SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5lc2 PROTEIN FAM3C
(Homo
sapiens) 		4 / 7 SER A 170
VAL A 106
GLY A 148
ILE A 104
 None
 0.85A 1gtnC-5lc2A:
undetectable
1gtnD-5lc2A:
undetectable		 1gtnC-5lc2A:
18.54
1gtnD-5lc2A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5lc2 PROTEIN FAM3C
(Homo
sapiens) 		3 / 3 ARG A 179
ASP A 123
ASP A 128
 None
 0.77A 2ejtA-5lc2A:
undetectable		 2ejtA-5lc2A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5lc2 PROTEIN FAM3C
(Homo
sapiens) 		4 / 5 ASN A 181
PRO A 213
TYR A 209
ALA A  78
 None
 1.24A 3twpD-5lc2A:
undetectable		 3twpD-5lc2A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5lc2 PROTEIN FAM3C
(Homo
sapiens) 		4 / 8 HIS A  68
PRO A  65
SER A 194
PHE A 196
 None
 1.07A 4kttC-5lc2A:
undetectable		 4kttC-5lc2A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5lc2 PROTEIN FAM3C
(Homo
sapiens) 		4 / 8 HIS A  68
PRO A  65
SER A 194
PHE A 196
 None
 1.13A 4ndnA-5lc2A:
undetectable		 4ndnA-5lc2A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5lc2 PROTEIN FAM3C
(Homo
sapiens) 		4 / 7 HIS A  68
PRO A  65
SER A 194
PHE A 196
 None
 1.08A 4ndnC-5lc2A:
undetectable		 4ndnC-5lc2A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5lc2 PROTEIN FAM3C
(Homo
sapiens) 		4 / 7 HIS A  68
PRO A  65
SER A 194
PHE A 196
 None
 1.11A 4odjA-5lc2A:
undetectable		 4odjA-5lc2A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 5lc2 PROTEIN FAM3C
(Homo
sapiens) 		5 / 11 ILE A 165
THR A 171
SER A 170
GLY A 169
GLU A 197
 None
 1.24A 4xt7A-5lc2A:
undetectable		 4xt7A-5lc2A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5lc2 PROTEIN FAM3C
(Homo
sapiens) 		4 / 8 HIS A  68
PRO A  65
SER A 194
PHE A 196
 None
 1.12A 6fbnB-5lc2A:
undetectable		 6fbnB-5lc2A:
18.09