SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5la0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 10 LEU A 165
LEU A 210
GLU A 167
LEU A 308
HIS A 163
 None
 1.32A 1gwrA-5la0A:
undetectable		 1gwrA-5la0A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A 134
GLU A 167
TRP A  69
HIS A  90
 ARA  A 605 ( 4.0A)
None
None
None
 0.90A 1maaD-5la0A:
undetectable		 1maaD-5la0A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 TYR A 433
VAL A 449
PHE A 506
VAL A 457
THR A 467
 None
 1.24A 1q23B-5la0A:
undetectable		 1q23B-5la0A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A 411
ASN A 507
TRP A 481
 ARA  A 606 (-2.8A)
ARA  A 606 (-3.0A)
None
 1.26A 1r15C-5la0A:
1.8		 1r15C-5la0A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A 411
ASN A 507
TRP A 481
 ARA  A 606 (-2.8A)
ARA  A 606 (-3.0A)
None
 1.29A 1r15E-5la0A:
2.0		 1r15E-5la0A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 PRO A 177
THR A 261
GLY A 219
GLY A 221
GLN A 259
 None
 1.05A 1wg8A-5la0A:
undetectable		 1wg8A-5la0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASN A 170
GLU A 171
HIS A 253
TYR A 255
GLU A 279
 ARA  A 605 (-4.3A)
None
None
None
ARA  A 605 ( 4.4A)
 0.30A 2v3dA-5la0A:
14.7		 2v3dA-5la0A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		6 / 12 ILE A 115
GLU A  94
PHE A 150
ALA A 251
LEU A 308
ILE A 131
 None
 1.50A 2xkwB-5la0A:
undetectable		 2xkwB-5la0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASN A  46
ALA A  48
VAL A 265
PHE A 252
LEU A 300
 None
 1.31A 3hkuA-5la0A:
undetectable		 3hkuA-5la0A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 11 LEU A 165
LEU A 210
GLU A 167
LEU A 308
HIS A 163
 None
 1.36A 3hm1B-5la0A:
undetectable		 3hm1B-5la0A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		3 / 3 SER A 426
ASP A 392
ASN A 386
 None
CA  A 604 ( 2.4A)
None
 1.03A 3lsfB-5la0A:
undetectable
3lsfE-5la0A:
undetectable		 3lsfB-5la0A:
20.82
3lsfE-5la0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 PHE A 276
CYH A 275
SER A 213
HIS A  90
VAL A 130
 None
 1.48A 3sp6A-5la0A:
undetectable		 3sp6A-5la0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 9 ILE A 511
GLN A 495
LEU A 497
VAL A 459
LEU A 445
 None
 1.17A 4g1bC-5la0A:
2.0		 4g1bC-5la0A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 490
LEU A 445
ASN A 444
ILE A 435
ILE A 511
 None
 1.09A 5itzB-5la0A:
undetectable		 5itzB-5la0A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TYR A 197
ARG A 198
THR A 202
 None
 0.69A 5z84J-5la0A:
undetectable		 5z84J-5la0A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 6 LEU A 308
ALA A  88
LEU A 210
SER A 306
 None
 0.95A 6f88B-5la0A:
undetectable		 6f88B-5la0A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A  75
ARG A 121
THR A 122
LEU A 127
 None
 1.36A 6nknW-5la0A:
undetectable		 6nknW-5la0A:
6.72