SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lad'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A 178
ALA A 214
LEU A 215
ILE A 204
ILE A 244
 None
 1.01A 1crbA-5ladA:
undetectable		 1crbA-5ladA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 ASP A 310
LYS A 315
ARG A 318
 None
 1.18A 1ra8A-5ladA:
undetectable		 1ra8A-5ladA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 1.02A 1t85A-5ladA:
undetectable		 1t85A-5ladA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 1.06A 1t87A-5ladA:
undetectable		 1t87A-5ladA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 0.96A 1uyuB-5ladA:
undetectable		 1uyuB-5ladA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 1.00A 1yrcA-5ladA:
undetectable		 1yrcA-5ladA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 1.00A 1yrdA-5ladA:
undetectable		 1yrdA-5ladA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 6 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 0.97A 2feuA-5ladA:
undetectable		 2feuA-5ladA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 1.01A 2feuB-5ladA:
undetectable		 2feuB-5ladA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 HIS A 352
MET A 377
MET A 299
 None
 1.21A 2vj1A-5ladA:
undetectable		 2vj1A-5ladA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 HIS A 352
MET A 377
MET A 363
 None
 1.11A 2vj1A-5ladA:
undetectable		 2vj1A-5ladA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 ILE A 168
LEU A 169
VAL A  57
GLY A 162
 None
 0.72A 2wd9A-5ladA:
5.0		 2wd9A-5ladA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 ILE A 168
LEU A 169
VAL A  57
GLY A 162
 None
 0.74A 2wd9B-5ladA:
4.3		 2wd9B-5ladA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 6 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 1.01A 2zuiA-5ladA:
undetectable		 2zuiA-5ladA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 0.99A 2zwtA-5ladA:
undetectable		 2zwtA-5ladA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 1.00A 2zwuA-5ladA:
undetectable		 2zwuA-5ladA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 0.99A 3fwfA-5ladA:
undetectable		 3fwfA-5ladA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 1.00A 3fwfB-5ladA:
undetectable		 3fwfB-5ladA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 1.03A 3fwiA-5ladA:
undetectable		 3fwiA-5ladA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 1.00A 3fwjA-5ladA:
undetectable		 3fwjA-5ladA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 10 ILE A 168
THR A 164
VAL A 119
ILE A  93
ILE A  12
 None
 1.33A 3kpbD-5ladA:
undetectable		 3kpbD-5ladA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 0.98A 3l63A-5ladA:
undetectable		 3l63A-5ladA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 PHE A 111
VAL A  13
ILE A  12
ILE A 161
 None
 0.91A 3uqbA-5ladA:
undetectable		 3uqbA-5ladA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 1.01A 3wrhA-5ladA:
undetectable		 3wrhA-5ladA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 1.02A 3wrjA-5ladA:
undetectable		 3wrjA-5ladA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 0.99A 3wrlA-5ladA:
undetectable		 3wrlA-5ladA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 1.01A 3wrlE-5ladA:
undetectable		 3wrlE-5ladA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 0.99A 3wrmA-5ladA:
undetectable		 3wrmA-5ladA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 0.98A 3wrmF-5ladA:
undetectable		 3wrmF-5ladA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 LEU A  62
SER A  51
ASP A  90
TYR A  11
 None
 1.07A 4drjB-5ladA:
undetectable		 4drjB-5ladA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 139
THR A  96
LEU A  94
VAL A 108
 None
 1.05A 4l4gA-5ladA:
undetectable		 4l4gA-5ladA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 11 LEU A 387
TYR A 386
HIS A 323
ILE A 316
LEU A 290
 None
 1.48A 4yvpA-5ladA:
undetectable		 4yvpA-5ladA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 ILE A 244
MET A 238
ASP A 183
 None
 0.79A 5h2uA-5ladA:
undetectable		 5h2uA-5ladA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 LEU A 290
ILE A 384
THR A 383
TRP A 319
 None
 1.22A 5ljcA-5ladA:
undetectable		 5ljcA-5ladA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 LEU A 328
ILE A 384
THR A 383
TRP A 319
 None
 1.20A 5ljcA-5ladA:
undetectable		 5ljcA-5ladA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 MET A 369
ASP A 337
ARG A  10
 None
 1.05A 5z6jA-5ladA:
undetectable		 5z6jA-5ladA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5lad PUTATIVE GTP-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 MET A 369
ASP A 337
ARG A  10
 None
 1.05A 5z6kA-5ladA:
undetectable		 5z6kA-5ladA:
17.44