SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l9p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5l9p PERIPLASMIC BINDING
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 12 ILE A 172
ALA A 175
ALA A 176
LEU A 203
HIS A 339
 None
 1.03A 1fbyA-5l9pA:
undetectable		 1fbyA-5l9pA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5l9p PERIPLASMIC BINDING
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 12 ILE A 172
ALA A 175
ALA A 176
LEU A 203
HIS A 339
 None
 1.04A 1fbyB-5l9pA:
undetectable		 1fbyB-5l9pA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5l9p PERIPLASMIC BINDING
PROTEIN
(Agrobacterium
tumefaciens) 		3 / 3 ASN A  68
ASP A  92
ARG A 351
 None
 0.90A 3k13C-5l9pA:
undetectable		 3k13C-5l9pA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5l9p PERIPLASMIC BINDING
PROTEIN
(Agrobacterium
tumefaciens) 		5 / 12 GLY A 217
ALA A 220
ALA A 163
VAL A 210
GLN A 219
 SO4  A 402 (-3.3A)
None
None
None
None
 1.49A 4ryaA-5l9pA:
7.4		 4ryaA-5l9pA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5l9p PERIPLASMIC BINDING
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 8 THR A 311
TYR A 310
THR A 317
GLN A 240
 None
 1.42A 5tzoB-5l9pA:
undetectable		 5tzoB-5l9pA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5l9p PERIPLASMIC BINDING
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 4 VAL A 120
LEU A 105
ASN A 301
ASP A 114
 None
None
SO4  A 403 (-3.6A)
None
 1.33A 5vcyA-5l9pA:
undetectable		 5vcyA-5l9pA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 5l9p PERIPLASMIC BINDING
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 7 GLN A 240
GLY A 236
ILE A 224
GLN A 219
 None
 0.99A 5vlmC-5l9pA:
undetectable		 5vlmC-5l9pA:
21.53