SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lac'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 5lac 3CL PROTEASE
(Alphamesonivirus
1) 		4 / 5 HIS A 144
LEU A 120
LEU A 203
GLY A 154
 None
 1.14A 1a4lB-5lacA:
undetectable		 1a4lB-5lacA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 5lac 3CL PROTEASE
(Alphamesonivirus
1) 		4 / 5 GLU A 236
THR A 242
LEU A 238
LEU A 241
 None
 1.22A 1u18B-5lacA:
undetectable		 1u18B-5lacA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 5lac 3CL PROTEASE
(Alphamesonivirus
1) 		5 / 12 PHE A  50
ILE A  45
ILE A  43
ILE A  80
TYR A  61
 None
 1.40A 2efjA-5lacA:
undetectable		 2efjA-5lacA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 5lac 3CL PROTEASE
(Alphamesonivirus
1) 		4 / 7 TYR A 275
PHE A 278
PHE A 295
ILE A 187
 None
 1.15A 2zseA-5lacA:
undetectable		 2zseA-5lacA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5lac 3CL PROTEASE
(Alphamesonivirus
1) 		5 / 12 MET A 156
THR A 117
VAL A 116
VAL A  39
ILE A 103
 None
 1.41A 3elzA-5lacA:
undetectable		 3elzA-5lacA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5lac 3CL PROTEASE
(Alphamesonivirus
1) 		5 / 11 MET A 156
THR A 117
VAL A 116
VAL A  39
ILE A 103
 None
 1.32A 3elzB-5lacA:
undetectable		 3elzB-5lacA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5lac 3CL PROTEASE
(Alphamesonivirus
1) 		5 / 12 MET A 156
THR A 117
VAL A 116
VAL A  39
ILE A 103
 None
 1.25A 3em0A-5lacA:
undetectable		 3em0A-5lacA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 5lac 3CL PROTEASE
(Alphamesonivirus
1) 		5 / 12 GLY A 155
GLY A 154
LEU A 132
MET A  15
ILE A  45
 None
 1.26A 3h52B-5lacA:
undetectable		 3h52B-5lacA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5lac 3CL PROTEASE
(Alphamesonivirus
1) 		5 / 12 GLY A 154
VAL A  38
PRO A  21
GLY A 166
LEU A  89
 None
 1.04A 3ku1H-5lacA:
undetectable		 3ku1H-5lacA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5lac 3CL PROTEASE
(Alphamesonivirus
1) 		5 / 12 GLY A  66
GLY A  64
ILE A  80
ILE A  90
PHE A  57
 None
 1.28A 4fglA-5lacA:
undetectable
4fglB-5lacA:
undetectable		 4fglA-5lacA:
19.94
4fglB-5lacA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 5lac 3CL PROTEASE
(Alphamesonivirus
1) 		4 / 8 GLY A 114
ASN A 230
PRO A 160
ILE A   8
 None
 0.92A 4j4vC-5lacA:
undetectable		 4j4vC-5lacA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 5lac 3CL PROTEASE
(Alphamesonivirus
1) 		4 / 5 TYR A  44
ILE A  45
ASN A 205
ILE A  90
 None
 0.97A 4jtpA-5lacA:
undetectable		 4jtpA-5lacA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5lac 3CL PROTEASE
(Alphamesonivirus
1) 		5 / 11 ILE A  90
ALA A  83
LEU A  85
CYH A  70
LEU A  73
 None
 1.16A 4nqaA-5lacA:
undetectable		 4nqaA-5lacA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5lac 3CL PROTEASE
(Alphamesonivirus
1) 		5 / 12 ILE A  90
ALA A  83
LEU A  85
CYH A  70
LEU A  73
 None
 1.16A 4nqaH-5lacA:
undetectable		 4nqaH-5lacA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5lac 3CL PROTEASE
(Alphamesonivirus
1) 		4 / 5 MET A  15
TYR A 119
GLY A 155
GLY A 154
 None
 1.08A 5x7pA-5lacA:
undetectable		 5x7pA-5lacA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 5lac 3CL PROTEASE
(Alphamesonivirus
1) 		4 / 5 LEU A  85
LEU A  67
PRO A  21
ARG A  35
 None
 0.90A 6ew0F-5lacA:
undetectable		 6ew0F-5lacA:
12.78