SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lal'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5lal DIRIGENT PROTEIN 6
(Arabidopsis
thaliana) 		5 / 11 MET A 179
ALA A 162
LEU A 183
LEU A 131
PHE A  45
 None
None
None
None
GLY  A 216 ( 4.9A)
 1.15A 3jw5A-5lalA:
undetectable		 3jw5A-5lalA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5lal DIRIGENT PROTEIN 6
(Arabidopsis
thaliana) 		5 / 12 LEU A 120
THR A 119
GLY A 129
ALA A 158
LEU A 183
 None
None
None
EDO  A 211 (-3.9A)
None
 1.16A 3p5nA-5lalA:
undetectable		 3p5nA-5lalA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5lal DIRIGENT PROTEIN 6
(Arabidopsis
thaliana) 		5 / 12 LEU A 120
THR A 119
GLY A 129
ALA A 158
LEU A 183
 None
None
None
EDO  A 211 (-3.9A)
None
 1.15A 3p5nB-5lalA:
undetectable		 3p5nB-5lalA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 5lal DIRIGENT PROTEIN 6
(Arabidopsis
thaliana) 		4 / 6 ILE A 133
LEU A 120
LYS A 178
PHE A  45
 None
None
EDO  A 210 ( 4.7A)
GLY  A 216 ( 4.9A)
 1.03A 3sj1X-5lalA:
undetectable		 3sj1X-5lalA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 5lal DIRIGENT PROTEIN 6
(Arabidopsis
thaliana) 		4 / 9 PHE A 155
HIS A 127
PHE A  45
ILE A 133
 None
GLY  A 216 ( 3.6A)
GLY  A 216 ( 4.9A)
None
 1.34A 4jvlA-5lalA:
undetectable		 4jvlA-5lalA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 5lal DIRIGENT PROTEIN 6
(Arabidopsis
thaliana) 		3 / 3 LYS A 178
ARG A 176
HIS A  48
 EDO  A 210 ( 4.7A)
None
None
 1.04A 4zbrA-5lalA:
undetectable		 4zbrA-5lalA:
13.40