SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5la7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EVE_A_E20A2001_1
(ACETYLCHOLINESTERASE)		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 10 TRP A 365
GLY A 370
LEU A 464
PHE A 531
TYR A 529
 None
 1.24A 1eveA-5la7A:
0.2		 1eveA-5la7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 11 LEU A 452
PHE A  43
LEU A 524
LEU A 466
LEU A 522
 None
 1.18A 1mx1B-5la7A:
undetectable		 1mx1B-5la7A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 6 SER A 490
THR A 358
LEU A 406
ASP A 403
 None
 0.99A 1mxdA-5la7A:
5.2		 1mxdA-5la7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 8 SER A 490
THR A 358
LEU A 406
ASP A 403
 None
 1.00A 1mxgA-5la7A:
8.7		 1mxgA-5la7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 7 LEU A 495
GLN A 494
LEU A 409
PHE A 531
 EDO  A 609 ( 4.5A)
None
None
None
 0.98A 1v55C-5la7A:
undetectable
1v55J-5la7A:
undetectable		 1v55C-5la7A:
19.44
1v55J-5la7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 7 ALA A 177
TYR A 174
TYR A  91
TYR A 264
 EDO  A 610 ( 4.0A)
EDO  A 610 (-4.2A)
None
None
 1.09A 2ajvH-5la7A:
undetectable
2ajvL-5la7A:
undetectable		 2ajvH-5la7A:
19.61
2ajvL-5la7A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 12 PHE A 386
LEU A  65
LEU A  72
GLU A 113
ARG A  70
 None
 1.16A 2bxfA-5la7A:
undetectable		 2bxfA-5la7A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 12 ALA A 347
GLY A 351
ASN A 390
ALA A 305
ASP A 357
 None
 0.98A 2c49A-5la7A:
undetectable		 2c49A-5la7A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 8 GLY A 243
GLU A 244
ASN A 238
ILE A 237
 None
None
NAG  A 603 (-1.9A)
None
 0.79A 2dtjA-5la7A:
undetectable
2dtjB-5la7A:
undetectable		 2dtjA-5la7A:
15.78
2dtjB-5la7A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 7 LEU A 495
GLN A 494
LEU A 409
PHE A 531
 EDO  A 609 ( 4.5A)
None
None
None
 1.02A 2dysP-5la7A:
undetectable
2dysW-5la7A:
undetectable		 2dysP-5la7A:
19.44
2dysW-5la7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 7 LEU A 495
GLN A 494
LEU A 409
PHE A 531
 EDO  A 609 ( 4.5A)
None
None
None
 0.99A 2eijC-5la7A:
undetectable
2eijJ-5la7A:
undetectable		 2eijC-5la7A:
19.44
2eijJ-5la7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 7 LEU A 495
GLN A 494
LEU A 409
PHE A 531
 EDO  A 609 ( 4.5A)
None
None
None
 0.93A 2eimC-5la7A:
undetectable
2eimJ-5la7A:
undetectable		 2eimC-5la7A:
19.44
2eimJ-5la7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 7 LEU A 495
GLN A 494
LEU A 409
PHE A 531
 EDO  A 609 ( 4.5A)
None
None
None
 0.98A 2einC-5la7A:
undetectable
2einJ-5la7A:
undetectable		 2einC-5la7A:
19.44
2einJ-5la7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 6 LEU A 495
GLN A 494
LEU A 409
PHE A 531
 EDO  A 609 ( 4.5A)
None
None
None
 1.02A 2einP-5la7A:
undetectable
2einW-5la7A:
undetectable		 2einP-5la7A:
19.44
2einW-5la7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 12 ASP A 357
GLY A 362
LEU A 366
LEU A 355
SER A 356
 None
 1.22A 2nv4B-5la7A:
undetectable		 2nv4B-5la7A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 12 LEU A  41
PHE A  43
SER A 528
LEU A 479
VAL A 475
 None
 1.11A 2po7A-5la7A:
undetectable		 2po7A-5la7A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 10 GLU A 113
ILE A  73
ARG A  70
GLU A 143
ASP A  68
 None
 1.25A 2qeoB-5la7A:
undetectable		 2qeoB-5la7A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5la7 HEPARANASE
(Homo
sapiens) 		3 / 3 ARG A 303
GLY A 349
SER A 228
 None
6S6  A 613 (-3.7A)
None
 0.64A 2xctB-5la7A:
undetectable		 2xctB-5la7A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 5 PHE A  94
PHE A 186
LEU A 207
PHE A 104
 None
 1.38A 3abmC-5la7A:
undetectable
3abmJ-5la7A:
undetectable		 3abmC-5la7A:
19.44
3abmJ-5la7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 5 PHE A  94
PHE A 186
LEU A 207
PHE A 104
 None
 1.35A 3ag3C-5la7A:
undetectable
3ag3J-5la7A:
undetectable		 3ag3C-5la7A:
19.44
3ag3J-5la7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 10 GLY A  95
GLY A  96
THR A  97
ASN A  64
GLU A 221
 None
6S6  A 613 (-3.2A)
6S6  A 613 (-4.1A)
None
None
 1.10A 3fw1A-5la7A:
undetectable		 3fw1A-5la7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 7 LEU A 495
GLN A 494
LEU A 409
PHE A 531
 EDO  A 609 ( 4.5A)
None
None
None
 0.93A 3x2qC-5la7A:
undetectable
3x2qJ-5la7A:
undetectable		 3x2qC-5la7A:
19.44
3x2qJ-5la7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 7 LEU A 495
GLN A 494
LEU A 409
PHE A 531
 EDO  A 609 ( 4.5A)
None
None
None
 0.99A 3x2qP-5la7A:
undetectable
3x2qW-5la7A:
undetectable		 3x2qP-5la7A:
19.44
3x2qW-5la7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 5 GLY A  95
GLY A  96
ASN A  64
GLU A 221
 None
6S6  A 613 (-3.2A)
None
None
 1.10A 4fglC-5la7A:
undetectable		 4fglC-5la7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 7 ASP A 100
LEU A 192
GLN A 248
LEU A 249
 None
NAG  A 601 (-4.9A)
None
None
 1.12A 4ib4A-5la7A:
undetectable		 4ib4A-5la7A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 12 LEU A  92
ALA A 388
LEU A  80
LEU A  83
GLY A  86
 None
 1.13A 4l9qB-5la7A:
undetectable		 4l9qB-5la7A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 12 GLY A  95
GLY A  96
THR A  97
ASN A  64
GLU A 221
 None
6S6  A 613 (-3.2A)
6S6  A 613 (-4.1A)
None
None
 1.17A 4zvmA-5la7A:
undetectable
4zvmB-5la7A:
undetectable		 4zvmA-5la7A:
18.09
4zvmB-5la7A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 8 GLY A 350
GLY A 351
VAL A 384
ASP A 357
 6S6  A 613 (-3.7A)
None
None
None
 0.78A 5f8yA-5la7A:
undetectable		 5f8yA-5la7A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 8 GLY A 350
GLY A 351
VAL A 384
HIS A 392
 6S6  A 613 (-3.7A)
None
None
None
 0.73A 5f8yA-5la7A:
undetectable		 5f8yA-5la7A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 8 GLY A 350
GLY A 351
VAL A 384
ASP A 357
 6S6  A 613 (-3.7A)
None
None
None
 0.76A 5f8yB-5la7A:
undetectable		 5f8yB-5la7A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 8 GLY A 350
GLY A 351
VAL A 384
HIS A 392
 6S6  A 613 (-3.7A)
None
None
None
 0.69A 5f8yB-5la7A:
undetectable		 5f8yB-5la7A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 12 LEU A 464
SER A 528
LEU A 452
THR A 451
ARG A 535
 None
 1.37A 5hnxB-5la7A:
undetectable		 5hnxB-5la7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 12 PHE A 363
LEU A 311
ALA A 360
LEU A 479
LEU A 524
 None
 1.12A 5ljeA-5la7A:
undetectable		 5ljeA-5la7A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 12 GLU A 343
GLY A  95
VAL A 326
LEU A 279
GLY A 269
 6S6  A 613 (-1.9A)
None
None
None
None
 1.18A 5vooA-5la7A:
2.9		 5vooA-5la7A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 12 GLU A 343
GLY A  95
VAL A 326
LEU A 279
GLY A 269
 6S6  A 613 (-1.9A)
None
None
None
None
 1.17A 5vooC-5la7A:
2.9		 5vooC-5la7A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 5 PHE A  94
PHE A 186
LEU A 207
PHE A 104
 None
 1.33A 5wauC-5la7A:
undetectable
5wauJ-5la7A:
undetectable		 5wauC-5la7A:
19.44
5wauJ-5la7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 5 PHE A  94
PHE A 186
LEU A 207
PHE A 104
 None
 1.33A 5wauc-5la7A:
undetectable
5wauj-5la7A:
undetectable		 5wauc-5la7A:
19.44
5wauj-5la7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 5 PHE A  94
PHE A 186
LEU A 207
PHE A 104
 None
 1.34A 5xdqP-5la7A:
undetectable
5xdqW-5la7A:
undetectable		 5xdqP-5la7A:
19.44
5xdqW-5la7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5la7 HEPARANASE
(Homo
sapiens) 		5 / 12 GLU A 154
GLU A 343
GLU A 225
HIS A 296
GLY A 223
 EDO  A 612 ( 4.5A)
6S6  A 613 (-1.9A)
6S6  A 613 (-3.4A)
None
None
 1.13A 5xipC-5la7A:
undetectable		 5xipC-5la7A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 7 LEU A 495
GLN A 494
LEU A 409
PHE A 531
 EDO  A 609 ( 4.5A)
None
None
None
 0.94A 5zcoC-5la7A:
undetectable
5zcoJ-5la7A:
undetectable		 5zcoC-5la7A:
19.44
5zcoJ-5la7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 5 GLY A 223
ASN A 224
ASP A 267
ARG A  93
 None
6S6  A 613 (-2.9A)
None
6S6  A 613 ( 4.9A)
 1.30A 6dwdB-5la7A:
undetectable
6dwdD-5la7A:
undetectable		 6dwdB-5la7A:
19.73
6dwdD-5la7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5la7 HEPARANASE
(Homo
sapiens) 		4 / 5 ARG A  93
GLY A 223
ASN A 224
ASP A 267
 6S6  A 613 ( 4.9A)
None
6S6  A 613 (-2.9A)
None
 1.35A 6dwjB-5la7A:
undetectable
6dwjD-5la7A:
undetectable		 6dwjB-5la7A:
19.73
6dwjD-5la7A:
19.73