 3a50E-5l94A:
49.7		 3a50E-5l94A:
34.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		6 / 11 ILE A  85
LYS A 187
LEU A 238
ILE A 241
THR A 246
VAL A 289
 HEM  A 501 (-4.4A)
None
HEM  A 501 (-4.4A)
TES  A 502 (-4.0A)
HEM  A 501 (-3.4A)
TES  A 502 (-4.8A)
 0.43A 3a51A-5l94A:
49.3		 3a51A-5l94A:
34.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 12 ILE A  85
LYS A 187
ILE A 241
THR A 246
VAL A 289
 HEM  A 501 (-4.4A)
None
TES  A 502 (-4.0A)
HEM  A 501 (-3.4A)
TES  A 502 (-4.8A)
 0.36A 3a51C-5l94A:
49.9		 3a51C-5l94A:
34.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		6 / 12 ILE A  85
LYS A 187
LEU A 238
ILE A 241
THR A 246
VAL A 289
 HEM  A 501 (-4.4A)
None
HEM  A 501 (-4.4A)
TES  A 502 (-4.0A)
HEM  A 501 (-3.4A)
TES  A 502 (-4.8A)
 0.45A 3a51D-5l94A:
49.7		 3a51D-5l94A:
34.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		6 / 12 ILE A  85
LYS A 187
ILE A 241
ALA A 242
THR A 246
VAL A 289
 HEM  A 501 (-4.4A)
None
TES  A 502 (-4.0A)
HEM  A 501 (-3.5A)
HEM  A 501 (-3.4A)
TES  A 502 (-4.8A)
 0.46A 3a51E-5l94A:
49.7		 3a51E-5l94A:
34.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 12 ILE A 232
GLY A 234
ALA A 242
ILE A 147
VAL A  99
 None
None
HEM  A 501 (-3.5A)
None
None
 1.21A 3adsB-5l94A:
undetectable		 3adsB-5l94A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		4 / 6 LEU A 227
GLN A 226
LEU A 217
PHE A 235
 None
 0.98A 3ag1C-5l94A:
undetectable
3ag1J-5l94A:
undetectable		 3ag1C-5l94A:
19.00
3ag1J-5l94A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 12 THR A  78
VAL A 169
ALA A 190
THR A 246
VAL A 289
 None
TES  A 502 ( 4.4A)
None
HEM  A 501 (-3.4A)
TES  A 502 (-4.8A)
 1.12A 3czhA-5l94A:
33.6		 3czhA-5l94A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		3 / 3 ALA A 242
THR A 246
CYH A 352
 HEM  A 501 (-3.5A)
HEM  A 501 (-3.4A)
HEM  A 501 (-2.3A)
 0.67A 3e4eA-5l94A:
32.9		 3e4eA-5l94A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		3 / 3 ALA A 242
THR A 246
CYH A 352
 HEM  A 501 (-3.5A)
HEM  A 501 (-3.4A)
HEM  A 501 (-2.3A)
 0.63A 3e4eB-5l94A:
28.2		 3e4eB-5l94A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 12 LEU A 283
THR A 247
GLU A 280
LEU A 366
PHE A 345
 None
HEM  A 501 ( 4.3A)
None
None
HEM  A 501 (-4.5A)
 1.37A 3g1uC-5l94A:
undetectable		 3g1uC-5l94A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 10 ASN A 191
LEU A 238
GLU A 230
SER A  83
ASN A  86
 None
HEM  A 501 (-4.4A)
None
None
None
 1.42A 3kp3A-5l94A:
1.2
3kp3B-5l94A:
1.3		 3kp3A-5l94A:
17.09
3kp3B-5l94A:
17.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 10 LEU A 238
ILE A 241
ALA A 242
THR A 246
VAL A 289
 HEM  A 501 (-4.4A)
TES  A 502 (-4.0A)
HEM  A 501 (-3.5A)
HEM  A 501 (-3.4A)
TES  A 502 (-4.8A)
 0.37A 3r9cA-5l94A:
47.4		 3r9cA-5l94A:
35.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 12 ILE A  85
LYS A 187
LEU A 238
ILE A 241
ALA A 242
 HEM  A 501 (-4.4A)
None
HEM  A 501 (-4.4A)
TES  A 502 (-4.0A)
HEM  A 501 (-3.5A)
 0.66A 3vrmA-5l94A:
49.5		 3vrmA-5l94A:
34.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		4 / 5 TRP A 111
GLY A 152
ALA A 148
PHE A 103
 None
 1.48A 3wqwA-5l94A:
undetectable		 3wqwA-5l94A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		4 / 6 ILE A 251
THR A 254
VAL A 144
ASP A 166
 None
 1.16A 4iaqA-5l94A:
undetectable		 4iaqA-5l94A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		4 / 7 ILE A 251
THR A 254
VAL A 144
ASP A 166
 None
 1.17A 4iarA-5l94A:
undetectable		 4iarA-5l94A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 11 LEU A 240
SER A 165
LEU A  80
LEU A 151
LEU A 194
 None
 1.23A 4or0A-5l94A:
undetectable		 4or0A-5l94A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 11 LEU A 240
SER A 165
LEU A  80
LEU A 151
LEU A 194
 None
 1.18A 4or0B-5l94A:
undetectable		 4or0B-5l94A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		4 / 6 TYR A 256
ASN A 253
GLU A 260
PHE A  26
 None
 1.08A 4twdG-5l94A:
undetectable
4twdH-5l94A:
undetectable		 4twdG-5l94A:
22.20
4twdH-5l94A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 12 PHE A  23
LEU A 384
GLY A 394
SER A 252
LEU A 398
 None
 1.43A 4zbrA-5l94A:
undetectable		 4zbrA-5l94A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		4 / 6 ARG A 294
HIS A  92
ARG A  96
ILE A 349
 HEM  A 501 (-3.0A)
HEM  A 501 (-3.8A)
HEM  A 501 (-3.9A)
None
 1.42A 5a06A-5l94A:
undetectable		 5a06A-5l94A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		4 / 8 ARG A 200
GLU A 204
PRO A 154
GLY A 152
 None
 1.14A 5kgpA-5l94A:
undetectable		 5kgpA-5l94A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 10 ILE A 370
THR A 254
ILE A 255
ILE A 251
ILE A 134
 None
 1.11A 5murE-5l94A:
undetectable		 5murE-5l94A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		4 / 7 GLN A 375
ASP A 371
ALA A 367
LEU A 275
 None
 1.02A 5nwvA-5l94A:
undetectable		 5nwvA-5l94A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		4 / 4 LEU A 369
LEU A 366
SER A 139
ALA A 362
 None
 1.02A 5uunA-5l94A:
undetectable		 5uunA-5l94A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 12 LEU A 283
THR A 247
GLU A 280
LEU A 366
PHE A 345
 None
HEM  A 501 ( 4.3A)
None
None
HEM  A 501 (-4.5A)
 1.48A 6gbnB-5l94A:
undetectable		 6gbnB-5l94A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_1
(-)		 5l94 CYTOCHROME P450
(Bacillus
megaterium) 		5 / 12 LEU A 283
THR A 247
GLU A 280
LEU A 366
PHE A 345
 None
HEM  A 501 ( 4.3A)
None
None
HEM  A 501 (-4.5A)
 1.48A 6gbnC-5l94A:
undetectable		 6gbnC-5l94A:
19.00