SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5l9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		3 / 3 ALA A  84
VAL A  82
TRP A  93
 None
 0.83A 1av2C-5l9sA:
undetectable
1av2D-5l9sA:
undetectable		 1av2C-5l9sA:
4.09
1av2D-5l9sA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		3 / 3 VAL A  82
VAL A  91
TRP A  93
 None
 0.95A 1av2C-5l9sA:
undetectable
1av2D-5l9sA:
undetectable		 1av2C-5l9sA:
4.09
1av2D-5l9sA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		3 / 3 ALA A  84
VAL A  82
TRP A  93
 None
 0.85A 1nt6A-5l9sA:
undetectable		 1nt6A-5l9sA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		3 / 3 ALA A  84
VAL A  82
TRP A  93
 None
 0.85A 1nt6B-5l9sA:
undetectable		 1nt6B-5l9sA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		5 / 12 PRO A 182
SER A 175
VAL A 221
ALA A 189
ALA A 188
 None
 1.28A 1nw5A-5l9sA:
undetectable		 1nw5A-5l9sA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		3 / 3 ALA A  84
VAL A  82
TRP A  93
 None
 0.86A 1w5uC-5l9sA:
undetectable
1w5uD-5l9sA:
undetectable		 1w5uC-5l9sA:
4.09
1w5uD-5l9sA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		4 / 6 PRO A 196
LEU A 190
ARG A 197
GLY A 264
 None
 1.07A 2hs2B-5l9sA:
undetectable		 2hs2B-5l9sA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		3 / 3 TRP A  93
ALA A  84
VAL A  82
 None
 0.85A 2izqA-5l9sA:
undetectable
2izqB-5l9sA:
undetectable		 2izqA-5l9sA:
4.09
2izqB-5l9sA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_D_CSCD1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		5 / 12 THR A 134
LEU A 115
TYR A  48
GLN A 141
HIS A 108
 None
 1.45A 2vaxD-5l9sA:
undetectable		 2vaxD-5l9sA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_J_CSCJ1385_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		5 / 12 THR A 134
LEU A 115
TYR A  48
GLN A 141
HIS A 108
 None
 1.50A 2vaxJ-5l9sA:
0.0		 2vaxJ-5l9sA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_K_CSCK1385_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		5 / 12 THR A 134
LEU A 115
TYR A  48
GLN A 141
HIS A 108
 None
 1.46A 2vaxK-5l9sA:
0.9		 2vaxK-5l9sA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		3 / 3 ARG A 234
ILE A 243
THR A 143
 None
 0.74A 3ia4D-5l9sA:
undetectable		 3ia4D-5l9sA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		3 / 3 ALA A  84
VAL A  82
TRP A  93
 None
 0.84A 3l8lA-5l9sA:
undetectable
3l8lB-5l9sA:
undetectable		 3l8lA-5l9sA:
4.09
3l8lB-5l9sA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		5 / 10 LEU A 140
ASP A 270
ILE A  41
LEU A  95
LEU A  52
 None
 1.08A 4odoC-5l9sA:
undetectable		 4odoC-5l9sA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		5 / 12 GLN A 159
LEU A 146
GLY A 259
ALA A 248
ILE A 243
 ACT  A 401 ( 4.8A)
None
ACT  A 401 ( 3.9A)
None
None
 1.29A 4xe5A-5l9sA:
undetectable		 4xe5A-5l9sA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		4 / 8 PHE A 266
ALA A 192
LEU A 191
GLY A 264
 None
 1.01A 4xk8a-5l9sA:
undetectable		 4xk8a-5l9sA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		5 / 9 LEU A 245
LEU A 146
ALA A 250
VAL A 230
ALA A 148
 None
 1.21A 5g44A-5l9sA:
undetectable		 5g44A-5l9sA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		5 / 12 LEU A 190
ALA A 188
THR A 160
LEU A 186
LEU A 212
 None
 1.19A 5nfjB-5l9sA:
undetectable		 5nfjB-5l9sA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		5 / 12 LEU A 190
ALA A 188
THR A 160
LEU A 186
LEU A 212
 None
 1.20A 5nfjC-5l9sA:
undetectable		 5nfjC-5l9sA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		4 / 8 ASN A 178
PHE A 179
GLN A 242
GLY A 241
 None
 0.97A 5nzxA-5l9sA:
undetectable		 5nzxA-5l9sA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		4 / 7 ASN A 178
PHE A 179
GLN A 242
GLY A 241
 None
 0.99A 5nzyA-5l9sA:
undetectable		 5nzyA-5l9sA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		3 / 3 TRP A 183
MET A 348
ASN A 345
 None
 1.42A 5uc1B-5l9sA:
undetectable		 5uc1B-5l9sA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		3 / 3 TRP A 183
MET A 348
ASN A 345
 None
 1.42A 5uc1A-5l9sA:
undetectable		 5uc1A-5l9sA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		4 / 8 TRP A 223
ARG A 224
GLN A 228
TRP A 244
 None
 1.12A 5vlmF-5l9sA:
undetectable		 5vlmF-5l9sA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)
(Agrobacterium
fabrum) 		3 / 3 TYR A  96
ARG A  79
THR A  83
 None
 0.77A 5z84J-5l9sA:
undetectable		 5z84J-5l9sA:
8.71