SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lb8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		3 / 3 ALA A 286
VAL A 310
TRP A 305
 None
 0.97A 1av2A-5lb8A:
undetectable
1av2B-5lb8A:
undetectable		 1av2A-5lb8A:
4.12
1av2B-5lb8A:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		5 / 12 LEU A  93
GLY A  55
ALA A  56
SER A  59
LEU A  60
 None
 0.85A 1cqeA-5lb8A:
undetectable		 1cqeA-5lb8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		5 / 12 LEU A  93
GLY A  55
ALA A  56
SER A  59
LEU A  60
 None
 0.86A 1cqeB-5lb8A:
undetectable		 1cqeB-5lb8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		5 / 12 LEU A  93
GLY A  55
ALA A  56
SER A  59
LEU A  60
 None
 0.76A 1eqhA-5lb8A:
undetectable		 1eqhA-5lb8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		5 / 12 LEU A  93
GLY A  55
ALA A  56
SER A  59
LEU A  60
 None
 0.80A 1eqhB-5lb8A:
undetectable		 1eqhB-5lb8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2R_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.35A 1k2rA-5lb8A:
undetectable
1k2rB-5lb8A:
undetectable		 1k2rA-5lb8A:
20.27
1k2rB-5lb8A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2R_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.35A 1k2rA-5lb8A:
undetectable
1k2rB-5lb8A:
undetectable		 1k2rA-5lb8A:
20.27
1k2rB-5lb8A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.36A 1lzxA-5lb8A:
undetectable
1lzxB-5lb8A:
undetectable		 1lzxA-5lb8A:
20.27
1lzxB-5lb8A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZZ_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.40A 1lzzA-5lb8A:
undetectable
1lzzB-5lb8A:
undetectable		 1lzzA-5lb8A:
20.27
1lzzB-5lb8A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMW_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.38A 1mmwA-5lb8A:
undetectable
1mmwB-5lb8A:
undetectable		 1mmwA-5lb8A:
20.27
1mmwB-5lb8A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM4_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.38A 1om4A-5lb8A:
undetectable
1om4B-5lb8A:
undetectable		 1om4A-5lb8A:
20.19
1om4B-5lb8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6I_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.40A 1p6iA-5lb8A:
undetectable
1p6iB-5lb8A:
undetectable		 1p6iA-5lb8A:
20.27
1p6iB-5lb8A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 8 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.29A 1rs6A-5lb8A:
undetectable
1rs6B-5lb8A:
undetectable		 1rs6A-5lb8A:
20.27
1rs6B-5lb8A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		3 / 3 ALA A 286
VAL A 310
TRP A 305
 None
 0.93A 1w5uA-5lb8A:
undetectable
1w5uB-5lb8A:
undetectable		 1w5uA-5lb8A:
4.12
1w5uB-5lb8A:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 8 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.39A 2g6hA-5lb8A:
undetectable
2g6hB-5lb8A:
undetectable		 2g6hA-5lb8A:
20.19
2g6hB-5lb8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6K_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.40A 2g6kA-5lb8A:
undetectable
2g6kB-5lb8A:
undetectable		 2g6kA-5lb8A:
20.19
2g6kB-5lb8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 6 ARG A 175
THR A 129
ALA A 133
PRO A  78
 None
 1.42A 2ql8A-5lb8A:
undetectable
2ql8B-5lb8A:
undetectable		 2ql8A-5lb8A:
14.68
2ql8B-5lb8A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 5 VAL A 162
TYR A 173
VAL A 156
ASP A 157
 None
 1.33A 2x45C-5lb8A:
undetectable		 2x45C-5lb8A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_B_C2FB401_0
(AMINOMETHYLTRANSFERA
SE)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		5 / 12 ILE A 263
TYR A 265
VAL A 331
PHE A 319
MET A 306
 None
 1.02A 3a8iB-5lb8A:
undetectable		 3a8iB-5lb8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_C_C2FC401_0
(AMINOMETHYLTRANSFERA
SE)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		5 / 12 ILE A 263
TYR A 265
VAL A 331
PHE A 319
MET A 306
 None
 1.06A 3a8iC-5lb8A:
undetectable		 3a8iC-5lb8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		5 / 12 ILE A 263
TYR A 265
VAL A 331
PHE A 319
MET A 306
 None
 1.03A 3a8iD-5lb8A:
undetectable		 3a8iD-5lb8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.42A 3b3mA-5lb8A:
undetectable
3b3mB-5lb8A:
undetectable		 3b3mA-5lb8A:
20.19
3b3mB-5lb8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 8 VAL A  41
VAL A  42
GLY A  44
PRO A 187
 None
 0.94A 3bjwA-5lb8A:
undetectable		 3bjwA-5lb8A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		5 / 10 LEU A 179
LEU A 151
ILE A 128
LEU A 126
PHE A 138
 None
 1.04A 3jw5B-5lb8A:
undetectable		 3jw5B-5lb8A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		5 / 12 GLY A 166
ILE A 336
GLY A 342
ALA A 341
ALA A 401
 None
 1.02A 3sudB-5lb8A:
undetectable		 3sudB-5lb8A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		3 / 3 PHE A 221
CYH A 427
HIS A 413
 None
ZN  A 601 ( 4.2A)
None
 1.20A 3u9fF-5lb8A:
undetectable		 3u9fF-5lb8A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		3 / 3 PHE A 221
CYH A 427
HIS A 413
 None
ZN  A 601 ( 4.2A)
None
 1.24A 3u9fG-5lb8A:
undetectable		 3u9fG-5lb8A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		3 / 3 PHE A 221
CYH A 427
HIS A 413
 None
ZN  A 601 ( 4.2A)
None
 1.14A 3u9fL-5lb8A:
undetectable		 3u9fL-5lb8A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		3 / 3 LYS A  22
ARG A  96
LEU A  67
 None
 1.27A 3v4tE-5lb8A:
1.4		 3v4tE-5lb8A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		5 / 11 ASN A 285
GLY A 283
SER A 280
PRO A 311
GLY A 262
 None
 1.32A 4a6nC-5lb8A:
undetectable		 4a6nC-5lb8A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_C_H4BC760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.33A 4d1nC-5lb8A:
undetectable
4d1nD-5lb8A:
undetectable		 4d1nC-5lb8A:
19.29
4d1nD-5lb8A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCH_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.44A 4kchA-5lb8A:
undetectable
4kchB-5lb8A:
undetectable		 4kchA-5lb8A:
20.19
4kchB-5lb8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		5 / 10 LEU A  93
GLY A  55
ALA A  56
SER A  59
LEU A  60
 None
 0.88A 4ph9A-5lb8A:
undetectable		 4ph9A-5lb8A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		5 / 10 LEU A  93
GLY A  55
ALA A  56
SER A  59
LEU A  60
 None
 0.91A 4ph9B-5lb8A:
undetectable		 4ph9B-5lb8A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		5 / 7 ALA A 401
SER A 347
GLY A 342
ALA A 341
THR A 194
 None
 1.38A 4r1zB-5lb8A:
undetectable		 4r1zB-5lb8A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH1_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.39A 4uh1A-5lb8A:
undetectable
4uh1B-5lb8A:
undetectable		 4uh1A-5lb8A:
20.19
4uh1B-5lb8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 6 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.31A 4v3wA-5lb8A:
undetectable
4v3wB-5lb8A:
undetectable		 4v3wA-5lb8A:
20.19
4v3wB-5lb8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3X_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.41A 4v3xA-5lb8A:
undetectable
4v3xB-5lb8A:
undetectable		 4v3xA-5lb8A:
20.19
4v3xB-5lb8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.29A 5ad5A-5lb8A:
undetectable
5ad5B-5lb8A:
undetectable		 5ad5A-5lb8A:
20.19
5ad5B-5lb8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.32A 5fvtA-5lb8A:
undetectable
5fvtB-5lb8A:
undetectable		 5fvtA-5lb8A:
20.19
5fvtB-5lb8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.24A 5fvtA-5lb8A:
undetectable
5fvtB-5lb8A:
undetectable		 5fvtA-5lb8A:
20.19
5fvtB-5lb8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.30A 5fvvA-5lb8A:
undetectable
5fvvB-5lb8A:
undetectable		 5fvvA-5lb8A:
19.88
5fvvB-5lb8A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.33A 5fvvA-5lb8A:
undetectable
5fvvB-5lb8A:
undetectable		 5fvvA-5lb8A:
19.88
5fvvB-5lb8A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.25A 5fvwA-5lb8A:
undetectable
5fvwB-5lb8A:
undetectable		 5fvwA-5lb8A:
19.88
5fvwB-5lb8A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.24A 5fvxA-5lb8A:
undetectable
5fvxB-5lb8A:
undetectable		 5fvxA-5lb8A:
19.88
5fvxB-5lb8A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.29A 5g0nA-5lb8A:
undetectable
5g0nB-5lb8A:
undetectable		 5g0nA-5lb8A:
19.81
5g0nB-5lb8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.26A 5g0nA-5lb8A:
undetectable
5g0nB-5lb8A:
undetectable		 5g0nA-5lb8A:
19.81
5g0nB-5lb8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		5 / 12 LEU A  93
GLY A  55
ALA A  56
SER A  59
LEU A  60
 None
 0.78A 5jvzA-5lb8A:
undetectable		 5jvzA-5lb8A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		5 / 12 LEU A  93
GLY A  55
ALA A  56
SER A  59
LEU A  60
 None
 0.83A 5jvzB-5lb8A:
undetectable		 5jvzB-5lb8A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		3 / 3 SER A 339
ALA A 341
THR A 194
 None
 0.70A 5n0xB-5lb8A:
undetectable		 5n0xB-5lb8A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.27A 5untA-5lb8A:
undetectable
5untB-5lb8A:
undetectable		 5untA-5lb8A:
20.19
5untB-5lb8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.25A 5vuiA-5lb8A:
undetectable
5vuiB-5lb8A:
undetectable		 5vuiA-5lb8A:
20.19
5vuiB-5lb8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.26A 6aurA-5lb8A:
undetectable
6aurB-5lb8A:
undetectable		 6aurA-5lb8A:
9.98
6aurB-5lb8A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.26A 6aurA-5lb8A:
undetectable
6aurB-5lb8A:
undetectable		 6aurA-5lb8A:
9.98
6aurB-5lb8A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.31A 6auyA-5lb8A:
undetectable
6auyB-5lb8A:
undetectable		 6auyA-5lb8A:
10.59
6auyB-5lb8A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.27A 6av3A-5lb8A:
undetectable
6av3B-5lb8A:
undetectable		 6av3A-5lb8A:
10.59
6av3B-5lb8A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.28A 6av4A-5lb8A:
undetectable
6av4B-5lb8A:
undetectable		 6av4A-5lb8A:
10.59
6av4B-5lb8A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.29A 6av5A-5lb8A:
undetectable
6av5B-5lb8A:
undetectable		 6av5A-5lb8A:
10.59
6av5B-5lb8A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.26A 6av5A-5lb8A:
undetectable
6av5B-5lb8A:
undetectable		 6av5A-5lb8A:
10.59
6av5B-5lb8A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.27A 6cicA-5lb8A:
undetectable
6cicB-5lb8A:
undetectable		 6cicA-5lb8A:
10.59
6cicB-5lb8A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_B_H4BB802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.27A 6cicA-5lb8A:
undetectable
6cicB-5lb8A:
undetectable		 6cicA-5lb8A:
10.59
6cicB-5lb8A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 MET A 306
VAL A 310
TRP A 305
GLU A 307
 None
 1.25A 6cidA-5lb8A:
undetectable
6cidB-5lb8A:
undetectable		 6cidA-5lb8A:
10.59
6cidB-5lb8A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_B_H4BB803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 7 GLU A 307
MET A 306
VAL A 310
TRP A 305
 None
 1.26A 6cidA-5lb8A:
undetectable
6cidB-5lb8A:
undetectable		 6cidA-5lb8A:
10.59
6cidB-5lb8A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		4 / 4 HIS A 290
VAL A 301
LEU A 293
ALA A 288
 None
 0.82A 6d8pB-5lb8A:
2.4		 6d8pB-5lb8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens) 		5 / 12 ASP A  85
ASP A 353
ALA A  56
SER A  59
LEU A  93
 None
 1.08A 6ew0F-5lb8A:
undetectable		 6ew0F-5lb8A:
9.78